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The accuracy of head and neck carcinoma sentinel lymph node biopsy in the clinically N0 neck.
Cancer. 2001 Jun 01; 91(11):2077-83.C

Abstract

BACKGROUND

Sentinel lymph node (SLN) biopsy originally was described as a means of identifying lymph node metastases in malignant melanoma and breast carcinoma. The use of SLN biopsy in patients with oral and oropharyngeal squamous cell carcinoma and clinically N0 necks was investigated to determine whether the pathology of the SLN reflected that of the neck.

METHODS

Patients undergoing elective neck dissections for head and neck squamous cell carcinoma accessible to injection were enrolled into our study. Sentinel lymph node biopsy was performed after blue dye and radiocolloid injection. Preoperative lymphoscintigraphy and the perioperative use of a gamma probe identified radioactive SLNs; visualization of blue stained lymphatics identified blue SLNs. A neck dissection completed the surgical procedure, and the pathology of the SLN was compared with that of the remaining neck dissection.

RESULTS

Sentinel lymph node biopsy was performed on 40 cases with clinically N0 necks. Twenty were pathologically clear of tumor and 20 contained subclinical metastases. SLNs were found in 17 necks with pathologic disease and contained metastases in 16. The sentinel lymph node was the only lymph node containing tumor in 12 of 16.

CONCLUSIONS

The SLN, in head and neck carcinomas accessible to injection without anesthesia, is an accurate reflector of the status of the regional lymph nodes, when found in patients with early tumors. Sentinel lymph nodes may be found in clinically unpredictable sites, and SLN biopsy may aid in identifying the clinically N0 patient with early lymph node disease. If SLNs cannot be located in the neck, an elective lymph node dissection should be considered.

Authors+Show Affiliations

Plastic Surgery Unit, Canniesburn Hospital, Bearsden, Glasgow, United Kingdom. Hospital and School, Glasgow, United Kingdom. tshoaib@canniesburn.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11391588

Citation

Shoaib, T, et al. "The Accuracy of Head and Neck Carcinoma Sentinel Lymph Node Biopsy in the Clinically N0 Neck." Cancer, vol. 91, no. 11, 2001, pp. 2077-83.
Shoaib T, Soutar DS, MacDonald DG, et al. The accuracy of head and neck carcinoma sentinel lymph node biopsy in the clinically N0 neck. Cancer. 2001;91(11):2077-83.
Shoaib, T., Soutar, D. S., MacDonald, D. G., Camilleri, I. G., Dunaway, D. J., Gray, H. W., McCurrach, G. M., Bessent, R. G., MacLeod, T. I., & Robertson, A. G. (2001). The accuracy of head and neck carcinoma sentinel lymph node biopsy in the clinically N0 neck. Cancer, 91(11), 2077-83.
Shoaib T, et al. The Accuracy of Head and Neck Carcinoma Sentinel Lymph Node Biopsy in the Clinically N0 Neck. Cancer. 2001 Jun 1;91(11):2077-83. PubMed PMID: 11391588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The accuracy of head and neck carcinoma sentinel lymph node biopsy in the clinically N0 neck. AU - Shoaib,T, AU - Soutar,D S, AU - MacDonald,D G, AU - Camilleri,I G, AU - Dunaway,D J, AU - Gray,H W, AU - McCurrach,G M, AU - Bessent,R G, AU - MacLeod,T I, AU - Robertson,A G, PY - 2001/6/8/pubmed PY - 2001/6/29/medline PY - 2001/6/8/entrez SP - 2077 EP - 83 JF - Cancer JO - Cancer VL - 91 IS - 11 N2 - BACKGROUND: Sentinel lymph node (SLN) biopsy originally was described as a means of identifying lymph node metastases in malignant melanoma and breast carcinoma. The use of SLN biopsy in patients with oral and oropharyngeal squamous cell carcinoma and clinically N0 necks was investigated to determine whether the pathology of the SLN reflected that of the neck. METHODS: Patients undergoing elective neck dissections for head and neck squamous cell carcinoma accessible to injection were enrolled into our study. Sentinel lymph node biopsy was performed after blue dye and radiocolloid injection. Preoperative lymphoscintigraphy and the perioperative use of a gamma probe identified radioactive SLNs; visualization of blue stained lymphatics identified blue SLNs. A neck dissection completed the surgical procedure, and the pathology of the SLN was compared with that of the remaining neck dissection. RESULTS: Sentinel lymph node biopsy was performed on 40 cases with clinically N0 necks. Twenty were pathologically clear of tumor and 20 contained subclinical metastases. SLNs were found in 17 necks with pathologic disease and contained metastases in 16. The sentinel lymph node was the only lymph node containing tumor in 12 of 16. CONCLUSIONS: The SLN, in head and neck carcinomas accessible to injection without anesthesia, is an accurate reflector of the status of the regional lymph nodes, when found in patients with early tumors. Sentinel lymph nodes may be found in clinically unpredictable sites, and SLN biopsy may aid in identifying the clinically N0 patient with early lymph node disease. If SLNs cannot be located in the neck, an elective lymph node dissection should be considered. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/11391588/The_accuracy_of_head_and_neck_carcinoma_sentinel_lymph_node_biopsy_in_the_clinically_N0_neck_ L2 - https://medlineplus.gov/oralcancer.html DB - PRIME DP - Unbound Medicine ER -