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PCBs and neurodevelopmental effects in Michigan children: an evaluation of exposure and dose characterization.
Regul Toxicol Pharmacol. 2001 Jun; 33(3):300-12.RT

Abstract

Despite the fact that PCB levels in the general environment have continued to decline over the past decade, concern for potential neurodevelopmental deficits from in utero exposure to these compounds remains unabated. In fact, some regulatory and scientific bodies have concluded that the evidence suggesting that prenatal exposure to PCBs may lead to neurodevelopmental deficits is one of the greatest public health concerns surrounding PCBs. The primary basis for the concern that low-level in utero exposure to PCBs causes neurodevelopmental deficits in children is a series of reports on a cohort of Michigan children presumably exposed to PCBs as a result of their mother's consumption of Great Lakes fish. These children, known collectively as the Jacobson cohort, have been followed from birth to 11 years of age. The investigators following these children concluded that they have demonstrated persistent neurodevelopmental effects in this cohort attributable solely to PCBs. However, a detailed analysis of the cohort's exposure characterization, particularly in the initial reports, reveals considerable uncertainty as to the actual exposure status of mothers characterized as "fish eaters" and their offspring. Failure to adequately characterize the PCB exposure of these mothers, or their children, precludes any causal association between in utero exposure to PCBs and neurodevelopmental deficits.

Authors+Show Affiliations

BBL Sciences, a Division of BBL, Inc., 1203 Governors Square Boulevard, Sixth Floor, Tallahassee, Florida, 32301, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11407933

Citation

Schell, J D., et al. "PCBs and Neurodevelopmental Effects in Michigan Children: an Evaluation of Exposure and Dose Characterization." Regulatory Toxicology and Pharmacology : RTP, vol. 33, no. 3, 2001, pp. 300-12.
Schell JD, Budinsky RA, Wernke MJ. PCBs and neurodevelopmental effects in Michigan children: an evaluation of exposure and dose characterization. Regul Toxicol Pharmacol. 2001;33(3):300-12.
Schell, J. D., Budinsky, R. A., & Wernke, M. J. (2001). PCBs and neurodevelopmental effects in Michigan children: an evaluation of exposure and dose characterization. Regulatory Toxicology and Pharmacology : RTP, 33(3), 300-12.
Schell JD, Budinsky RA, Wernke MJ. PCBs and Neurodevelopmental Effects in Michigan Children: an Evaluation of Exposure and Dose Characterization. Regul Toxicol Pharmacol. 2001;33(3):300-12. PubMed PMID: 11407933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PCBs and neurodevelopmental effects in Michigan children: an evaluation of exposure and dose characterization. AU - Schell,J D,Jr AU - Budinsky,R A, AU - Wernke,M J, PY - 2001/6/16/pubmed PY - 2001/8/10/medline PY - 2001/6/16/entrez SP - 300 EP - 12 JF - Regulatory toxicology and pharmacology : RTP JO - Regul Toxicol Pharmacol VL - 33 IS - 3 N2 - Despite the fact that PCB levels in the general environment have continued to decline over the past decade, concern for potential neurodevelopmental deficits from in utero exposure to these compounds remains unabated. In fact, some regulatory and scientific bodies have concluded that the evidence suggesting that prenatal exposure to PCBs may lead to neurodevelopmental deficits is one of the greatest public health concerns surrounding PCBs. The primary basis for the concern that low-level in utero exposure to PCBs causes neurodevelopmental deficits in children is a series of reports on a cohort of Michigan children presumably exposed to PCBs as a result of their mother's consumption of Great Lakes fish. These children, known collectively as the Jacobson cohort, have been followed from birth to 11 years of age. The investigators following these children concluded that they have demonstrated persistent neurodevelopmental effects in this cohort attributable solely to PCBs. However, a detailed analysis of the cohort's exposure characterization, particularly in the initial reports, reveals considerable uncertainty as to the actual exposure status of mothers characterized as "fish eaters" and their offspring. Failure to adequately characterize the PCB exposure of these mothers, or their children, precludes any causal association between in utero exposure to PCBs and neurodevelopmental deficits. SN - 0273-2300 UR - https://www.unboundmedicine.com/medline/citation/11407933/PCBs_and_neurodevelopmental_effects_in_Michigan_children:_an_evaluation_of_exposure_and_dose_characterization_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0273-2300(01)91475-8 DB - PRIME DP - Unbound Medicine ER -