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Comparison of galactose-1-phosphate uridyl transferase in fetal and adult tissues.
Clin Chim Acta. 1975 May 01; 60(3):281-4.CC

Abstract

Galactose-1-phosphate uridyl transferase, the enzyme deficient in galactosemia, is demonstrated to be present in erythrocytes from fetuses of 12--30 weeks gestation. The specific activity and starch gel electrophoretic pattern of this enzyme in fetal erythrocytes is virtually identical to that found in erythrocytes postnatally. This enzyme was also studied in cultured fibroblasts from skin and amniotic cells and found to have similar specific activity and identical electrophoretic mobility in tissues from both sources. There does not appear to be a fetal isozyme for galactose-1-phosphate uridyl transferase in either erythrocytes or cultured fibroblasts. Thus, with fetal erythrocytes obtained by fetoscopy, it is likely that prenatal diagnosis of galactosemia can be rapidly and reliably accomplished.

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Publisher Full Text

Authors

Hammersen G
No affiliation info available
Levy HL
No affiliation info available
Frigoletto F
No affiliation info available
Mandell R
No affiliation info available

MeSH

AdultAgingCells, CulturedElectrophoresis, Starch GelErythrocytesFemaleFetusFibroblastsGestational AgeHumansIsoenzymesNucleotidyltransferasesPregnancyUTP-Hexose-1-Phosphate Uridylyltransferase

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1139775

Citation

Hammersen, G, et al. "Comparison of Galactose-1-phosphate Uridyl Transferase in Fetal and Adult Tissues." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 60, no. 3, 1975, pp. 281-4.
Hammersen G, Levy HL, Frigoletto F, et al. Comparison of galactose-1-phosphate uridyl transferase in fetal and adult tissues. Clin Chim Acta. 1975;60(3):281-4.
Hammersen, G., Levy, H. L., Frigoletto, F., & Mandell, R. (1975). Comparison of galactose-1-phosphate uridyl transferase in fetal and adult tissues. Clinica Chimica Acta; International Journal of Clinical Chemistry, 60(3), 281-4.
Hammersen G, et al. Comparison of Galactose-1-phosphate Uridyl Transferase in Fetal and Adult Tissues. Clin Chim Acta. 1975 May 1;60(3):281-4. PubMed PMID: 1139775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of galactose-1-phosphate uridyl transferase in fetal and adult tissues. AU - Hammersen,G, AU - Levy,H L, AU - Frigoletto,F, AU - Mandell,R, PY - 1975/5/1/pubmed PY - 1975/5/1/medline PY - 1975/5/1/entrez SP - 281 EP - 4 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin Chim Acta VL - 60 IS - 3 N2 - Galactose-1-phosphate uridyl transferase, the enzyme deficient in galactosemia, is demonstrated to be present in erythrocytes from fetuses of 12--30 weeks gestation. The specific activity and starch gel electrophoretic pattern of this enzyme in fetal erythrocytes is virtually identical to that found in erythrocytes postnatally. This enzyme was also studied in cultured fibroblasts from skin and amniotic cells and found to have similar specific activity and identical electrophoretic mobility in tissues from both sources. There does not appear to be a fetal isozyme for galactose-1-phosphate uridyl transferase in either erythrocytes or cultured fibroblasts. Thus, with fetal erythrocytes obtained by fetoscopy, it is likely that prenatal diagnosis of galactosemia can be rapidly and reliably accomplished. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/1139775/Comparison_of_galactose_1_phosphate_uridyl_transferase_in_fetal_and_adult_tissues_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0009-8981(75)90068-6 DB - PRIME DP - Unbound Medicine ER -