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High prevalence of vitamin D deficiency in Japanese female patients with Graves' disease.
Endocr J. 2001 Feb; 48(1):63-9.EJ

Abstract

We reported previously that vitamin D deficiency is a causal mechanism of postoperative tetany in patients with Graves' disease. The aim of the present study was to determine the prevalence of vitamin D deficiency by reviewing serum 25(OH)D levels in 208 patients with Graves' disease (146 women, 62 men) during a 1 year period. Serum 25(OH)D levels were significantly lower (p < 0.001) in female Graves' patients (31.8 +/- 13.3 nmol/l) than in male patients (41.3 +/- 15.0 nmol/l). Vitamin D deficiency (defined as a serum 25(OH)D value below 25 nmol/l) was found in 40% of female patients and in 18% of male patients (p < 0.005). There was a significant seasonal variation in the 25(OH)D concentrations in female patients [amplitude 6.38 (95% CI, 5.42-7.56)], with values below 25 nmol/l found in 58% of female patients during the winter months. There were significant (p < 0.001) differences in serum 25(OH)D levels between age groups in the female patients. The concentrations were lowest in patients in their twenties (25.1 +/- 8.2 nmol/l) and highest in patients in their fifties and sixties (43.2 +/- 13.7 nmol/l). Serum 25(OH)D concentrations might be monitored in patients with Graves' disease during antithyroid drug therapy, and vitamin D and/or calcium supplements are recommended for patients with vitamin D deficiency.

Authors+Show Affiliations

Noguchi Thyroid Clinic and Hospital Foundation, Beppu, Oita, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11403104

Citation

Yamashita, H, et al. "High Prevalence of Vitamin D Deficiency in Japanese Female Patients With Graves' Disease." Endocrine Journal, vol. 48, no. 1, 2001, pp. 63-9.
Yamashita H, Noguchi S, Takatsu K, et al. High prevalence of vitamin D deficiency in Japanese female patients with Graves' disease. Endocr J. 2001;48(1):63-9.
Yamashita, H., Noguchi, S., Takatsu, K., Koike, E., Murakami, T., Watanabe, S., Uchino, S., Yamashita, H., & Kawamoto, H. (2001). High prevalence of vitamin D deficiency in Japanese female patients with Graves' disease. Endocrine Journal, 48(1), 63-9.
Yamashita H, et al. High Prevalence of Vitamin D Deficiency in Japanese Female Patients With Graves' Disease. Endocr J. 2001;48(1):63-9. PubMed PMID: 11403104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High prevalence of vitamin D deficiency in Japanese female patients with Graves' disease. AU - Yamashita,H, AU - Noguchi,S, AU - Takatsu,K, AU - Koike,E, AU - Murakami,T, AU - Watanabe,S, AU - Uchino,S, AU - Yamashita,H, AU - Kawamoto,H, PY - 2001/6/14/pubmed PY - 2001/10/26/medline PY - 2001/6/14/entrez SP - 63 EP - 9 JF - Endocrine journal JO - Endocr J VL - 48 IS - 1 N2 - We reported previously that vitamin D deficiency is a causal mechanism of postoperative tetany in patients with Graves' disease. The aim of the present study was to determine the prevalence of vitamin D deficiency by reviewing serum 25(OH)D levels in 208 patients with Graves' disease (146 women, 62 men) during a 1 year period. Serum 25(OH)D levels were significantly lower (p < 0.001) in female Graves' patients (31.8 +/- 13.3 nmol/l) than in male patients (41.3 +/- 15.0 nmol/l). Vitamin D deficiency (defined as a serum 25(OH)D value below 25 nmol/l) was found in 40% of female patients and in 18% of male patients (p < 0.005). There was a significant seasonal variation in the 25(OH)D concentrations in female patients [amplitude 6.38 (95% CI, 5.42-7.56)], with values below 25 nmol/l found in 58% of female patients during the winter months. There were significant (p < 0.001) differences in serum 25(OH)D levels between age groups in the female patients. The concentrations were lowest in patients in their twenties (25.1 +/- 8.2 nmol/l) and highest in patients in their fifties and sixties (43.2 +/- 13.7 nmol/l). Serum 25(OH)D concentrations might be monitored in patients with Graves' disease during antithyroid drug therapy, and vitamin D and/or calcium supplements are recommended for patients with vitamin D deficiency. SN - 0918-8959 UR - https://www.unboundmedicine.com/medline/citation/11403104/High_prevalence_of_vitamin_D_deficiency_in_Japanese_female_patients_with_Graves'_disease_ L2 - https://joi.jlc.jst.go.jp/JST.Journalarchive/endocrj1993/48.63?from=PubMed DB - PRIME DP - Unbound Medicine ER -