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Treatment of malaria in north-eastern and south-eastern Nigeria: a population study of mefloquine, sulphadoxine, pyrimethamine combination (MSP) vs chloroquine (CQ).
West Afr J Med. 2000 Oct-Dec; 19(4):293-7.WA

Abstract

In a population-based study involving 4019 patients in 20 peripheral health facilities in Nigeria, the outcome of presumptive malaria treatment with MSP was compared to that of CQ. The study was conducted between January 1995 and January 1996. Patients aged 6 months or more with a clinical diagnosis of malaria based on history of fever and axillary temperature > 37.5 degrees C were either treated with MSP (250 mg mefloquine, 500 mg sulphadoxine, and 25 mg pyrimethamine per tablet) or CQ (150 mg chloroquine base per tablet). The clinical cure rate was assessed by the disappearance of clinical signs and symptoms over a 7-day period. Tolerability was assessed by the incidence of adverse events (adverse drug reaction and intercurrent illness). The result shows that the clinical care rate of suspected malaria was 97.6% with MSP and 85.6% with CQ. The incidence of adverse event was 9.5% with MSP and 9.2% with CQ. The withdrawal rate was 2.0% with MSP and 5.0% with CQ; 3.5% of the patients in the CQ group withdrew due to adverse events compared to 0.47% with MSP. In conclusion it was observed that in addition to superior efficacy of MSP over CQ, fever clearance rate with MSP was comparable to that of CQ. The study also demonstrated that two tablets maximum dose of MSP is safe and effective in a large population of Nigeria malaria patients.

Authors+Show Affiliations

Consultant Malarialogist, Lanex International Agency, Lagos, Nigeria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11391844

Citation

Ekanem, O J., et al. "Treatment of Malaria in North-eastern and South-eastern Nigeria: a Population Study of Mefloquine, Sulphadoxine, Pyrimethamine Combination (MSP) Vs Chloroquine (CQ)." West African Journal of Medicine, vol. 19, no. 4, 2000, pp. 293-7.
Ekanem OJ, Ezedinachi EN, Molta NB, et al. Treatment of malaria in north-eastern and south-eastern Nigeria: a population study of mefloquine, sulphadoxine, pyrimethamine combination (MSP) vs chloroquine (CQ). West Afr J Med. 2000;19(4):293-7.
Ekanem, O. J., Ezedinachi, E. N., Molta, N. B., Watila, I. M., Chukwuani, C. M., Meremikwu, M. M., Akpede, G., & Ojar, E. A. (2000). Treatment of malaria in north-eastern and south-eastern Nigeria: a population study of mefloquine, sulphadoxine, pyrimethamine combination (MSP) vs chloroquine (CQ). West African Journal of Medicine, 19(4), 293-7.
Ekanem OJ, et al. Treatment of Malaria in North-eastern and South-eastern Nigeria: a Population Study of Mefloquine, Sulphadoxine, Pyrimethamine Combination (MSP) Vs Chloroquine (CQ). West Afr J Med. 2000 Oct-Dec;19(4):293-7. PubMed PMID: 11391844.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of malaria in north-eastern and south-eastern Nigeria: a population study of mefloquine, sulphadoxine, pyrimethamine combination (MSP) vs chloroquine (CQ). AU - Ekanem,O J, AU - Ezedinachi,E N, AU - Molta,N B, AU - Watila,I M, AU - Chukwuani,C M, AU - Meremikwu,M M, AU - Akpede,G, AU - Ojar,E A, PY - 2001/6/8/pubmed PY - 2001/6/29/medline PY - 2001/6/8/entrez SP - 293 EP - 7 JF - West African journal of medicine JO - West Afr J Med VL - 19 IS - 4 N2 - In a population-based study involving 4019 patients in 20 peripheral health facilities in Nigeria, the outcome of presumptive malaria treatment with MSP was compared to that of CQ. The study was conducted between January 1995 and January 1996. Patients aged 6 months or more with a clinical diagnosis of malaria based on history of fever and axillary temperature > 37.5 degrees C were either treated with MSP (250 mg mefloquine, 500 mg sulphadoxine, and 25 mg pyrimethamine per tablet) or CQ (150 mg chloroquine base per tablet). The clinical cure rate was assessed by the disappearance of clinical signs and symptoms over a 7-day period. Tolerability was assessed by the incidence of adverse events (adverse drug reaction and intercurrent illness). The result shows that the clinical care rate of suspected malaria was 97.6% with MSP and 85.6% with CQ. The incidence of adverse event was 9.5% with MSP and 9.2% with CQ. The withdrawal rate was 2.0% with MSP and 5.0% with CQ; 3.5% of the patients in the CQ group withdrew due to adverse events compared to 0.47% with MSP. In conclusion it was observed that in addition to superior efficacy of MSP over CQ, fever clearance rate with MSP was comparable to that of CQ. The study also demonstrated that two tablets maximum dose of MSP is safe and effective in a large population of Nigeria malaria patients. SN - 0189-160X UR - https://www.unboundmedicine.com/medline/citation/11391844/Treatment_of_malaria_in_north_eastern_and_south_eastern_Nigeria:_a_population_study_of_mefloquine_sulphadoxine_pyrimethamine_combination__MSP__vs_chloroquine__CQ__ L2 - https://www.diseaseinfosearch.org/result/4415 DB - PRIME DP - Unbound Medicine ER -