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Evaluation of mutagenic activity of several antimalarial extracts from Eupatorium inulaefolium.
Pharmazie. 2001 May; 56(5):412-4.P

Abstract

Eupatorium inulaefolium is used as an antimalarial agent by traditional healers of the Tumaco region (Nariño-Colombia). Several extracts of this plant have been tested by our laboratory and in vitro antimalarial activity against the FCB-2 strain of Plasmodium falciparum has been confirmed. For this reason, the mutagenic effect of the methanol, dichloromethane, and hexane extracts of Eupatorium inulaefolium (number 83377 university of Antioquia herbarium) were evaluated using the Ames test. None of the extracts evaluated had mutagenic effects on TA-98 or TA-100 strains of Salmonella typhimurium.

Authors+Show Affiliations

Pabón A
Malaria Group, University of Antioquia, Medellín, Colombia.
Lopera T
No affiliation info available
Carmona J
No affiliation info available
Blair S
No affiliation info available

MeSH

AnimalsAntimalarialsBase Pair MismatchDNA, BacterialFrameshift MutationIn Vitro TechniquesMaleMutagenicity TestsMutagensPlant ExtractsPlants, MedicinalRatsSalmonella typhimuriumSolventsSubcellular Fractions

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

11400559

Citation

Pabón, A, et al. "Evaluation of Mutagenic Activity of Several Antimalarial Extracts From Eupatorium Inulaefolium." Die Pharmazie, vol. 56, no. 5, 2001, pp. 412-4.
Pabón A, Lopera T, Carmona J, et al. Evaluation of mutagenic activity of several antimalarial extracts from Eupatorium inulaefolium. Pharmazie. 2001;56(5):412-4.
Pabón, A., Lopera, T., Carmona, J., & Blair, S. (2001). Evaluation of mutagenic activity of several antimalarial extracts from Eupatorium inulaefolium. Die Pharmazie, 56(5), 412-4.
Pabón A, et al. Evaluation of Mutagenic Activity of Several Antimalarial Extracts From Eupatorium Inulaefolium. Pharmazie. 2001;56(5):412-4. PubMed PMID: 11400559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of mutagenic activity of several antimalarial extracts from Eupatorium inulaefolium. AU - Pabón,A, AU - Lopera,T, AU - Carmona,J, AU - Blair,S, PY - 2001/6/13/pubmed PY - 2001/7/6/medline PY - 2001/6/13/entrez SP - 412 EP - 4 JF - Die Pharmazie JO - Pharmazie VL - 56 IS - 5 N2 - Eupatorium inulaefolium is used as an antimalarial agent by traditional healers of the Tumaco region (Nariño-Colombia). Several extracts of this plant have been tested by our laboratory and in vitro antimalarial activity against the FCB-2 strain of Plasmodium falciparum has been confirmed. For this reason, the mutagenic effect of the methanol, dichloromethane, and hexane extracts of Eupatorium inulaefolium (number 83377 university of Antioquia herbarium) were evaluated using the Ames test. None of the extracts evaluated had mutagenic effects on TA-98 or TA-100 strains of Salmonella typhimurium. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/11400559/Evaluation_of_mutagenic_activity_of_several_antimalarial_extracts_from_Eupatorium_inulaefolium_ DB - PRIME DP - Unbound Medicine ER -