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[Relationship between delta-aminolevulinic acid dehydratase gene polymorphism and blood levels of lead and zinc protoporphyrin in children exposed to lead].
Zhonghua Yu Fang Yi Xue Za Zhi. 2001 Mar; 35(2):96-7.ZY

Abstract

OBJECTIVE

To explore the associations of polymorphism of delta-aminolevulinic acid dehydratase (ALAD) gene with blood levels of lead and zinc protoporphyrin (ZPP).

METHODS

Blood samples were collected from 370 children exposed to a higher level environmental lead and their blood levels of lead and ZPP, and ALAD genotype were examined. Exposure to lead condition, such as parents' lead exposure and sites of lead source around their residence, and age and sex were matched in ALAD1-1 and ALAD1-2/2-2 subgroups.

RESULTS

Blood lead level was higher in the ALAD1-2/2-2 subgroup than that in the ALAD1-1 children [(2.621 +/- 0.561) mumol/L vs (2.360 +/- 0.596) mumol/L, P = 0.04)]. Blood ZPP level was also higher in with ALAD1-2/2-2 subgroup than that in the ALAD1-1 genotype [(13.07 +/- 9.38) mumol/L vs (9.90 +/- 6.30) mumol/L), P = 0.02)].

CONCLUSION

The results suggest that the ALAD1-2/2-2 genotype may influence the body burden and blood toxicity of lead in high lead exposed children.

Authors+Show Affiliations

Zheng Y
Department of Toxicology, Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing 100050, China.
Wang Y
No affiliation info available
Song W
No affiliation info available

MeSH

ChildEnvironmental ExposureHumansLeadPolymorphism, GeneticPorphobilinogen SynthaseProtoporphyrins

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

11413692

Citation

Zheng, Y, et al. "[Relationship Between Delta-aminolevulinic Acid Dehydratase Gene Polymorphism and Blood Levels of Lead and Zinc Protoporphyrin in Children Exposed to Lead]." Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine], vol. 35, no. 2, 2001, pp. 96-7.
Zheng Y, Wang Y, Song W. [Relationship between delta-aminolevulinic acid dehydratase gene polymorphism and blood levels of lead and zinc protoporphyrin in children exposed to lead]. Zhonghua Yu Fang Yi Xue Za Zhi. 2001;35(2):96-7.
Zheng, Y., Wang, Y., & Song, W. (2001). [Relationship between delta-aminolevulinic acid dehydratase gene polymorphism and blood levels of lead and zinc protoporphyrin in children exposed to lead]. Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine], 35(2), 96-7.
Zheng Y, Wang Y, Song W. [Relationship Between Delta-aminolevulinic Acid Dehydratase Gene Polymorphism and Blood Levels of Lead and Zinc Protoporphyrin in Children Exposed to Lead]. Zhonghua Yu Fang Yi Xue Za Zhi. 2001;35(2):96-7. PubMed PMID: 11413692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relationship between delta-aminolevulinic acid dehydratase gene polymorphism and blood levels of lead and zinc protoporphyrin in children exposed to lead]. AU - Zheng,Y, AU - Wang,Y, AU - Song,W, PY - 2001/6/21/pubmed PY - 2002/10/31/medline PY - 2001/6/21/entrez SP - 96 EP - 7 JF - Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] JO - Zhonghua Yu Fang Yi Xue Za Zhi VL - 35 IS - 2 N2 - OBJECTIVE: To explore the associations of polymorphism of delta-aminolevulinic acid dehydratase (ALAD) gene with blood levels of lead and zinc protoporphyrin (ZPP). METHODS: Blood samples were collected from 370 children exposed to a higher level environmental lead and their blood levels of lead and ZPP, and ALAD genotype were examined. Exposure to lead condition, such as parents' lead exposure and sites of lead source around their residence, and age and sex were matched in ALAD1-1 and ALAD1-2/2-2 subgroups. RESULTS: Blood lead level was higher in the ALAD1-2/2-2 subgroup than that in the ALAD1-1 children [(2.621 +/- 0.561) mumol/L vs (2.360 +/- 0.596) mumol/L, P = 0.04)]. Blood ZPP level was also higher in with ALAD1-2/2-2 subgroup than that in the ALAD1-1 genotype [(13.07 +/- 9.38) mumol/L vs (9.90 +/- 6.30) mumol/L), P = 0.02)]. CONCLUSION: The results suggest that the ALAD1-2/2-2 genotype may influence the body burden and blood toxicity of lead in high lead exposed children. SN - 0253-9624 UR - https://www.unboundmedicine.com/medline/citation/11413692/[Relationship_between_delta_aminolevulinic_acid_dehydratase_gene_polymorphism_and_blood_levels_of_lead_and_zinc_protoporphyrin_in_children_exposed_to_lead]_ DB - PRIME DP - Unbound Medicine ER -