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Visceral Leishmaniasis in children in the Yemen.
Saudi Med J. 2001 Jun; 22(6):516-9.SM

Abstract

OBJECTIVE

The clinical presentation and duration of therapy for visceral leishmaniasis varies in different countries. The sodium stibogluconate is costly, and a trial of short course therapy has not yet been studied in Hajjah governorate. The aim of this study was to evaluate the efficacy of a 20 days regimen of sodium stibogluconate and to ascertain the epidemiological, clinical and laboratory features of visceral leishmaniasis in children.

METHODS

This was a prospective hospital-based study in Hajjah Governorate, Republic of Yemen. Children of 12 years of age or less with a confirmed diagnosis were included. Sodium stibogluconate was given in a dose of 15mg/kg/dose daily for 20 days, then the patients were re-evaluated and the data required for achieving the other objective was collected.

RESULTS

Thirty-two patients fulfilled the inclusion criteria. The age ranged from 12 months to 144 months (67.7 +/- 35). Females formed 53% of this criteria. The duration of symptoms ranged from 2 weeks to 116 weeks. Fever, fatigability and abdominal distension were the most common symptoms. The hematological findings showed anemia in all patients, leukopenia in 81% and thrombocytopenia in 56%. Formol gel test was negative in 20 patients (63%). Malaria smear was positive in 11 patients (34%). Splenic aspiration was carried out in 25 patients (78%) and bone marrow aspiration in 7 patients (22%). Blood transfusion were required for 24 patients (73%). After 20 days treatment with pentostam, 20 patients (63%) came for follow-up and re-tested for parasitological cure. Half of those were still positive for leishmania donovan bodies. The mortality rate was 5%.

CONCLUSION

The clinical features were of the Mediterranean type. Twenty days treatment with sodium stibogluconate was not adequate.

Authors+Show Affiliations

Department of Pediatrics, Saudi Hospital at Hajjh, Republic of Yemen. alo@y.net.yeNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

11426243

Citation

Haidar, N A., et al. "Visceral Leishmaniasis in Children in the Yemen." Saudi Medical Journal, vol. 22, no. 6, 2001, pp. 516-9.
Haidar NA, Diab AB, El-Sheik AM. Visceral Leishmaniasis in children in the Yemen. Saudi Med J. 2001;22(6):516-9.
Haidar, N. A., Diab, A. B., & El-Sheik, A. M. (2001). Visceral Leishmaniasis in children in the Yemen. Saudi Medical Journal, 22(6), 516-9.
Haidar NA, Diab AB, El-Sheik AM. Visceral Leishmaniasis in Children in the Yemen. Saudi Med J. 2001;22(6):516-9. PubMed PMID: 11426243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Visceral Leishmaniasis in children in the Yemen. AU - Haidar,N A, AU - Diab,A B, AU - El-Sheik,A M, PY - 2001/6/27/pubmed PY - 2007/10/13/medline PY - 2001/6/27/entrez SP - 516 EP - 9 JF - Saudi medical journal JO - Saudi Med J VL - 22 IS - 6 N2 - OBJECTIVE: The clinical presentation and duration of therapy for visceral leishmaniasis varies in different countries. The sodium stibogluconate is costly, and a trial of short course therapy has not yet been studied in Hajjah governorate. The aim of this study was to evaluate the efficacy of a 20 days regimen of sodium stibogluconate and to ascertain the epidemiological, clinical and laboratory features of visceral leishmaniasis in children. METHODS: This was a prospective hospital-based study in Hajjah Governorate, Republic of Yemen. Children of 12 years of age or less with a confirmed diagnosis were included. Sodium stibogluconate was given in a dose of 15mg/kg/dose daily for 20 days, then the patients were re-evaluated and the data required for achieving the other objective was collected. RESULTS: Thirty-two patients fulfilled the inclusion criteria. The age ranged from 12 months to 144 months (67.7 +/- 35). Females formed 53% of this criteria. The duration of symptoms ranged from 2 weeks to 116 weeks. Fever, fatigability and abdominal distension were the most common symptoms. The hematological findings showed anemia in all patients, leukopenia in 81% and thrombocytopenia in 56%. Formol gel test was negative in 20 patients (63%). Malaria smear was positive in 11 patients (34%). Splenic aspiration was carried out in 25 patients (78%) and bone marrow aspiration in 7 patients (22%). Blood transfusion were required for 24 patients (73%). After 20 days treatment with pentostam, 20 patients (63%) came for follow-up and re-tested for parasitological cure. Half of those were still positive for leishmania donovan bodies. The mortality rate was 5%. CONCLUSION: The clinical features were of the Mediterranean type. Twenty days treatment with sodium stibogluconate was not adequate. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/11426243/Visceral_Leishmaniasis_in_children_in_the_Yemen_ L2 - http://www.diseaseinfosearch.org/result/4166 DB - PRIME DP - Unbound Medicine ER -