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Antioxidative power of plant oils in humans: the influence of alpha- and gamma-tocopherol.
Ann Nutr Metab. 2001; 45(3):110-5.AN

Abstract

BACKGROUND

The daily diet is usually comprised of a varying antioxidant and fatty acid content acquired from plant oils. The present study was performed to evaluate the antioxidative effects of a plant oil mixture rich in alpha-tocopherol (olive/sunflower oil) in comparison with a single gamma-tocopherol-rich corn oil used in a normal, balanced human diet.

METHODS

In the context of a double-blind study 28 healthy nonsmoking male volunteers aged between 19 and 31 years were investigated. After 2 weeks of adjustment on a mixed, balanced diet (average 11.6 MJ, average fat intake approximately 105 g/day), a 2-week test period with a diet of 80 g corn oil (CO)/day vs. a mixture of 68 g olive and 12 g sunflower oil/day (MO; total 80 g) as the main fat source, was followed by a crossover after 2 weeks. Blood samples were collected at the beginning of the study and at 2-week intervals.

RESULTS

The main carriers of tocopherol in blood are low-density lipoproteins (LDLs). A highly significant correlation (r2 = 0.73, p < 0.001) was found between plasma and LDL gamma-tocopherol concentrations in the CO group, and a significant correlation was found between plasma and LDL alpha-tocopherol concentrations only in the MO group. Plasma and LDL total antioxidative capacity values could only be improved insignificantly in both groups to comparable extents, although the MO group had a twofold higher alpha-tocopherol equivalent/diene equivalent ratio (1.13 mg/g) than the CO group (0.55 mg/g).

CONCLUSION

In spite of the higher P/S ratio (CO 4.2 vs. MO 1.2) and lower alpha-tocopherol equivalent/diene equivalent ratio, the antioxidant potential of CO in vivo (total antioxidative capacity in plasma and LDL) was as efficient as the MO. This positive finding might be explained by a synergism between alpha- and gamma-tocopherol in the CO diet.

Authors+Show Affiliations

Institute of Nutritional Sciences, University of Vienna, Austria.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11423702

Citation

Tomasch, R, et al. "Antioxidative Power of Plant Oils in Humans: the Influence of Alpha- and Gamma-tocopherol." Annals of Nutrition & Metabolism, vol. 45, no. 3, 2001, pp. 110-5.
Tomasch R, Wagner KH, Elmadfa I. Antioxidative power of plant oils in humans: the influence of alpha- and gamma-tocopherol. Ann Nutr Metab. 2001;45(3):110-5.
Tomasch, R., Wagner, K. H., & Elmadfa, I. (2001). Antioxidative power of plant oils in humans: the influence of alpha- and gamma-tocopherol. Annals of Nutrition & Metabolism, 45(3), 110-5.
Tomasch R, Wagner KH, Elmadfa I. Antioxidative Power of Plant Oils in Humans: the Influence of Alpha- and Gamma-tocopherol. Ann Nutr Metab. 2001;45(3):110-5. PubMed PMID: 11423702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidative power of plant oils in humans: the influence of alpha- and gamma-tocopherol. AU - Tomasch,R, AU - Wagner,K H, AU - Elmadfa,I, PY - 2001/6/26/pubmed PY - 2001/8/10/medline PY - 2001/6/26/entrez SP - 110 EP - 5 JF - Annals of nutrition & metabolism JO - Ann Nutr Metab VL - 45 IS - 3 N2 - BACKGROUND: The daily diet is usually comprised of a varying antioxidant and fatty acid content acquired from plant oils. The present study was performed to evaluate the antioxidative effects of a plant oil mixture rich in alpha-tocopherol (olive/sunflower oil) in comparison with a single gamma-tocopherol-rich corn oil used in a normal, balanced human diet. METHODS: In the context of a double-blind study 28 healthy nonsmoking male volunteers aged between 19 and 31 years were investigated. After 2 weeks of adjustment on a mixed, balanced diet (average 11.6 MJ, average fat intake approximately 105 g/day), a 2-week test period with a diet of 80 g corn oil (CO)/day vs. a mixture of 68 g olive and 12 g sunflower oil/day (MO; total 80 g) as the main fat source, was followed by a crossover after 2 weeks. Blood samples were collected at the beginning of the study and at 2-week intervals. RESULTS: The main carriers of tocopherol in blood are low-density lipoproteins (LDLs). A highly significant correlation (r2 = 0.73, p < 0.001) was found between plasma and LDL gamma-tocopherol concentrations in the CO group, and a significant correlation was found between plasma and LDL alpha-tocopherol concentrations only in the MO group. Plasma and LDL total antioxidative capacity values could only be improved insignificantly in both groups to comparable extents, although the MO group had a twofold higher alpha-tocopherol equivalent/diene equivalent ratio (1.13 mg/g) than the CO group (0.55 mg/g). CONCLUSION: In spite of the higher P/S ratio (CO 4.2 vs. MO 1.2) and lower alpha-tocopherol equivalent/diene equivalent ratio, the antioxidant potential of CO in vivo (total antioxidative capacity in plasma and LDL) was as efficient as the MO. This positive finding might be explained by a synergism between alpha- and gamma-tocopherol in the CO diet. SN - 0250-6807 UR - https://www.unboundmedicine.com/medline/citation/11423702/Antioxidative_power_of_plant_oils_in_humans:_the_influence_of_alpha__and_gamma_tocopherol_ L2 - https://www.karger.com?DOI=10.1159/000046715 DB - PRIME DP - Unbound Medicine ER -