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Effects of dietary protein restriction on fibrinogen and albumin metabolism in nephrotic patients.
Kidney Int. 2001 Jul; 60(1):235-42.KI

Abstract

BACKGROUND

Nephrotic syndrome (NS) is characterized by profound changes in albumin and fibrinogen levels. Dietary protein restriction has been advocated in the treatment of patients with NS, but its effects on albumin and fibrinogen metabolism have not been fully elucidated.

METHODS

We evaluated the effects of dietary protein restriction on endogenous leucine flux (ELF), fibrinogen and albumin metabolism in seven patients with NS who consumed either a normal protein diet (NPD; 1.20 +/- 0.06 g/kg/day), or a low protein diet (LPS; 0.66 +/- 0.04 g/kg/day) for four weeks. Seven normal subjects served as controls. The postabsorptive ELF value, fractional synthesis rate (FSR) and absolute synthesis rate (ASR) of both albumin and fibrinogen were evaluated during the last 120 minutes of a five-hour 5,5,5-D3-L-leucine infusion.

RESULTS

During the NPD regimen. ELF was increased, serum albumin was reduced, plasma fibrinogen was increased, albumin FSR and ASR were both increased, fibrinogen FSR was normal, and fibrinogen ASR was greater in patients with NS compared to controls. In patients with NS the LPD regimen reduced proteinuria, ELF, albumin FSR and ASR, plasma fibrinogen levels, fibrinogen ASR, and increased serum ulbumin levels. Dietary-induced changes in albumin and fibrinogen synthesis were significantly correlated (r = 0.719, P < 0.05).

CONCLUSIONS

Patients with NS treated with LPD show: (1) a reduction of proteinuria, albumin ASR and FSR, with an increase in serum albumin levels and its intravascular pool; (2) a decrease of fibrinogen ASR, with a reduction in both plasma fibrinogen levels and intravascular pool; and (3) a reduced rate of whole body proteolysis.

Authors+Show Affiliations

Istituto di Clinica Medica "L. Condorelli," University of Catania, Catania, Italy. giordmau@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11422756

Citation

Giordano, M, et al. "Effects of Dietary Protein Restriction On Fibrinogen and Albumin Metabolism in Nephrotic Patients." Kidney International, vol. 60, no. 1, 2001, pp. 235-42.
Giordano M, De Feo P, Lucidi P, et al. Effects of dietary protein restriction on fibrinogen and albumin metabolism in nephrotic patients. Kidney Int. 2001;60(1):235-42.
Giordano, M., De Feo, P., Lucidi, P., DePascale, E., Giordano, G., Cirillo, D., Dardo, G., Signorelli, S. S., & Castellino, P. (2001). Effects of dietary protein restriction on fibrinogen and albumin metabolism in nephrotic patients. Kidney International, 60(1), 235-42.
Giordano M, et al. Effects of Dietary Protein Restriction On Fibrinogen and Albumin Metabolism in Nephrotic Patients. Kidney Int. 2001;60(1):235-42. PubMed PMID: 11422756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary protein restriction on fibrinogen and albumin metabolism in nephrotic patients. AU - Giordano,M, AU - De Feo,P, AU - Lucidi,P, AU - DePascale,E, AU - Giordano,G, AU - Cirillo,D, AU - Dardo,G, AU - Signorelli,S S, AU - Castellino,P, PY - 2001/6/26/pubmed PY - 2001/8/31/medline PY - 2001/6/26/entrez SP - 235 EP - 42 JF - Kidney international JO - Kidney Int. VL - 60 IS - 1 N2 - BACKGROUND: Nephrotic syndrome (NS) is characterized by profound changes in albumin and fibrinogen levels. Dietary protein restriction has been advocated in the treatment of patients with NS, but its effects on albumin and fibrinogen metabolism have not been fully elucidated. METHODS: We evaluated the effects of dietary protein restriction on endogenous leucine flux (ELF), fibrinogen and albumin metabolism in seven patients with NS who consumed either a normal protein diet (NPD; 1.20 +/- 0.06 g/kg/day), or a low protein diet (LPS; 0.66 +/- 0.04 g/kg/day) for four weeks. Seven normal subjects served as controls. The postabsorptive ELF value, fractional synthesis rate (FSR) and absolute synthesis rate (ASR) of both albumin and fibrinogen were evaluated during the last 120 minutes of a five-hour 5,5,5-D3-L-leucine infusion. RESULTS: During the NPD regimen. ELF was increased, serum albumin was reduced, plasma fibrinogen was increased, albumin FSR and ASR were both increased, fibrinogen FSR was normal, and fibrinogen ASR was greater in patients with NS compared to controls. In patients with NS the LPD regimen reduced proteinuria, ELF, albumin FSR and ASR, plasma fibrinogen levels, fibrinogen ASR, and increased serum ulbumin levels. Dietary-induced changes in albumin and fibrinogen synthesis were significantly correlated (r = 0.719, P < 0.05). CONCLUSIONS: Patients with NS treated with LPD show: (1) a reduction of proteinuria, albumin ASR and FSR, with an increase in serum albumin levels and its intravascular pool; (2) a decrease of fibrinogen ASR, with a reduction in both plasma fibrinogen levels and intravascular pool; and (3) a reduced rate of whole body proteolysis. SN - 0085-2538 UR - https://www.unboundmedicine.com/medline/citation/11422756/Effects_of_dietary_protein_restriction_on_fibrinogen_and_albumin_metabolism_in_nephrotic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0085-2538(15)47839-1 DB - PRIME DP - Unbound Medicine ER -