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Pyridoxine-dependent seizures responding to extremely low-dose pyridoxine.
Dev Med Child Neurol 2001; 43(6):413-5DM

Abstract

We report on a male infant with pyridoxine dependency and seizures from birth, controlled with pharmacological doses of pyridoxine at 4 months of age. Seizures stopped between 30 and 80 days of age when very-low doses of pyridoxine were given in a multivitamin supplement. Daily dose was 0.5 mg that corresponded to 0.08 to 0.16 mg/kg/day when weight gain is considered. In previous reports doses have ranged from 0.2 to 30 mg/kg/day. Another distinctive feature was that this infant went into a coma and developed hypotonia and irregular breathing when pyridoxine was given by enteral tube which has usually been reported when the vitamin is given intravenously. Use of low doses of pyridoxine in multivitamin supplements could be a confounding factor for early diagnosis and appropriate treatment of pyridoxine-dependent seizures.

Authors+Show Affiliations

Hospital Infantil Joana de Gusmio, Serviço de Neurologia, Florianópolis SC, Brasil. egrillo@matrix.com.brNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

11409831

Citation

Grillo, E, et al. "Pyridoxine-dependent Seizures Responding to Extremely Low-dose Pyridoxine." Developmental Medicine and Child Neurology, vol. 43, no. 6, 2001, pp. 413-5.
Grillo E, da Silva RJ, Barbato JH. Pyridoxine-dependent seizures responding to extremely low-dose pyridoxine. Dev Med Child Neurol. 2001;43(6):413-5.
Grillo, E., da Silva, R. J., & Barbato, J. H. (2001). Pyridoxine-dependent seizures responding to extremely low-dose pyridoxine. Developmental Medicine and Child Neurology, 43(6), pp. 413-5.
Grillo E, da Silva RJ, Barbato JH. Pyridoxine-dependent Seizures Responding to Extremely Low-dose Pyridoxine. Dev Med Child Neurol. 2001;43(6):413-5. PubMed PMID: 11409831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pyridoxine-dependent seizures responding to extremely low-dose pyridoxine. AU - Grillo,E, AU - da Silva,R J, AU - Barbato,J H,Jr PY - 2001/6/21/pubmed PY - 2001/7/6/medline PY - 2001/6/21/entrez SP - 413 EP - 5 JF - Developmental medicine and child neurology JO - Dev Med Child Neurol VL - 43 IS - 6 N2 - We report on a male infant with pyridoxine dependency and seizures from birth, controlled with pharmacological doses of pyridoxine at 4 months of age. Seizures stopped between 30 and 80 days of age when very-low doses of pyridoxine were given in a multivitamin supplement. Daily dose was 0.5 mg that corresponded to 0.08 to 0.16 mg/kg/day when weight gain is considered. In previous reports doses have ranged from 0.2 to 30 mg/kg/day. Another distinctive feature was that this infant went into a coma and developed hypotonia and irregular breathing when pyridoxine was given by enteral tube which has usually been reported when the vitamin is given intravenously. Use of low doses of pyridoxine in multivitamin supplements could be a confounding factor for early diagnosis and appropriate treatment of pyridoxine-dependent seizures. SN - 0012-1622 UR - https://www.unboundmedicine.com/medline/citation/11409831/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0012-1622&date=2001&volume=43&issue=6&spage=413 DB - PRIME DP - Unbound Medicine ER -