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Patient-controlled sedation with propofol for colonoscopy.
Gastrointest Endosc. 2001 Jul; 54(1):8-13.GE

Abstract

BACKGROUND

Patient-controlled sedation (PCS) allows the patient to titrate the dosage of sedative drugs according to need.

METHODS

To compare the efficacy of PCS by using propofol with anesthetist-administered midazolam during colonoscopy, 88 patients were randomized to receive either intravenous midazolam 0.05 mg/kg bolus (1 mg increments as required) or propofol PCS (0.3 mg/kg bolus, zero lockout). Heart and respiratory rates, blood pressure, and oxygen saturation were monitored. Patient cooperation, endoscopist satisfaction, and level of sedation were scored. Patient satisfaction was assessed by questionnaire. To correct for multiple testing of data, statistical significance was asserted only for individually stated p values with p < 0.01.

RESULTS

Oxygen saturation and hemodynamics were stable in both groups. Better patient cooperation (good vs. minimal; p = 0.008) and higher endoscopist satisfaction (very good vs. good; p = 0.001) were achieved with PCS. Although more sedated intraoperatively (sedation score 4 vs. 2; p = 0.03 for a single test of hypothesis; correction for multiple testing of data removes this significance), patients in the propofol PCS group were more alert by 30 minutes and discharged earlier (mean and SD times were 43.3 [12.1] min compared with 61.0 [29.7] min; p = 0.001.) More patients in the PCS group (86 vs. 6l%; p < 0.001) were satisfied with their overall level of comfort.

CONCLUSION

PCS with propofol is effective and results in high patient satisfaction and faster discharge.

Authors+Show Affiliations

Department of Anaesthesia and Surgical Intensive Care, Singapore General Hospital, Singapore.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11427834

Citation

Ng, J M., et al. "Patient-controlled Sedation With Propofol for Colonoscopy." Gastrointestinal Endoscopy, vol. 54, no. 1, 2001, pp. 8-13.
Ng JM, Kong CF, Nyam D. Patient-controlled sedation with propofol for colonoscopy. Gastrointest Endosc. 2001;54(1):8-13.
Ng, J. M., Kong, C. F., & Nyam, D. (2001). Patient-controlled sedation with propofol for colonoscopy. Gastrointestinal Endoscopy, 54(1), 8-13.
Ng JM, Kong CF, Nyam D. Patient-controlled Sedation With Propofol for Colonoscopy. Gastrointest Endosc. 2001;54(1):8-13. PubMed PMID: 11427834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patient-controlled sedation with propofol for colonoscopy. AU - Ng,J M, AU - Kong,C F, AU - Nyam,D, PY - 2001/6/28/pubmed PY - 2001/8/31/medline PY - 2001/6/28/entrez SP - 8 EP - 13 JF - Gastrointestinal endoscopy JO - Gastrointest Endosc VL - 54 IS - 1 N2 - BACKGROUND: Patient-controlled sedation (PCS) allows the patient to titrate the dosage of sedative drugs according to need. METHODS: To compare the efficacy of PCS by using propofol with anesthetist-administered midazolam during colonoscopy, 88 patients were randomized to receive either intravenous midazolam 0.05 mg/kg bolus (1 mg increments as required) or propofol PCS (0.3 mg/kg bolus, zero lockout). Heart and respiratory rates, blood pressure, and oxygen saturation were monitored. Patient cooperation, endoscopist satisfaction, and level of sedation were scored. Patient satisfaction was assessed by questionnaire. To correct for multiple testing of data, statistical significance was asserted only for individually stated p values with p < 0.01. RESULTS: Oxygen saturation and hemodynamics were stable in both groups. Better patient cooperation (good vs. minimal; p = 0.008) and higher endoscopist satisfaction (very good vs. good; p = 0.001) were achieved with PCS. Although more sedated intraoperatively (sedation score 4 vs. 2; p = 0.03 for a single test of hypothesis; correction for multiple testing of data removes this significance), patients in the propofol PCS group were more alert by 30 minutes and discharged earlier (mean and SD times were 43.3 [12.1] min compared with 61.0 [29.7] min; p = 0.001.) More patients in the PCS group (86 vs. 6l%; p < 0.001) were satisfied with their overall level of comfort. CONCLUSION: PCS with propofol is effective and results in high patient satisfaction and faster discharge. SN - 0016-5107 UR - https://www.unboundmedicine.com/medline/citation/11427834/Patient_controlled_sedation_with_propofol_for_colonoscopy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5107(01)59586-3 DB - PRIME DP - Unbound Medicine ER -