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Hiatal hernia size is the dominant determinant of esophagitis presence and severity in gastroesophageal reflux disease.
Am J Gastroenterol 2001; 96(6):1711-7AJ

Abstract

OBJECTIVE

Although reflux esophagitis is a multifactorial disease, the relative importance of these pathogenetic factors has not been clearly established. In this study, regression analysis was used to model the major determinants of esophagitis in patients with symptomatic gastroesophageal reflux disease (GERD).

METHODS

Sixty-six GERD patients and 16 asymptomatic controls were evaluated. All patients underwent upper endoscopy, esophageal manometry, and 24-h pH monitoring. Esophagrams were performed in 38 of the GERD patients and all controls. Stepwise regression was performed using esophagitis severity as the dependent variable. Logistic regression was performed grouping subjects as controls, nonerosive GERD, or erosive esophagitis.

RESULTS

Hiatal hernia size, lower esophageal sphincter pressure, esophageal acid exposure, and number of reflux episodes >5 min significantly correlated with esophagitis severity. Stepwise regression identified hiatal hernia size (p = 0.0001) and lower esophageal sphincter pressure (p = 0.0024) as significant predictors of esophagitis. Logistic regression also identified hiatal hernia size (chi2 = 17.07, p < 0.0001) and lower esophageal sphincter pressure (chi2 = 5.97, p = 0.0146) as significant predictors of erosive esophagitis.

CONCLUSION

Esophagitis severity is best predicted by hiatal hernia size and lower esophageal sphincter pressure. Of these, hiatal hernia size is the strongest predictor.

Authors+Show Affiliations

Division of Gastroenterology, Northwestern University, Chicago, Illinois, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11419819

Citation

Jones, M P., et al. "Hiatal Hernia Size Is the Dominant Determinant of Esophagitis Presence and Severity in Gastroesophageal Reflux Disease." The American Journal of Gastroenterology, vol. 96, no. 6, 2001, pp. 1711-7.
Jones MP, Sloan SS, Rabine JC, et al. Hiatal hernia size is the dominant determinant of esophagitis presence and severity in gastroesophageal reflux disease. Am J Gastroenterol. 2001;96(6):1711-7.
Jones, M. P., Sloan, S. S., Rabine, J. C., Ebert, C. C., Huang, C. F., & Kahrilas, P. J. (2001). Hiatal hernia size is the dominant determinant of esophagitis presence and severity in gastroesophageal reflux disease. The American Journal of Gastroenterology, 96(6), pp. 1711-7.
Jones MP, et al. Hiatal Hernia Size Is the Dominant Determinant of Esophagitis Presence and Severity in Gastroesophageal Reflux Disease. Am J Gastroenterol. 2001;96(6):1711-7. PubMed PMID: 11419819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hiatal hernia size is the dominant determinant of esophagitis presence and severity in gastroesophageal reflux disease. AU - Jones,M P, AU - Sloan,S S, AU - Rabine,J C, AU - Ebert,C C, AU - Huang,C F, AU - Kahrilas,P J, PY - 2001/6/23/pubmed PY - 2001/8/31/medline PY - 2001/6/23/entrez SP - 1711 EP - 7 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 96 IS - 6 N2 - OBJECTIVE: Although reflux esophagitis is a multifactorial disease, the relative importance of these pathogenetic factors has not been clearly established. In this study, regression analysis was used to model the major determinants of esophagitis in patients with symptomatic gastroesophageal reflux disease (GERD). METHODS: Sixty-six GERD patients and 16 asymptomatic controls were evaluated. All patients underwent upper endoscopy, esophageal manometry, and 24-h pH monitoring. Esophagrams were performed in 38 of the GERD patients and all controls. Stepwise regression was performed using esophagitis severity as the dependent variable. Logistic regression was performed grouping subjects as controls, nonerosive GERD, or erosive esophagitis. RESULTS: Hiatal hernia size, lower esophageal sphincter pressure, esophageal acid exposure, and number of reflux episodes >5 min significantly correlated with esophagitis severity. Stepwise regression identified hiatal hernia size (p = 0.0001) and lower esophageal sphincter pressure (p = 0.0024) as significant predictors of esophagitis. Logistic regression also identified hiatal hernia size (chi2 = 17.07, p < 0.0001) and lower esophageal sphincter pressure (chi2 = 5.97, p = 0.0146) as significant predictors of erosive esophagitis. CONCLUSION: Esophagitis severity is best predicted by hiatal hernia size and lower esophageal sphincter pressure. Of these, hiatal hernia size is the strongest predictor. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/11419819/Hiatal_hernia_size_is_the_dominant_determinant_of_esophagitis_presence_and_severity_in_gastroesophageal_reflux_disease_ L2 - http://Insights.ovid.com/pubmed?pmid=11419819 DB - PRIME DP - Unbound Medicine ER -