Tags

Type your tag names separated by a space and hit enter

Malaria chemoprophylaxis in the age of drug resistance. I. Currently recommended drug regimens.
Clin Infect Dis. 2001 Jul 15; 33(2):226-34.CI

Abstract

As international travel becomes increasingly common and resistance to antimalarial drugs escalates, a growing number of travelers are at risk for contracting malaria. Parasite resistance to chloroquine and proguanil and real or perceived intolerance among patients to standard prophylactic agents such as mefloquine have highlighted the need for new antimalarial drugs. Promising new regimens include atovaquone and proguanil, in combination; primaquine; and a related 8-aminoquinoline, tafenoquine. These agents are active against the liver stage of the malaria parasite and therefore can be discontinued shortly after the traveler leaves an area where malaria is endemic, which encourages adherence to the treatment regimen. Part 1 of this series reviews currently recommended chemoprophylactic drug regimens, and part 2 will focus on 8-aminoquinoline drugs.

Authors+Show Affiliations

Centre for Travel and Tropical Medicine, Division of Infectious Diseases, Department of Medicine, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada. kevin.kain@uhn.on.caNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11418883

Citation

Kain, K C., et al. "Malaria Chemoprophylaxis in the Age of Drug Resistance. I. Currently Recommended Drug Regimens." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 33, no. 2, 2001, pp. 226-34.
Kain KC, Shanks GD, Keystone JS. Malaria chemoprophylaxis in the age of drug resistance. I. Currently recommended drug regimens. Clin Infect Dis. 2001;33(2):226-34.
Kain, K. C., Shanks, G. D., & Keystone, J. S. (2001). Malaria chemoprophylaxis in the age of drug resistance. I. Currently recommended drug regimens. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 33(2), 226-34.
Kain KC, Shanks GD, Keystone JS. Malaria Chemoprophylaxis in the Age of Drug Resistance. I. Currently Recommended Drug Regimens. Clin Infect Dis. 2001 Jul 15;33(2):226-34. PubMed PMID: 11418883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Malaria chemoprophylaxis in the age of drug resistance. I. Currently recommended drug regimens. AU - Kain,K C, AU - Shanks,G D, AU - Keystone,J S, Y1 - 2001/06/14/ PY - 2000/12/19/received PY - 2001/02/21/revised PY - 2001/6/22/pubmed PY - 2001/9/14/medline PY - 2001/6/22/entrez SP - 226 EP - 34 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 33 IS - 2 N2 - As international travel becomes increasingly common and resistance to antimalarial drugs escalates, a growing number of travelers are at risk for contracting malaria. Parasite resistance to chloroquine and proguanil and real or perceived intolerance among patients to standard prophylactic agents such as mefloquine have highlighted the need for new antimalarial drugs. Promising new regimens include atovaquone and proguanil, in combination; primaquine; and a related 8-aminoquinoline, tafenoquine. These agents are active against the liver stage of the malaria parasite and therefore can be discontinued shortly after the traveler leaves an area where malaria is endemic, which encourages adherence to the treatment regimen. Part 1 of this series reviews currently recommended chemoprophylactic drug regimens, and part 2 will focus on 8-aminoquinoline drugs. SN - 1058-4838 UR - https://www.unboundmedicine.com/medline/citation/11418883/Malaria_chemoprophylaxis_in_the_age_of_drug_resistance__I__Currently_recommended_drug_regimens_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/321817 DB - PRIME DP - Unbound Medicine ER -