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The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics.
J Clin Invest. 2001 Jun; 107(11):1357-64.JCI

Abstract

In vitro polarized human Th2 cells preferentially express the chemokine receptors CCR3, CCR4, and CCR8 and migrate to their ligands: eotaxin, monocyte-derived chemokine (MDC), thymus- and activation-regulated chemokine (TARC), and I-309. We have studied the expression of chemokines and chemokine receptors in the airway mucosa of atopic asthmatics. Immunofluorescent analysis of endobronchial biopsies from six asthmatics, taken 24 hours after allergen challenge, demonstrates that virtually all T cells express IL-4 and CCR4. CCR8 is coexpressed with CCR4 on 28% of the T cells, while CCR3 is expressed on eosinophils but not on T cells. Expression of the CCR4-specific ligands MDC and TARC is strongly upregulated on airway epithelial cells upon allergen challenge, suggesting an involvement of this receptor/ligand axis in the regulation of lymphocyte recruitment into the asthmatic bronchi. In contrast to asthma, T cells infiltrating the airways of patients with chronic obstructive pulmonary disease and pulmonary sarcoidosis produce IFN-gamma and express high levels of CXCR3, while lacking CCR4 and CCR8 expression. These data support the role of CCR4, of its ligands MDC and TARC, and of CCR8 in the pathogenesis of allergen-induced late asthmatic responses and suggest that these molecules could be considered as targets for therapeutic intervention.

Authors+Show Affiliations

Roche Milano Ricerche, Milano, Italy. paola.panina@roche.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11390417

Citation

Panina-Bordignon, P, et al. "The C-C Chemokine Receptors CCR4 and CCR8 Identify Airway T Cells of Allergen-challenged Atopic Asthmatics." The Journal of Clinical Investigation, vol. 107, no. 11, 2001, pp. 1357-64.
Panina-Bordignon P, Papi A, Mariani M, et al. The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J Clin Invest. 2001;107(11):1357-64.
Panina-Bordignon, P., Papi, A., Mariani, M., Di Lucia, P., Casoni, G., Bellettato, C., Buonsanti, C., Miotto, D., Mapp, C., Villa, A., Arrigoni, G., Fabbri, L. M., & Sinigaglia, F. (2001). The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. The Journal of Clinical Investigation, 107(11), 1357-64.
Panina-Bordignon P, et al. The C-C Chemokine Receptors CCR4 and CCR8 Identify Airway T Cells of Allergen-challenged Atopic Asthmatics. J Clin Invest. 2001;107(11):1357-64. PubMed PMID: 11390417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. AU - Panina-Bordignon,P, AU - Papi,A, AU - Mariani,M, AU - Di Lucia,P, AU - Casoni,G, AU - Bellettato,C, AU - Buonsanti,C, AU - Miotto,D, AU - Mapp,C, AU - Villa,A, AU - Arrigoni,G, AU - Fabbri,L M, AU - Sinigaglia,F, PY - 2001/6/8/pubmed PY - 2001/6/29/medline PY - 2001/6/8/entrez SP - 1357 EP - 64 JF - The Journal of clinical investigation JO - J Clin Invest VL - 107 IS - 11 N2 - In vitro polarized human Th2 cells preferentially express the chemokine receptors CCR3, CCR4, and CCR8 and migrate to their ligands: eotaxin, monocyte-derived chemokine (MDC), thymus- and activation-regulated chemokine (TARC), and I-309. We have studied the expression of chemokines and chemokine receptors in the airway mucosa of atopic asthmatics. Immunofluorescent analysis of endobronchial biopsies from six asthmatics, taken 24 hours after allergen challenge, demonstrates that virtually all T cells express IL-4 and CCR4. CCR8 is coexpressed with CCR4 on 28% of the T cells, while CCR3 is expressed on eosinophils but not on T cells. Expression of the CCR4-specific ligands MDC and TARC is strongly upregulated on airway epithelial cells upon allergen challenge, suggesting an involvement of this receptor/ligand axis in the regulation of lymphocyte recruitment into the asthmatic bronchi. In contrast to asthma, T cells infiltrating the airways of patients with chronic obstructive pulmonary disease and pulmonary sarcoidosis produce IFN-gamma and express high levels of CXCR3, while lacking CCR4 and CCR8 expression. These data support the role of CCR4, of its ligands MDC and TARC, and of CCR8 in the pathogenesis of allergen-induced late asthmatic responses and suggest that these molecules could be considered as targets for therapeutic intervention. SN - 0021-9738 UR - https://www.unboundmedicine.com/medline/citation/11390417/The_C_C_chemokine_receptors_CCR4_and_CCR8_identify_airway_T_cells_of_allergen_challenged_atopic_asthmatics_ L2 - https://doi.org/10.1172/JCI12655 DB - PRIME DP - Unbound Medicine ER -