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[Incidence of IgE-mediated allergy to cow's milk proteins in the first year of life].
An Esp Pediatr. 2001 Jun; 54(6):536-9.AE

Abstract

OBJECTIVE

To study the incidence of IgE-mediated allergy to cow's milk proteins during the first year of life.

METHODS

A multicenter, prospective study of newborns selected from different health centers was performed. The newborn infants were followed-up during the first year of life. Newborns with suspected adverse reaction to cow's milk were sent to the referral hospital for diagnostic study. This study was based on clinical history, skin tests (skin prick test) and on determination of specific IgE in serum (Pharmacia CAP system) against cow's milk and its protein fractions. Diagnosis was confirmed by open challenge.

RESULTS

A total of 1,663 newborns were followed-up during the first year of life. Adverse reaction was suspected in 56 infants (3.3%). Allergy to cow's milk proteins was confirmed in 6 infants (0.36 %). Eighty-three percent of (5/6) children with cow's milk allergy had first-degree relatives with atopic disease compared with 19 % of children (329/1657) without cow's milk allergy. Among the entire sample, 26 infants had first-degree relatives with atopic disease and one of these infants (3.8%) developed cow milk allergy. The six children with cow's milk allergy were exclusively breast-fed, and clinical reaction developed within 1 week of the introduction of artificial feeding.

CONCLUSION

The incidence of IgE-mediated allergy to cow's milk was 0.36 %. In infants with two first-degree family members with atopic disease, the probability of developing allergy to cow's milk proteins during the first year of life was 3.8%.

Authors+Show Affiliations

Centro de Salud de Paterna. Valencia. Secciones de Alergia Infantil. Servicios de Pediatría. josesanz@wanadoo.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Multicenter Study

Language

spa

PubMed ID

11412399

Citation

Sanz Ortega, J, et al. "[Incidence of IgE-mediated Allergy to Cow's Milk Proteins in the First Year of Life]." Anales Espanoles De Pediatria, vol. 54, no. 6, 2001, pp. 536-9.
Sanz Ortega J, Martorell Aragonés A, Michavila Gómez A, et al. [Incidence of IgE-mediated allergy to cow's milk proteins in the first year of life]. An Esp Pediatr. 2001;54(6):536-9.
Sanz Ortega, J., Martorell Aragonés, A., Michavila Gómez, A., & Nieto García, A. (2001). [Incidence of IgE-mediated allergy to cow's milk proteins in the first year of life]. Anales Espanoles De Pediatria, 54(6), 536-9.
Sanz Ortega J, et al. [Incidence of IgE-mediated Allergy to Cow's Milk Proteins in the First Year of Life]. An Esp Pediatr. 2001;54(6):536-9. PubMed PMID: 11412399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Incidence of IgE-mediated allergy to cow's milk proteins in the first year of life]. AU - Sanz Ortega,J, AU - Martorell Aragonés,A, AU - Michavila Gómez,A, AU - Nieto García,A, AU - ,, PY - 2001/6/20/pubmed PY - 2002/1/5/medline PY - 2001/6/20/entrez SP - 536 EP - 9 JF - Anales espanoles de pediatria JO - An. Esp. Pediatr. VL - 54 IS - 6 N2 - OBJECTIVE: To study the incidence of IgE-mediated allergy to cow's milk proteins during the first year of life. METHODS: A multicenter, prospective study of newborns selected from different health centers was performed. The newborn infants were followed-up during the first year of life. Newborns with suspected adverse reaction to cow's milk were sent to the referral hospital for diagnostic study. This study was based on clinical history, skin tests (skin prick test) and on determination of specific IgE in serum (Pharmacia CAP system) against cow's milk and its protein fractions. Diagnosis was confirmed by open challenge. RESULTS: A total of 1,663 newborns were followed-up during the first year of life. Adverse reaction was suspected in 56 infants (3.3%). Allergy to cow's milk proteins was confirmed in 6 infants (0.36 %). Eighty-three percent of (5/6) children with cow's milk allergy had first-degree relatives with atopic disease compared with 19 % of children (329/1657) without cow's milk allergy. Among the entire sample, 26 infants had first-degree relatives with atopic disease and one of these infants (3.8%) developed cow milk allergy. The six children with cow's milk allergy were exclusively breast-fed, and clinical reaction developed within 1 week of the introduction of artificial feeding. CONCLUSION: The incidence of IgE-mediated allergy to cow's milk was 0.36 %. In infants with two first-degree family members with atopic disease, the probability of developing allergy to cow's milk proteins during the first year of life was 3.8%. SN - 0302-4342 UR - https://www.unboundmedicine.com/medline/citation/11412399/[Incidence_of_IgE_mediated_allergy_to_cow's_milk_proteins_in_the_first_year_of_life]_ DB - PRIME DP - Unbound Medicine ER -