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Effects of unkei-to, an herbal medicine, on endocrine function and ovulation in women with high basal levels of luteinizing hormone secretion.
J Reprod Med. 2001 May; 46(5):451-6.JR

Abstract

OBJECTIVE

To treat anovulatory women with high plasma LH levels with unkei-to.

STUDY DESIGN

A total of 100 patients with polycystic ovary syndrome (n = 38) or non-polycystic ovary syndrome (n = 62) were allocated randomly into two groups. Endocrine levels (FSH, LH and estradiol), follicle growth and response to unkei-to were compared for 52 subjects in the unkei-to group and 48 subjects in the control group.

RESULTS

Unkei-to induced significant decreases in plasma LH in polycystic ovary syndrome and non-polycystic ovary syndrome with high LH levels. Plasma estradiol levels increased significantly (43.5%) in eight weeks of treatment with unkei-to. Significant development of the dominant follicle was also observed in patients treated with unkei-to. When women suffering from ovulatory failure or irregular menstruation and having high plasma LH concentration were treated with unkei-to for eight weeks, a reduction in the serum LH level of at least 1 SD from baseline was noted in 45.5% of polycystic ovary syndrome patients and in 80.0% of non-polycystic ovary syndrome patients. The mean rate of reduction of serum LH was 22.2 +/- 35.7% in polycystic ovary syndrome patients and 49.7 +/- 15.3% in non-polycystic ovary syndrome patients. This reduction was significant in the non-polycystic ovary syndrome patients (P = .030). The rate of menstrual cycle improvement, including successful ovulation, was 50.0% in the polycystic ovary syndrome group and 60.0% in the non-polycystic ovary syndrome group, with no significant difference between the two groups.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan. gyn003@poh.osaka-med.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11396371

Citation

Ushiroyama, T, et al. "Effects of Unkei-to, an Herbal Medicine, On Endocrine Function and Ovulation in Women With High Basal Levels of Luteinizing Hormone Secretion." The Journal of Reproductive Medicine, vol. 46, no. 5, 2001, pp. 451-6.
Ushiroyama T, Ikeda A, Sakai M, et al. Effects of unkei-to, an herbal medicine, on endocrine function and ovulation in women with high basal levels of luteinizing hormone secretion. J Reprod Med. 2001;46(5):451-6.
Ushiroyama, T., Ikeda, A., Sakai, M., Hosotani, T., Suzuki, Y., Tsubokura, S., & Ueki, M. (2001). Effects of unkei-to, an herbal medicine, on endocrine function and ovulation in women with high basal levels of luteinizing hormone secretion. The Journal of Reproductive Medicine, 46(5), 451-6.
Ushiroyama T, et al. Effects of Unkei-to, an Herbal Medicine, On Endocrine Function and Ovulation in Women With High Basal Levels of Luteinizing Hormone Secretion. J Reprod Med. 2001;46(5):451-6. PubMed PMID: 11396371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of unkei-to, an herbal medicine, on endocrine function and ovulation in women with high basal levels of luteinizing hormone secretion. AU - Ushiroyama,T, AU - Ikeda,A, AU - Sakai,M, AU - Hosotani,T, AU - Suzuki,Y, AU - Tsubokura,S, AU - Ueki,M, PY - 2001/6/9/pubmed PY - 2001/10/12/medline PY - 2001/6/9/entrez SP - 451 EP - 6 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 46 IS - 5 N2 - OBJECTIVE: To treat anovulatory women with high plasma LH levels with unkei-to. STUDY DESIGN: A total of 100 patients with polycystic ovary syndrome (n = 38) or non-polycystic ovary syndrome (n = 62) were allocated randomly into two groups. Endocrine levels (FSH, LH and estradiol), follicle growth and response to unkei-to were compared for 52 subjects in the unkei-to group and 48 subjects in the control group. RESULTS: Unkei-to induced significant decreases in plasma LH in polycystic ovary syndrome and non-polycystic ovary syndrome with high LH levels. Plasma estradiol levels increased significantly (43.5%) in eight weeks of treatment with unkei-to. Significant development of the dominant follicle was also observed in patients treated with unkei-to. When women suffering from ovulatory failure or irregular menstruation and having high plasma LH concentration were treated with unkei-to for eight weeks, a reduction in the serum LH level of at least 1 SD from baseline was noted in 45.5% of polycystic ovary syndrome patients and in 80.0% of non-polycystic ovary syndrome patients. The mean rate of reduction of serum LH was 22.2 +/- 35.7% in polycystic ovary syndrome patients and 49.7 +/- 15.3% in non-polycystic ovary syndrome patients. This reduction was significant in the non-polycystic ovary syndrome patients (P = .030). The rate of menstrual cycle improvement, including successful ovulation, was 50.0% in the polycystic ovary syndrome group and 60.0% in the non-polycystic ovary syndrome group, with no significant difference between the two groups. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/11396371/Effects_of_unkei_to_an_herbal_medicine_on_endocrine_function_and_ovulation_in_women_with_high_basal_levels_of_luteinizing_hormone_secretion_ L2 - https://medlineplus.gov/polycysticovarysyndrome.html DB - PRIME DP - Unbound Medicine ER -