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[Homocysteine metabolism and risk of cardiovascular diseases: importance of the nutritional status on folic acid, vitamins B6 and B12].
Rev Invest Clin. 2001 Mar-Apr; 53(2):141-51.RI

Abstract

Homocysteine is a thiol-containing amino acid derived from methionine metabolism that can be degraded through two enzymatic pathways: remethylation and trans-sulfuration. In remethylation, homocysteine regenerates methionine. In the trans-sulfuration pathway, homocysteine forms cysteine. Due to the rapid metabolic utilization, the plasma concentration of this amino acid is low. Homocysteine circulates as free thiol, homocystine, or bound to free cysteine or to cysteine residues of proteins. Genetic defects of some enzymes in the homocysteine metabolism, or nutritional deficiencies of folic acid, vitamin B6 and B12 lead to an increase in homocysteine plasma concentration and is associated to an increment in cardiovascular diseases. On the basis of clinical and epidemiological studies, homocysteine plasma concentration is considered to be an independent risk factor for the development of atherothrombotic and cardiovascular diseases. The present review describes the homocysteine metabolism, the epidemiological evidence showing the association between homocysteine and the incidence of cardiovascular diseases. The mechanisms by which homocysteine produces vascular damage are indicated. Finally, some recommendations are given for the nutritional therapy of patients with hyperhomocysteinemia.

Authors+Show Affiliations

Alemán G
Depto. Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F.
Tovar AR
No affiliation info available
Torres N
No affiliation info available

MeSH

ArteriosclerosisCardiovascular DiseasesCysteineDietary ProteinsFolic AcidHomocysteineHumansHyperhomocysteinemiaMethionineMethylationNutritional StatusPyridoxineRisk FactorsVitamin B 12

Pub Type(s)

English Abstract
Journal Article
Review

Language

spa

PubMed ID

11421110

Citation

Alemán, G, et al. "[Homocysteine Metabolism and Risk of Cardiovascular Diseases: Importance of the Nutritional Status On Folic Acid, Vitamins B6 and B12]." Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion, vol. 53, no. 2, 2001, pp. 141-51.
Alemán G, Tovar AR, Torres N. [Homocysteine metabolism and risk of cardiovascular diseases: importance of the nutritional status on folic acid, vitamins B6 and B12]. Rev Invest Clin. 2001;53(2):141-51.
Alemán, G., Tovar, A. R., & Torres, N. (2001). [Homocysteine metabolism and risk of cardiovascular diseases: importance of the nutritional status on folic acid, vitamins B6 and B12]. Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion, 53(2), 141-51.
Alemán G, Tovar AR, Torres N. [Homocysteine Metabolism and Risk of Cardiovascular Diseases: Importance of the Nutritional Status On Folic Acid, Vitamins B6 and B12]. Rev Invest Clin. 2001 Mar-Apr;53(2):141-51. PubMed PMID: 11421110.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Homocysteine metabolism and risk of cardiovascular diseases: importance of the nutritional status on folic acid, vitamins B6 and B12]. AU - Alemán,G, AU - Tovar,A R, AU - Torres,N, PY - 2001/6/26/pubmed PY - 2001/7/20/medline PY - 2001/6/26/entrez SP - 141 EP - 51 JF - Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion JO - Rev Invest Clin VL - 53 IS - 2 N2 - Homocysteine is a thiol-containing amino acid derived from methionine metabolism that can be degraded through two enzymatic pathways: remethylation and trans-sulfuration. In remethylation, homocysteine regenerates methionine. In the trans-sulfuration pathway, homocysteine forms cysteine. Due to the rapid metabolic utilization, the plasma concentration of this amino acid is low. Homocysteine circulates as free thiol, homocystine, or bound to free cysteine or to cysteine residues of proteins. Genetic defects of some enzymes in the homocysteine metabolism, or nutritional deficiencies of folic acid, vitamin B6 and B12 lead to an increase in homocysteine plasma concentration and is associated to an increment in cardiovascular diseases. On the basis of clinical and epidemiological studies, homocysteine plasma concentration is considered to be an independent risk factor for the development of atherothrombotic and cardiovascular diseases. The present review describes the homocysteine metabolism, the epidemiological evidence showing the association between homocysteine and the incidence of cardiovascular diseases. The mechanisms by which homocysteine produces vascular damage are indicated. Finally, some recommendations are given for the nutritional therapy of patients with hyperhomocysteinemia. SN - 0034-8376 UR - https://www.unboundmedicine.com/medline/citation/11421110/[Homocysteine_metabolism_and_risk_of_cardiovascular_diseases:_importance_of_the_nutritional_status_on_folic_acid_vitamins_B6_and_B12]_ DB - PRIME DP - Unbound Medicine ER -