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The apolipoprotein E genotype influences the risk for vasospastic angina.
Can J Cardiol. 2001 Jun; 17(6):660-6.CJ

Abstract

It has been suggested that people with the epsilon4 allele of the apolipoprotein E (apoE) polymorphism and the deletion (D) allele of the insertion (I/D) polymorphism of angiotensin-converting enzymes, are at a greater risk for coronary artery disease. However, only a few studies have examined the relationships between vasospastic angina (VSA) and genotype, especially with the apoE polymorphism. In the present study, 76 patients with VSA without significant fixed coronary artery stenosis, 149 patients with ischemic heart disease (IHD) who had 75% or more luminal diameter narrowing and 213 healthy subjects were enrolled. The odds ratio for VSA of the epsilon4 allele carriers relative to the epsilon3/3 allele subjects compared with subjects with IHD and control subjects combined was 0.44 (95% CI 0.21 to 0.93, P=0.021), and that compared with control subjects alone was 0.36 (95% CI 0.17 to 0.78, P=0.005), implying that the presence of the epsilon4 allele indicates resistance to the development of VSA. In contrast, people with the epsilon2 allele showed a tendency to develop VSA more frequently than did patients with IHD (P=0.009), although the frequency of the epsilon2 allele did not differ between patients with VSA and control subjects. On the other hand, no recessive and dominant effects of the D alleles on VSA were found. These findings suggest that the risk of the occurrence of VSA may be reduced by the epsilon4 allele and increased by the epsilon2 allele. The ApoE polymorphism may be associated with IHD and VSA, probably due to the modulation of lipid metabolism.

Authors+Show Affiliations

Kawakami K
Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan.
Okumura K
No affiliation info available
Matsui H
No affiliation info available
Tomida T
No affiliation info available
Kamiya H
No affiliation info available
Osanai H
No affiliation info available
Sakai Y
No affiliation info available
Kanayama H
No affiliation info available
Hayakawa T
No affiliation info available

MeSH

AdultAgedAged, 80 and overAllelesAnalysis of VarianceAngina PectorisApolipoproteins ECase-Control StudiesChi-Square DistributionFemaleGenotypeHumansMaleMiddle AgedPeptidyl-Dipeptidase APolymorphism, GeneticRisk Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11420577

Citation

Kawakami, K, et al. "The Apolipoprotein E Genotype Influences the Risk for Vasospastic Angina." The Canadian Journal of Cardiology, vol. 17, no. 6, 2001, pp. 660-6.
Kawakami K, Okumura K, Matsui H, et al. The apolipoprotein E genotype influences the risk for vasospastic angina. Can J Cardiol. 2001;17(6):660-6.
Kawakami, K., Okumura, K., Matsui, H., Tomida, T., Kamiya, H., Osanai, H., Sakai, Y., Kanayama, H., & Hayakawa, T. (2001). The apolipoprotein E genotype influences the risk for vasospastic angina. The Canadian Journal of Cardiology, 17(6), 660-6.
Kawakami K, et al. The Apolipoprotein E Genotype Influences the Risk for Vasospastic Angina. Can J Cardiol. 2001;17(6):660-6. PubMed PMID: 11420577.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The apolipoprotein E genotype influences the risk for vasospastic angina. AU - Kawakami,K, AU - Okumura,K, AU - Matsui,H, AU - Tomida,T, AU - Kamiya,H, AU - Osanai,H, AU - Sakai,Y, AU - Kanayama,H, AU - Hayakawa,T, PY - 2001/6/23/pubmed PY - 2001/7/28/medline PY - 2001/6/23/entrez SP - 660 EP - 6 JF - The Canadian journal of cardiology JO - Can J Cardiol VL - 17 IS - 6 N2 - It has been suggested that people with the epsilon4 allele of the apolipoprotein E (apoE) polymorphism and the deletion (D) allele of the insertion (I/D) polymorphism of angiotensin-converting enzymes, are at a greater risk for coronary artery disease. However, only a few studies have examined the relationships between vasospastic angina (VSA) and genotype, especially with the apoE polymorphism. In the present study, 76 patients with VSA without significant fixed coronary artery stenosis, 149 patients with ischemic heart disease (IHD) who had 75% or more luminal diameter narrowing and 213 healthy subjects were enrolled. The odds ratio for VSA of the epsilon4 allele carriers relative to the epsilon3/3 allele subjects compared with subjects with IHD and control subjects combined was 0.44 (95% CI 0.21 to 0.93, P=0.021), and that compared with control subjects alone was 0.36 (95% CI 0.17 to 0.78, P=0.005), implying that the presence of the epsilon4 allele indicates resistance to the development of VSA. In contrast, people with the epsilon2 allele showed a tendency to develop VSA more frequently than did patients with IHD (P=0.009), although the frequency of the epsilon2 allele did not differ between patients with VSA and control subjects. On the other hand, no recessive and dominant effects of the D alleles on VSA were found. These findings suggest that the risk of the occurrence of VSA may be reduced by the epsilon4 allele and increased by the epsilon2 allele. The ApoE polymorphism may be associated with IHD and VSA, probably due to the modulation of lipid metabolism. SN - 0828-282X UR - https://www.unboundmedicine.com/medline/citation/11420577/The_apolipoprotein_E_genotype_influences_the_risk_for_vasospastic_angina_ L2 - https://medlineplus.gov/angina.html DB - PRIME DP - Unbound Medicine ER -