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[Genetic association between the apolipoprotein E (ApoE) gene alleles and various forms of Alzheimer's disease].
Genetika 2001; 37(4):529-35G

Abstract

Allele epsilon 4 of the apolipoprotein E (APOE) gene is associated with higher risk of Alzheimer's disease (AD) in many, though not all, ethnic groups. The APOE allele and genotype frequency distributions were studied in 207 AD patients without cerebrovascular disorders, 62 AD patients with cerebrovascular disorders (combined AD), and 206 control individuals (ethnic Russians from the Russian population). The frequency of allele epsilon 4 in patients with early-onset and late-onset AD was three times higher than in control individuals (p < 0.000001). Compared with control people, patients with cerebrovascular disorders displayed a twofold higher frequency of allele epsilon 4; the difference between the two groups was significant (p = 0.0019). Relative risk of AD in carriers of allele epsilon 4 was five times higher than in carriers of alleles epsilon 2 and epsilon 3 (p < 0.000001). Allele epsilon 2 had a protective effect with respect to AD onset until 65 years of age (p = 0.015). Thus, APOE allele epsilon 4 proved to be a universal factor of early-onset, late-onset, and combined AD in ethnic Russians from Russia.

Authors+Show Affiliations

Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, 113152 Russia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

11421127

Citation

Korovaĭtseva, G I., et al. "[Genetic Association Between the Apolipoprotein E (ApoE) Gene Alleles and Various Forms of Alzheimer's Disease]." Genetika, vol. 37, no. 4, 2001, pp. 529-35.
Korovaĭtseva GI, Shcherbatykh TV, Selezneva NV, et al. [Genetic association between the apolipoprotein E (ApoE) gene alleles and various forms of Alzheimer's disease]. Genetika. 2001;37(4):529-35.
Korovaĭtseva, G. I., Shcherbatykh, T. V., Selezneva, N. V., Gavrilova, S. I., Golimbet, V. E., Voskresenskaia, N. I., & Rogaev, E. I. (2001). [Genetic association between the apolipoprotein E (ApoE) gene alleles and various forms of Alzheimer's disease]. Genetika, 37(4), pp. 529-35.
Korovaĭtseva GI, et al. [Genetic Association Between the Apolipoprotein E (ApoE) Gene Alleles and Various Forms of Alzheimer's Disease]. Genetika. 2001;37(4):529-35. PubMed PMID: 11421127.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Genetic association between the apolipoprotein E (ApoE) gene alleles and various forms of Alzheimer's disease]. AU - Korovaĭtseva,G I, AU - Shcherbatykh,T V, AU - Selezneva,N V, AU - Gavrilova,S I, AU - Golimbet,V E, AU - Voskresenskaia,N I, AU - Rogaev,E I, PY - 2001/6/26/pubmed PY - 2002/1/5/medline PY - 2001/6/26/entrez SP - 529 EP - 35 JF - Genetika JO - Genetika VL - 37 IS - 4 N2 - Allele epsilon 4 of the apolipoprotein E (APOE) gene is associated with higher risk of Alzheimer's disease (AD) in many, though not all, ethnic groups. The APOE allele and genotype frequency distributions were studied in 207 AD patients without cerebrovascular disorders, 62 AD patients with cerebrovascular disorders (combined AD), and 206 control individuals (ethnic Russians from the Russian population). The frequency of allele epsilon 4 in patients with early-onset and late-onset AD was three times higher than in control individuals (p < 0.000001). Compared with control people, patients with cerebrovascular disorders displayed a twofold higher frequency of allele epsilon 4; the difference between the two groups was significant (p = 0.0019). Relative risk of AD in carriers of allele epsilon 4 was five times higher than in carriers of alleles epsilon 2 and epsilon 3 (p < 0.000001). Allele epsilon 2 had a protective effect with respect to AD onset until 65 years of age (p = 0.015). Thus, APOE allele epsilon 4 proved to be a universal factor of early-onset, late-onset, and combined AD in ethnic Russians from Russia. SN - 0016-6758 UR - https://www.unboundmedicine.com/medline/citation/11421127/[Genetic_association_between_the_apolipoprotein_E__ApoE__gene_alleles_and_various_forms_of_Alzheimer's_disease]_ L2 - https://medlineplus.gov/alzheimersdisease.html DB - PRIME DP - Unbound Medicine ER -