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Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone.
Genomics. 2001 Jun 15; 74(3):342-51.G

Abstract

The MEPE (matrix extracellular phosphoglycoprotein) gene is a strong candidate for the tumor-derived phosphaturic factor in oncogenic hypophosphatemic osteomalacia (OHO). X-linked hypophosphatemia (XLH) is phenotypically similar to OHO and results from mutations in PHEX, a putative metallopeptidase believed to process a factor(s) regulating bone mineralization and renal phosphate reabsorption. Here we report the isolation of the murine homologue of MEPE, from a bone cDNA library, that encodes a protein of 433 amino acids, 92 amino acids shorter than human MEPE. Mepe, like Phex, is expressed by fully differentiated osteoblasts and down-regulated by 1,25-(OH)2D3. In contrast to Phex, Mepe expression is markedly increased during osteoblast-mediated matrix mineralization. Greater than normal Mepe mRNA levels were observed in bone and osteoblasts derived from Hyp mice, the murine homologue of human XLH. Our data provide the first evidence that MEPE/Mepe is expressed by osteoblasts in association with mineralization.

Authors+Show Affiliations

Genetics Unit, Shriners Hospital, Montreal, Quebec, H3G 1A6, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11414762

Citation

Argiro, L, et al. "Mepe, the Gene Encoding a Tumor-secreted Protein in Oncogenic Hypophosphatemic Osteomalacia, Is Expressed in Bone." Genomics, vol. 74, no. 3, 2001, pp. 342-51.
Argiro L, Desbarats M, Glorieux FH, et al. Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. Genomics. 2001;74(3):342-51.
Argiro, L., Desbarats, M., Glorieux, F. H., & Ecarot, B. (2001). Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. Genomics, 74(3), 342-51.
Argiro L, et al. Mepe, the Gene Encoding a Tumor-secreted Protein in Oncogenic Hypophosphatemic Osteomalacia, Is Expressed in Bone. Genomics. 2001 Jun 15;74(3):342-51. PubMed PMID: 11414762.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. AU - Argiro,L, AU - Desbarats,M, AU - Glorieux,F H, AU - Ecarot,B, PY - 2001/6/21/pubmed PY - 2001/9/14/medline PY - 2001/6/21/entrez SP - 342 EP - 51 JF - Genomics JO - Genomics VL - 74 IS - 3 N2 - The MEPE (matrix extracellular phosphoglycoprotein) gene is a strong candidate for the tumor-derived phosphaturic factor in oncogenic hypophosphatemic osteomalacia (OHO). X-linked hypophosphatemia (XLH) is phenotypically similar to OHO and results from mutations in PHEX, a putative metallopeptidase believed to process a factor(s) regulating bone mineralization and renal phosphate reabsorption. Here we report the isolation of the murine homologue of MEPE, from a bone cDNA library, that encodes a protein of 433 amino acids, 92 amino acids shorter than human MEPE. Mepe, like Phex, is expressed by fully differentiated osteoblasts and down-regulated by 1,25-(OH)2D3. In contrast to Phex, Mepe expression is markedly increased during osteoblast-mediated matrix mineralization. Greater than normal Mepe mRNA levels were observed in bone and osteoblasts derived from Hyp mice, the murine homologue of human XLH. Our data provide the first evidence that MEPE/Mepe is expressed by osteoblasts in association with mineralization. SN - 0888-7543 UR - https://www.unboundmedicine.com/medline/citation/11414762/Mepe_the_gene_encoding_a_tumor_secreted_protein_in_oncogenic_hypophosphatemic_osteomalacia_is_expressed_in_bone_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0888-7543(01)96553-X DB - PRIME DP - Unbound Medicine ER -