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Fatigue and health profile in sicca syndrome of Sjögren's and non-Sjögren's syndrome origin.
Clin Exp Rheumatol. 2001 May-Jun; 19(3):313-6.CE

Abstract

OBJECTIVE

To assess the health status and fatigue in sicca patients with or without Sjögren's syndrome (SS) and to test whether the immune-inflammatory activity or the extent of the disease predict fatigue in SS.

METHODS

The Medical Outcomes Study Short-Form General Health Survey (MOS SF-36) was used in 1 degree SS (n = 90), 2 degrees SS (n = 24), non-SS patients with sicca symptoms (n = 15) and healthy population controls (n = 126). Laboratory values and clinical findings were used to predict fatigue in SS.

RESULTS

74% of the SS and 80% of the non-SS sicca patients felt themselves tired. Vitality score values were 40.2 +/- 20.3 in 1 degree SS, 42.1 +/- 20.6 in 2 degrees SS and 29.0 +/- 15.8 in non-SS. The health profiles were similar in 1 degree and 2 degrees SS, worse (p < 0.001) than in normal controls, but in most aspects better than in non-SS sicca patients. In SS neither hemoglobin, ESR nor CRP predicted fatigue. Surprisingly, high serum IgG (p < 0.05), antinuclear antibodies (ANA) (p < 0.01) and SS-A antibodies (p < 0.05) values correlated positively with vitality. The number of disease manifestations correlated negatively with vitality (p < 0.004). The total number of disease manifestations, and ANA and/or SS-A autoantibodies were the best predictors of fatigue, but explained it only to 17-57%.

CONCLUSION

Patients with fatigue and perceived ill health but without fibromyalgia had sicca symptoms and low basal tear and salivary secretion rates, indicating that cortical events can lead to a SS-like sicca syndrome. Even in SS fatigue is only in part explained by clinical disease manifestations and laboratory tests assessing inflammation and autoimmunity. Fatigue in both SS and non-SS sicca syndrome more likely correlates to other features, such as neuroendocrine aspects of the disease.

Authors+Show Affiliations

Biomedicum Helsinki, Institute of Biomedicine/Anatomy, University of Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11407086

Citation

Tensing, E K., et al. "Fatigue and Health Profile in Sicca Syndrome of Sjögren's and non-Sjögren's Syndrome Origin." Clinical and Experimental Rheumatology, vol. 19, no. 3, 2001, pp. 313-6.
Tensing EK, Solovieva SA, Tervahartiala T, et al. Fatigue and health profile in sicca syndrome of Sjögren's and non-Sjögren's syndrome origin. Clin Exp Rheumatol. 2001;19(3):313-6.
Tensing, E. K., Solovieva, S. A., Tervahartiala, T., Nordström, D. C., Laine, M., Niissalo, S., & Konttinen, Y. T. (2001). Fatigue and health profile in sicca syndrome of Sjögren's and non-Sjögren's syndrome origin. Clinical and Experimental Rheumatology, 19(3), 313-6.
Tensing EK, et al. Fatigue and Health Profile in Sicca Syndrome of Sjögren's and non-Sjögren's Syndrome Origin. Clin Exp Rheumatol. 2001 May-Jun;19(3):313-6. PubMed PMID: 11407086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatigue and health profile in sicca syndrome of Sjögren's and non-Sjögren's syndrome origin. AU - Tensing,E K, AU - Solovieva,S A, AU - Tervahartiala,T, AU - Nordström,D C, AU - Laine,M, AU - Niissalo,S, AU - Konttinen,Y T, PY - 2001/6/16/pubmed PY - 2001/11/3/medline PY - 2001/6/16/entrez SP - 313 EP - 6 JF - Clinical and experimental rheumatology JO - Clin Exp Rheumatol VL - 19 IS - 3 N2 - OBJECTIVE: To assess the health status and fatigue in sicca patients with or without Sjögren's syndrome (SS) and to test whether the immune-inflammatory activity or the extent of the disease predict fatigue in SS. METHODS: The Medical Outcomes Study Short-Form General Health Survey (MOS SF-36) was used in 1 degree SS (n = 90), 2 degrees SS (n = 24), non-SS patients with sicca symptoms (n = 15) and healthy population controls (n = 126). Laboratory values and clinical findings were used to predict fatigue in SS. RESULTS: 74% of the SS and 80% of the non-SS sicca patients felt themselves tired. Vitality score values were 40.2 +/- 20.3 in 1 degree SS, 42.1 +/- 20.6 in 2 degrees SS and 29.0 +/- 15.8 in non-SS. The health profiles were similar in 1 degree and 2 degrees SS, worse (p < 0.001) than in normal controls, but in most aspects better than in non-SS sicca patients. In SS neither hemoglobin, ESR nor CRP predicted fatigue. Surprisingly, high serum IgG (p < 0.05), antinuclear antibodies (ANA) (p < 0.01) and SS-A antibodies (p < 0.05) values correlated positively with vitality. The number of disease manifestations correlated negatively with vitality (p < 0.004). The total number of disease manifestations, and ANA and/or SS-A autoantibodies were the best predictors of fatigue, but explained it only to 17-57%. CONCLUSION: Patients with fatigue and perceived ill health but without fibromyalgia had sicca symptoms and low basal tear and salivary secretion rates, indicating that cortical events can lead to a SS-like sicca syndrome. Even in SS fatigue is only in part explained by clinical disease manifestations and laboratory tests assessing inflammation and autoimmunity. Fatigue in both SS and non-SS sicca syndrome more likely correlates to other features, such as neuroendocrine aspects of the disease. SN - 0392-856X UR - https://www.unboundmedicine.com/medline/citation/11407086/Fatigue_and_health_profile_in_sicca_syndrome_of_Sjögren's_and_non_Sjögren's_syndrome_origin_ L2 - https://medlineplus.gov/fatigue.html DB - PRIME DP - Unbound Medicine ER -