Tags

Type your tag names separated by a space and hit enter

Co-localization of 5-HT(1B/1D/1F) receptors and glutamate in trigeminal ganglia in rats.
Neuroreport. 2001 Jun 13; 12(8):1589-91.N

Abstract

Anti-migraine triptan drugs are 5-HT(1B/1D) receptor agonists which are thought to block the neurotransmitter/neuropeptide release from sensory nerve terminals and directly constrict blood vessel smooth muscles. In the present study, we have investigated the anatomical basis for a possible modulation of glutamate release from trigeminal ganglion neurons by 5-HT(1B/1D) receptor agonists and by 5-HT1F receptor agonists, using double immunohistochemical staining technique in the rat. The majority of 5-HT1B, 5-HT1D or 5-HT1F receptor positive neurons were also glutamate positive, but both 5-HT1B, 5-HT1D or 5-HT1F receptor single-labeled and glutamate single-labeled neurons were observed. These results suggest that 5-HT(1B/1D/1F) receptor agonists may modulate glutamate release, and that one mechanism of their anti-migraine action could be the blockade of glutamate release.

Authors+Show Affiliations

Department of Pharmacology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11409721

Citation

Ma, Q P.. "Co-localization of 5-HT(1B/1D/1F) Receptors and Glutamate in Trigeminal Ganglia in Rats." Neuroreport, vol. 12, no. 8, 2001, pp. 1589-91.
Ma QP. Co-localization of 5-HT(1B/1D/1F) receptors and glutamate in trigeminal ganglia in rats. Neuroreport. 2001;12(8):1589-91.
Ma, Q. P. (2001). Co-localization of 5-HT(1B/1D/1F) receptors and glutamate in trigeminal ganglia in rats. Neuroreport, 12(8), 1589-91.
Ma QP. Co-localization of 5-HT(1B/1D/1F) Receptors and Glutamate in Trigeminal Ganglia in Rats. Neuroreport. 2001 Jun 13;12(8):1589-91. PubMed PMID: 11409721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Co-localization of 5-HT(1B/1D/1F) receptors and glutamate in trigeminal ganglia in rats. A1 - Ma,Q P, PY - 2001/6/21/pubmed PY - 2002/1/5/medline PY - 2001/6/21/entrez SP - 1589 EP - 91 JF - Neuroreport JO - Neuroreport VL - 12 IS - 8 N2 - Anti-migraine triptan drugs are 5-HT(1B/1D) receptor agonists which are thought to block the neurotransmitter/neuropeptide release from sensory nerve terminals and directly constrict blood vessel smooth muscles. In the present study, we have investigated the anatomical basis for a possible modulation of glutamate release from trigeminal ganglion neurons by 5-HT(1B/1D) receptor agonists and by 5-HT1F receptor agonists, using double immunohistochemical staining technique in the rat. The majority of 5-HT1B, 5-HT1D or 5-HT1F receptor positive neurons were also glutamate positive, but both 5-HT1B, 5-HT1D or 5-HT1F receptor single-labeled and glutamate single-labeled neurons were observed. These results suggest that 5-HT(1B/1D/1F) receptor agonists may modulate glutamate release, and that one mechanism of their anti-migraine action could be the blockade of glutamate release. SN - 0959-4965 UR - https://www.unboundmedicine.com/medline/citation/11409721/Co_localization_of_5_HT_1B/1D/1F__receptors_and_glutamate_in_trigeminal_ganglia_in_rats_ L2 - http://dx.doi.org/10.1097/00001756-200106130-00015 DB - PRIME DP - Unbound Medicine ER -