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Low dietary folate intake is associated with an excess incidence of acute coronary events: The Kuopio Ischemic Heart Disease Risk Factor Study.
Circulation 2001; 103(22):2674-80Circ

Abstract

BACKGROUND

Although several prospective studies have shown that low folate intake and low circulating folate are associated with increased risk of coronary heart disease (CHD), the findings are inconsistent.

METHODS AND RESULTS

We studied the associations of dietary intake of folate, vitamin B(6), and vitamin B(12) with the risk of acute coronary events in a prospective cohort study of 1980 Finnish men 42 to 60 years old examined in 1984 to 1989 in the Kuopio Ischemic Heart Disease Risk Factor Study. Nutrient intakes were assessed by 4-day food record. During an average follow-up time of 10 years, 199 acute coronary events occurred. In a Cox proportional hazards model adjusted for 21 conventional and nutritional CHD risk factors, men in the highest fifth of folate intake had a relative risk of acute coronary events of 0.45 (95% CI 0.25 to 0.81, P=0.008) compared with men in the lowest fifth. This association was stronger in nonsmokers and light alcohol users than in smokers and alcohol users. A high dietary intake of vitamin B(6) had no significant association and that of vitamin B(12) a weak association with a reduced risk of acute coronary events.

CONCLUSIONS

The present work in CHD-free middle-aged men is the first prospective cohort study to observe a significant inverse association between quantitatively assessed moderate-to-high folate intakes and incidence of acute coronary events in men. Our findings provide further support in favor of a role of folate in the promotion of good cardiovascular health.

Authors+Show Affiliations

Research Institute of Public Health, University of Kuopio, Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11390336

Citation

Voutilainen, S, et al. "Low Dietary Folate Intake Is Associated With an Excess Incidence of Acute Coronary Events: the Kuopio Ischemic Heart Disease Risk Factor Study." Circulation, vol. 103, no. 22, 2001, pp. 2674-80.
Voutilainen S, Rissanen TH, Virtanen J, et al. Low dietary folate intake is associated with an excess incidence of acute coronary events: The Kuopio Ischemic Heart Disease Risk Factor Study. Circulation. 2001;103(22):2674-80.
Voutilainen, S., Rissanen, T. H., Virtanen, J., Lakka, T. A., & Salonen, J. T. (2001). Low dietary folate intake is associated with an excess incidence of acute coronary events: The Kuopio Ischemic Heart Disease Risk Factor Study. Circulation, 103(22), pp. 2674-80.
Voutilainen S, et al. Low Dietary Folate Intake Is Associated With an Excess Incidence of Acute Coronary Events: the Kuopio Ischemic Heart Disease Risk Factor Study. Circulation. 2001 Jun 5;103(22):2674-80. PubMed PMID: 11390336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low dietary folate intake is associated with an excess incidence of acute coronary events: The Kuopio Ischemic Heart Disease Risk Factor Study. AU - Voutilainen,S, AU - Rissanen,T H, AU - Virtanen,J, AU - Lakka,T A, AU - Salonen,J T, AU - ,, PY - 2001/6/8/pubmed PY - 2001/7/13/medline PY - 2001/6/8/entrez SP - 2674 EP - 80 JF - Circulation JO - Circulation VL - 103 IS - 22 N2 - BACKGROUND: Although several prospective studies have shown that low folate intake and low circulating folate are associated with increased risk of coronary heart disease (CHD), the findings are inconsistent. METHODS AND RESULTS: We studied the associations of dietary intake of folate, vitamin B(6), and vitamin B(12) with the risk of acute coronary events in a prospective cohort study of 1980 Finnish men 42 to 60 years old examined in 1984 to 1989 in the Kuopio Ischemic Heart Disease Risk Factor Study. Nutrient intakes were assessed by 4-day food record. During an average follow-up time of 10 years, 199 acute coronary events occurred. In a Cox proportional hazards model adjusted for 21 conventional and nutritional CHD risk factors, men in the highest fifth of folate intake had a relative risk of acute coronary events of 0.45 (95% CI 0.25 to 0.81, P=0.008) compared with men in the lowest fifth. This association was stronger in nonsmokers and light alcohol users than in smokers and alcohol users. A high dietary intake of vitamin B(6) had no significant association and that of vitamin B(12) a weak association with a reduced risk of acute coronary events. CONCLUSIONS: The present work in CHD-free middle-aged men is the first prospective cohort study to observe a significant inverse association between quantitatively assessed moderate-to-high folate intakes and incidence of acute coronary events in men. Our findings provide further support in favor of a role of folate in the promotion of good cardiovascular health. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/11390336/full_citation L2 - http://www.ahajournals.org/doi/full/10.1161/01.cir.103.22.2674?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -