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Five new prenylated stilbenes from the root bark of Lonchocarpus chiricanus.
J Nat Prod. 2001 Jun; 64(6):710-5.JN

Abstract

Besides the known compounds longistylines C (1), D (2), and 3,5-dimethoxystilbene (5), five new prenylated stilbenes, named chiricanines A--E (3, 4, 6--8), have been isolated from the root bark of Lonchocarpus chiricanus. Their structures were resolved on the basis of spectrometric methods including (1)H, (13)C, and 2D NMR experiments and mass spectrometry. Compound 3 was the only prenylated stilbene to demonstrate antifungal effects against Cladosporium cucumerinum. Four of the isolated compounds showed toxic properties against larvae of the yellow fever-transmitting mosquito Aedes aegypti. Compound 5 was found to be as potent as rotenone in larvicidal dilution tests.

Authors+Show Affiliations

Ioset JR
Institut de Pharmacognosie et Phytochimie, Université de Lausanne, BEP, CH-1015 Lausanne, Switzerland.
Marston A
No affiliation info available
Gupta MP
No affiliation info available
Hostettmann K
No affiliation info available

MeSH

AedesAnimalsAntifungal AgentsChromatography, High Pressure LiquidCladosporiumFabaceaeInsecticidesLarvaMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsPanamaPlant EpidermisPlants, MedicinalProtein PrenylationSpectrophotometry, UltravioletStilbenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11421729

Citation

Ioset, J R., et al. "Five New Prenylated Stilbenes From the Root Bark of Lonchocarpus Chiricanus." Journal of Natural Products, vol. 64, no. 6, 2001, pp. 710-5.
Ioset JR, Marston A, Gupta MP, et al. Five new prenylated stilbenes from the root bark of Lonchocarpus chiricanus. J Nat Prod. 2001;64(6):710-5.
Ioset, J. R., Marston, A., Gupta, M. P., & Hostettmann, K. (2001). Five new prenylated stilbenes from the root bark of Lonchocarpus chiricanus. Journal of Natural Products, 64(6), 710-5.
Ioset JR, et al. Five New Prenylated Stilbenes From the Root Bark of Lonchocarpus Chiricanus. J Nat Prod. 2001;64(6):710-5. PubMed PMID: 11421729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Five new prenylated stilbenes from the root bark of Lonchocarpus chiricanus. AU - Ioset,J R, AU - Marston,A, AU - Gupta,M P, AU - Hostettmann,K, PY - 2001/6/26/pubmed PY - 2001/8/31/medline PY - 2001/6/26/entrez SP - 710 EP - 5 JF - Journal of natural products JO - J Nat Prod VL - 64 IS - 6 N2 - Besides the known compounds longistylines C (1), D (2), and 3,5-dimethoxystilbene (5), five new prenylated stilbenes, named chiricanines A--E (3, 4, 6--8), have been isolated from the root bark of Lonchocarpus chiricanus. Their structures were resolved on the basis of spectrometric methods including (1)H, (13)C, and 2D NMR experiments and mass spectrometry. Compound 3 was the only prenylated stilbene to demonstrate antifungal effects against Cladosporium cucumerinum. Four of the isolated compounds showed toxic properties against larvae of the yellow fever-transmitting mosquito Aedes aegypti. Compound 5 was found to be as potent as rotenone in larvicidal dilution tests. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/11421729/Five_new_prenylated_stilbenes_from_the_root_bark_of_Lonchocarpus_chiricanus_ L2 - https://doi.org/10.1021/np000597w DB - PRIME DP - Unbound Medicine ER -