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Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study.
BMJ 2001; 322(7300):1447-51BMJ

Abstract

OBJECTIVE

To examine the relation of midlife raised blood pressure and serum cholesterol concentrations to Alzheimer's disease in later life.

DESIGN

Prospective, population based study.

SETTING

Populations of Kuopio and Joensuu, eastern Finland.

PARTICIPANTS

Participants were derived from random, population based samples previously studied in a survey carried out in 1972, 1977, 1982, or 1987. After an average of 21 years' follow up, a total of 1449 (73%) participants aged 65-79 took part in the re-examination in 1998.

MAIN OUTCOME MEASURES

Midlife blood pressure and cholesterol concentrations and development of Alzheimer's disease in later life.

RESULTS

People with raised systolic blood pressure (>/=160 mm Hg) or high serum cholesterol concentration (>/=6.5 mmol/l) in midlife had a significantly higher risk of Alzheimer's disease in later life, even after adjustment for age, body mass index, education, vascular events, smoking status, and alcohol consumption, than those with normal systolic blood pressure (odds ratio 2.3, 95% confidence interval 1.0 to 5.5) or serum cholesterol (odds ratio 2.1, 1.0 to 4.4). Participants with both of these risk factors in midlife had a significantly higher risk of developing Alzheimer's disease than those with either of the risk factors alone (odds ratio 3.5, 1.6 to 7.9). Diastolic blood pressure in midlife had no significant effect on the risk of Alzheimer's disease.

CONCLUSION

Raised systolic blood pressure and high serum cholesterol concentration, and in particular the combination of these risks, in midlife increase the risk of Alzheimer's disease in later life.

Authors+Show Affiliations

Department of Neuroscience and Neurology, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland. miia.kivipelto@uku.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11408299

Citation

Kivipelto, M, et al. "Midlife Vascular Risk Factors and Alzheimer's Disease in Later Life: Longitudinal, Population Based Study." BMJ (Clinical Research Ed.), vol. 322, no. 7300, 2001, pp. 1447-51.
Kivipelto M, Helkala EL, Laakso MP, et al. Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study. BMJ. 2001;322(7300):1447-51.
Kivipelto, M., Helkala, E. L., Laakso, M. P., Hänninen, T., Hallikainen, M., Alhainen, K., ... Nissinen, A. (2001). Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study. BMJ (Clinical Research Ed.), 322(7300), pp. 1447-51.
Kivipelto M, et al. Midlife Vascular Risk Factors and Alzheimer's Disease in Later Life: Longitudinal, Population Based Study. BMJ. 2001 Jun 16;322(7300):1447-51. PubMed PMID: 11408299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study. AU - Kivipelto,M, AU - Helkala,E L, AU - Laakso,M P, AU - Hänninen,T, AU - Hallikainen,M, AU - Alhainen,K, AU - Soininen,H, AU - Tuomilehto,J, AU - Nissinen,A, PY - 2001/6/16/pubmed PY - 2001/7/13/medline PY - 2001/6/16/entrez SP - 1447 EP - 51 JF - BMJ (Clinical research ed.) JO - BMJ VL - 322 IS - 7300 N2 - OBJECTIVE: To examine the relation of midlife raised blood pressure and serum cholesterol concentrations to Alzheimer's disease in later life. DESIGN: Prospective, population based study. SETTING: Populations of Kuopio and Joensuu, eastern Finland. PARTICIPANTS: Participants were derived from random, population based samples previously studied in a survey carried out in 1972, 1977, 1982, or 1987. After an average of 21 years' follow up, a total of 1449 (73%) participants aged 65-79 took part in the re-examination in 1998. MAIN OUTCOME MEASURES: Midlife blood pressure and cholesterol concentrations and development of Alzheimer's disease in later life. RESULTS: People with raised systolic blood pressure (>/=160 mm Hg) or high serum cholesterol concentration (>/=6.5 mmol/l) in midlife had a significantly higher risk of Alzheimer's disease in later life, even after adjustment for age, body mass index, education, vascular events, smoking status, and alcohol consumption, than those with normal systolic blood pressure (odds ratio 2.3, 95% confidence interval 1.0 to 5.5) or serum cholesterol (odds ratio 2.1, 1.0 to 4.4). Participants with both of these risk factors in midlife had a significantly higher risk of developing Alzheimer's disease than those with either of the risk factors alone (odds ratio 3.5, 1.6 to 7.9). Diastolic blood pressure in midlife had no significant effect on the risk of Alzheimer's disease. CONCLUSION: Raised systolic blood pressure and high serum cholesterol concentration, and in particular the combination of these risks, in midlife increase the risk of Alzheimer's disease in later life. SN - 0959-8138 UR - https://www.unboundmedicine.com/medline/citation/11408299/Midlife_vascular_risk_factors_and_Alzheimer's_disease_in_later_life:_longitudinal_population_based_study_ L2 - http://www.bmj.com/cgi/pmidlookup?view=long&pmid=11408299 DB - PRIME DP - Unbound Medicine ER -