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Influence of muscle strength and body weight and composition on regional bone mineral density in healthy women aged 60 years and over.
Gerontology. 2001 Jul-Aug; 47(4):207-12.G

Abstract

Although weight, lean mass, fat mass and muscular strength are often found to be intercorrelated, the respective role of each parameter in bone mineral density (BMD) remains unknown in older women. The aim of the present study was to investigate the relationship between body weight and composition and quadriceps strength on femoral neck and lumbar spine BMD in healthy postmenopausal women. The relationship between isokinetic quadriceps strength measured by Biodex and BMD measured by dual energy X-ray absorptiometry was studied in 56 women aged 60-81 (70.5 +/- 6.2) years in multiple regression models adjusted for age, body composition and menopausal treatment. Weight and age were associated with femoral neck BMD (33 and 10% of variance accounted for, respectively) and lumbar spine BMD (23 and 8% of its variance). When body weight and quadriceps strength were excluded from the model, lean mass and age were associated with femoral neck BMD (29 and 14% of variance explained, respectively) and lumbar spine BMD (28 and 11% of variance explained, respectively). When quadriceps strength was entered into the model, it was strongly associated with femoral neck BMD (30% of variance accounted for), in addition to lean mass (9%) and age (7%), whereas it was not associated with lumbar spine BMD. In conclusion, lean mass explains a great part of the strong association between body weight and femoral neck and lumbar spine BMD. Quadriceps strength explains a great part of the association between lean mass and BMD at the femoral neck site but not at the lumbar spine site. These results suggest a site-specific effect of muscular strength on bone and a potential role of the age-related decline of muscle strength in age-related bone loss in postmenopausal women.

Authors+Show Affiliations

Centre de Gérontologie, Clinique Antonin-Balmès, CHU Montpellier, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11408726

Citation

Blain, H, et al. "Influence of Muscle Strength and Body Weight and Composition On Regional Bone Mineral Density in Healthy Women Aged 60 Years and Over." Gerontology, vol. 47, no. 4, 2001, pp. 207-12.
Blain H, Vuillemin A, Teissier A, et al. Influence of muscle strength and body weight and composition on regional bone mineral density in healthy women aged 60 years and over. Gerontology. 2001;47(4):207-12.
Blain, H., Vuillemin, A., Teissier, A., Hanesse, B., Guillemin, F., & Jeandel, C. (2001). Influence of muscle strength and body weight and composition on regional bone mineral density in healthy women aged 60 years and over. Gerontology, 47(4), 207-12.
Blain H, et al. Influence of Muscle Strength and Body Weight and Composition On Regional Bone Mineral Density in Healthy Women Aged 60 Years and Over. Gerontology. 2001 Jul-Aug;47(4):207-12. PubMed PMID: 11408726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of muscle strength and body weight and composition on regional bone mineral density in healthy women aged 60 years and over. AU - Blain,H, AU - Vuillemin,A, AU - Teissier,A, AU - Hanesse,B, AU - Guillemin,F, AU - Jeandel,C, PY - 2001/6/16/pubmed PY - 2001/8/24/medline PY - 2001/6/16/entrez SP - 207 EP - 12 JF - Gerontology JO - Gerontology VL - 47 IS - 4 N2 - Although weight, lean mass, fat mass and muscular strength are often found to be intercorrelated, the respective role of each parameter in bone mineral density (BMD) remains unknown in older women. The aim of the present study was to investigate the relationship between body weight and composition and quadriceps strength on femoral neck and lumbar spine BMD in healthy postmenopausal women. The relationship between isokinetic quadriceps strength measured by Biodex and BMD measured by dual energy X-ray absorptiometry was studied in 56 women aged 60-81 (70.5 +/- 6.2) years in multiple regression models adjusted for age, body composition and menopausal treatment. Weight and age were associated with femoral neck BMD (33 and 10% of variance accounted for, respectively) and lumbar spine BMD (23 and 8% of its variance). When body weight and quadriceps strength were excluded from the model, lean mass and age were associated with femoral neck BMD (29 and 14% of variance explained, respectively) and lumbar spine BMD (28 and 11% of variance explained, respectively). When quadriceps strength was entered into the model, it was strongly associated with femoral neck BMD (30% of variance accounted for), in addition to lean mass (9%) and age (7%), whereas it was not associated with lumbar spine BMD. In conclusion, lean mass explains a great part of the strong association between body weight and femoral neck and lumbar spine BMD. Quadriceps strength explains a great part of the association between lean mass and BMD at the femoral neck site but not at the lumbar spine site. These results suggest a site-specific effect of muscular strength on bone and a potential role of the age-related decline of muscle strength in age-related bone loss in postmenopausal women. SN - 0304-324X UR - https://www.unboundmedicine.com/medline/citation/11408726/Influence_of_muscle_strength_and_body_weight_and_composition_on_regional_bone_mineral_density_in_healthy_women_aged_60_years_and_over_ L2 - https://www.karger.com?DOI=10.1159/000052800 DB - PRIME DP - Unbound Medicine ER -