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Circulation in rats with Guérin carcinoma.
J Appl Physiol. 1975 Apr; 38(4):696-701.JA

Abstract

After implantation of Guérin carcinoma in rats, cardiac output (by Evans-blue dilution), distribution of the organ fractions of cardiac output (by Sapirsteins's isotope indicator fractionation technique), nutritive blood flow and circulatory resistance of the organs (including the tumor) were studied. The following parameters were altered proportionately to the weight of the tumor (0.39-84.0 g): a) weight of gut and carcass diminished; b) cardiac index increased, blood pressure and total peripheral resistance decreased; c) tumor fraction of cardiac output was augmented; d) blood flow of the organs increased and their circulatory resistance decreased. Hematocrit decreased from 47.2 to 31.0% 20 days after tumor implantation. In rats with tumor the changes of blood flow may be conditioned by both anemia and the decrease in organ weight.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1141100

Citation

Takács, L, et al. "Circulation in Rats With Guérin Carcinoma." Journal of Applied Physiology, vol. 38, no. 4, 1975, pp. 696-701.
Takács L, Debreczeni LA, Farsang C. Circulation in rats with Guérin carcinoma. J Appl Physiol. 1975;38(4):696-701.
Takács, L., Debreczeni, L. A., & Farsang, C. (1975). Circulation in rats with Guérin carcinoma. Journal of Applied Physiology, 38(4), 696-701.
Takács L, Debreczeni LA, Farsang C. Circulation in Rats With Guérin Carcinoma. J Appl Physiol. 1975;38(4):696-701. PubMed PMID: 1141100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulation in rats with Guérin carcinoma. AU - Takács,L, AU - Debreczeni,L A, AU - Farsang,C, PY - 1975/4/1/pubmed PY - 1975/4/1/medline PY - 1975/4/1/entrez SP - 696 EP - 701 JF - Journal of applied physiology JO - J Appl Physiol VL - 38 IS - 4 N2 - After implantation of Guérin carcinoma in rats, cardiac output (by Evans-blue dilution), distribution of the organ fractions of cardiac output (by Sapirsteins's isotope indicator fractionation technique), nutritive blood flow and circulatory resistance of the organs (including the tumor) were studied. The following parameters were altered proportionately to the weight of the tumor (0.39-84.0 g): a) weight of gut and carcass diminished; b) cardiac index increased, blood pressure and total peripheral resistance decreased; c) tumor fraction of cardiac output was augmented; d) blood flow of the organs increased and their circulatory resistance decreased. Hematocrit decreased from 47.2 to 31.0% 20 days after tumor implantation. In rats with tumor the changes of blood flow may be conditioned by both anemia and the decrease in organ weight. SN - 0021-8987 UR - https://www.unboundmedicine.com/medline/citation/1141100/Circulation_in_rats_with_Guérin_carcinoma_ DB - PRIME DP - Unbound Medicine ER -