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Challenge testing in children with allergy to cow's milk proteins.
Allergol Immunopathol (Madr). 2001 Mar-Apr; 29(2):50-4.AI

Abstract

OBJECTIVES

To evaluate clinical response after challenge testing in infants with allergy to cow's milk proteins at diagnosis and again when these infants were aged 1 year old and had been fed an exclusion diet.

MATERIAL AND METHODS

We performed a prospective study of 49 infants aged less than 6 months with a clinical history suggestive of cow's milk protein allergy, positive skin prick test and specific IgE for alpha-lactalbumin, beta-lactoglobulin and casein. In all children challenge test with cow-milk adapted formula was carried out at diagnosis. The same procedures were repeated when the children were aged 1 year but challenge testing was repeated only in children with a negative skin prick test and specific IgE antibodies to cow's milk proteins.

RESULTS

At diagnosis, challenge tests produced immediate hypersensitivity reactions in 94% of infants. Late reactivity (i.e., more than 2 hours after challenge) was found in only 6% of infants, all of whom presented dyspepsia. When the infants were aged 1 year, and after results of immunological study were negative, a further challenge test was performed in 24 (49%) of lactating infants included in the study. Of these 24 infants, positive challenge was found in 5 (21%). None of the infants presented immediate symptomatology (clinical features appeared 7 days after the reintroduction of cow's milk proteins).

CONCLUSIONS

Ninety-four percent of challenge tests performed at diagnosis provoked immediate reactions. The results of challenge tests after a negative skin prick test in children with normal concentrations of specific IgE were positive in 21% infants, who presented late reactivity (a mean of 7 days after milk ingestion).

Authors+Show Affiliations

Department of Allergy and Clinical Immunology, Integrated Unit Hospital Sant Joan de Déu, University of Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11420027

Citation

Plaza Martín, A M., et al. "Challenge Testing in Children With Allergy to Cow's Milk Proteins." Allergologia Et Immunopathologia, vol. 29, no. 2, 2001, pp. 50-4.
Plaza Martín AM, Martín Mateos MA, Giner Muñoz MT, et al. Challenge testing in children with allergy to cow's milk proteins. Allergol Immunopathol (Madr). 2001;29(2):50-4.
Plaza Martín, A. M., Martín Mateos, M. A., Giner Muñoz, M. T., & Sierra Martínez, J. I. (2001). Challenge testing in children with allergy to cow's milk proteins. Allergologia Et Immunopathologia, 29(2), 50-4.
Plaza Martín AM, et al. Challenge Testing in Children With Allergy to Cow's Milk Proteins. Allergol Immunopathol (Madr). 2001 Mar-Apr;29(2):50-4. PubMed PMID: 11420027.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Challenge testing in children with allergy to cow's milk proteins. AU - Plaza Martín,A M, AU - Martín Mateos,M A, AU - Giner Muñoz,M T, AU - Sierra Martínez,J I, PY - 2001/6/23/pubmed PY - 2001/8/24/medline PY - 2001/6/23/entrez SP - 50 EP - 4 JF - Allergologia et immunopathologia JO - Allergol Immunopathol (Madr) VL - 29 IS - 2 N2 - OBJECTIVES: To evaluate clinical response after challenge testing in infants with allergy to cow's milk proteins at diagnosis and again when these infants were aged 1 year old and had been fed an exclusion diet. MATERIAL AND METHODS: We performed a prospective study of 49 infants aged less than 6 months with a clinical history suggestive of cow's milk protein allergy, positive skin prick test and specific IgE for alpha-lactalbumin, beta-lactoglobulin and casein. In all children challenge test with cow-milk adapted formula was carried out at diagnosis. The same procedures were repeated when the children were aged 1 year but challenge testing was repeated only in children with a negative skin prick test and specific IgE antibodies to cow's milk proteins. RESULTS: At diagnosis, challenge tests produced immediate hypersensitivity reactions in 94% of infants. Late reactivity (i.e., more than 2 hours after challenge) was found in only 6% of infants, all of whom presented dyspepsia. When the infants were aged 1 year, and after results of immunological study were negative, a further challenge test was performed in 24 (49%) of lactating infants included in the study. Of these 24 infants, positive challenge was found in 5 (21%). None of the infants presented immediate symptomatology (clinical features appeared 7 days after the reintroduction of cow's milk proteins). CONCLUSIONS: Ninety-four percent of challenge tests performed at diagnosis provoked immediate reactions. The results of challenge tests after a negative skin prick test in children with normal concentrations of specific IgE were positive in 21% infants, who presented late reactivity (a mean of 7 days after milk ingestion). SN - 0301-0546 UR - https://www.unboundmedicine.com/medline/citation/11420027/Challenge_testing_in_children_with_allergy_to_cow's_milk_proteins_ L2 - http://www.elsevier.es/en/linksolver/ft/ivp/0301-0546/29/50 DB - PRIME DP - Unbound Medicine ER -