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Interaction of the common apolipoprotein C-III (APOC3 -482C > T) and hepatic lipase (LIPC -514C > T) promoter variants affects glucose tolerance in young adults. European Atherosclerosis Research Study II (EARS-II).
Ann Hum Genet. 2001 May; 65(Pt 3):237-43.AH

Abstract

Both hepatic lipase (HL) and apolipoprotein C-III (apoC-III) influence lipid metabolism. Common variation in promoters of both genes, LIPC -514C > T and APOC3 -482C > T, respectively, have been shown to affect plasma lipids and lipoproteins and glucose tolerance. We studied the interaction between both variants on parameters of glucose tolerance and lipid metabolism in 714 healthy young males participating in the second European Atherosclerosis Research Study (EARS-II). Approximately 18% of the subjects were carriers of at least one rare LIPC and APOC3 allele. These subjects exhibited, after fasting and oral fat loading, the highest values of triglyceride-rich lipoproteins, but there was no significant interactive effect on any lipid variable. However, interaction occurred on basal diastolic blood pressure (p =0.036) and, during oral glucose tolerance testing, on peak (p = 0.0065) and area under the curve for glucose (p =0.049), and insulin (p = 0.035). This resulted in the highest diastolic blood pressure and lowest glucose tolerance in carriers of at least one rare allele of both genes. Thus gene:gene interaction between LIPC and APOC3, even in these healthy young males, leads to changes in parameters that are typically characteristic of Syndrome-X.

Authors+Show Affiliations

Department of Internal Medicien, Erasmus University, Rotterdam, The Netherlands. jansen@bc1.fgg.eur.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11427182

Citation

Jansen, H, et al. "Interaction of the Common Apolipoprotein C-III (APOC3 -482C > T) and Hepatic Lipase (LIPC -514C > T) Promoter Variants Affects Glucose Tolerance in Young Adults. European Atherosclerosis Research Study II (EARS-II)." Annals of Human Genetics, vol. 65, no. Pt 3, 2001, pp. 237-43.
Jansen H, Waterworth DM, Nicaud V, et al. Interaction of the common apolipoprotein C-III (APOC3 -482C > T) and hepatic lipase (LIPC -514C > T) promoter variants affects glucose tolerance in young adults. European Atherosclerosis Research Study II (EARS-II). Ann Hum Genet. 2001;65(Pt 3):237-43.
Jansen, H., Waterworth, D. M., Nicaud, V., Ehnholm, C., & Talmud, P. J. (2001). Interaction of the common apolipoprotein C-III (APOC3 -482C > T) and hepatic lipase (LIPC -514C > T) promoter variants affects glucose tolerance in young adults. European Atherosclerosis Research Study II (EARS-II). Annals of Human Genetics, 65(Pt 3), 237-43. https://doi.org/10.1017/S0003480001008612
Jansen H, et al. Interaction of the Common Apolipoprotein C-III (APOC3 -482C > T) and Hepatic Lipase (LIPC -514C > T) Promoter Variants Affects Glucose Tolerance in Young Adults. European Atherosclerosis Research Study II (EARS-II). Ann Hum Genet. 2001;65(Pt 3):237-43. PubMed PMID: 11427182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction of the common apolipoprotein C-III (APOC3 -482C > T) and hepatic lipase (LIPC -514C > T) promoter variants affects glucose tolerance in young adults. European Atherosclerosis Research Study II (EARS-II). AU - Jansen,H, AU - Waterworth,D M, AU - Nicaud,V, AU - Ehnholm,C, AU - Talmud,P J, AU - ,, PY - 2000/11/20/received PY - 2001/6/28/pubmed PY - 2001/9/8/medline PY - 2001/6/28/entrez SP - 237 EP - 43 JF - Annals of human genetics JO - Ann Hum Genet VL - 65 IS - Pt 3 N2 - Both hepatic lipase (HL) and apolipoprotein C-III (apoC-III) influence lipid metabolism. Common variation in promoters of both genes, LIPC -514C > T and APOC3 -482C > T, respectively, have been shown to affect plasma lipids and lipoproteins and glucose tolerance. We studied the interaction between both variants on parameters of glucose tolerance and lipid metabolism in 714 healthy young males participating in the second European Atherosclerosis Research Study (EARS-II). Approximately 18% of the subjects were carriers of at least one rare LIPC and APOC3 allele. These subjects exhibited, after fasting and oral fat loading, the highest values of triglyceride-rich lipoproteins, but there was no significant interactive effect on any lipid variable. However, interaction occurred on basal diastolic blood pressure (p =0.036) and, during oral glucose tolerance testing, on peak (p = 0.0065) and area under the curve for glucose (p =0.049), and insulin (p = 0.035). This resulted in the highest diastolic blood pressure and lowest glucose tolerance in carriers of at least one rare allele of both genes. Thus gene:gene interaction between LIPC and APOC3, even in these healthy young males, leads to changes in parameters that are typically characteristic of Syndrome-X. SN - 0003-4800 UR - https://www.unboundmedicine.com/medline/citation/11427182/Interaction_of_the_common_apolipoprotein_C_III__APOC3__482C_>_T__and_hepatic_lipase__LIPC__514C_>_T__promoter_variants_affects_glucose_tolerance_in_young_adults__European_Atherosclerosis_Research_Study_II__EARS_II__ L2 - https://doi.org/10.1017/S0003480001008612 DB - PRIME DP - Unbound Medicine ER -