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Prevention of pneumococcal disease in children. Pneumococcal conjugate vaccines: their use globally could have a major impact on public health.
Acta Paediatr. 2001 May; 90(5):473-6.AP

Abstract

Pneumococcal disease is a major cause of morbidity and mortality in infants and young children worldwide. New pneumococcal conjugate vaccines include 7 to 11 serotypes, which are the most common cause of paediatric disease in most parts of the world. The efficacy of a 7-valent conjugate vaccine was 97.4% (95% CI, 82.7-99.9) against invasive pneumococcal disease, and 57% (95% CI, 44-67) against otitis media, caused by vaccine serotypes. Evidence shows that the vaccine has the potential to prevent pneumonia. Pneumococcal conjugate vaccination has also been shown to reduce nasopharyngeal carriage of vaccine serotypes (particularly serotypes associated with antibiotic resistance). Thus widespread use of pneumococcal conjugate vaccine could substantially reduce the burden of invasive disease and would have the potential to control the global spread of antibiotic resistance in pneumococci.

CONCLUSION

It is important that these highly effective vaccines should be made available to children in the developing countries.

Authors+Show Affiliations

University of Edinburgh, Public Health Sciences, Scotland. Moe.Kyaw@scieh.csa.scot.nhs.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11430703

Citation

Kyaw, M H., et al. "Prevention of Pneumococcal Disease in Children. Pneumococcal Conjugate Vaccines: Their Use Globally Could Have a Major Impact On Public Health." Acta Paediatrica (Oslo, Norway : 1992), vol. 90, no. 5, 2001, pp. 473-6.
Kyaw MH, Jones IG, Campbell H. Prevention of pneumococcal disease in children. Pneumococcal conjugate vaccines: their use globally could have a major impact on public health. Acta Paediatr. 2001;90(5):473-6.
Kyaw, M. H., Jones, I. G., & Campbell, H. (2001). Prevention of pneumococcal disease in children. Pneumococcal conjugate vaccines: their use globally could have a major impact on public health. Acta Paediatrica (Oslo, Norway : 1992), 90(5), 473-6.
Kyaw MH, Jones IG, Campbell H. Prevention of Pneumococcal Disease in Children. Pneumococcal Conjugate Vaccines: Their Use Globally Could Have a Major Impact On Public Health. Acta Paediatr. 2001;90(5):473-6. PubMed PMID: 11430703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of pneumococcal disease in children. Pneumococcal conjugate vaccines: their use globally could have a major impact on public health. AU - Kyaw,M H, AU - Jones,I G, AU - Campbell,H, PY - 2001/6/30/pubmed PY - 2002/1/5/medline PY - 2001/6/30/entrez SP - 473 EP - 6 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr VL - 90 IS - 5 N2 - UNLABELLED: Pneumococcal disease is a major cause of morbidity and mortality in infants and young children worldwide. New pneumococcal conjugate vaccines include 7 to 11 serotypes, which are the most common cause of paediatric disease in most parts of the world. The efficacy of a 7-valent conjugate vaccine was 97.4% (95% CI, 82.7-99.9) against invasive pneumococcal disease, and 57% (95% CI, 44-67) against otitis media, caused by vaccine serotypes. Evidence shows that the vaccine has the potential to prevent pneumonia. Pneumococcal conjugate vaccination has also been shown to reduce nasopharyngeal carriage of vaccine serotypes (particularly serotypes associated with antibiotic resistance). Thus widespread use of pneumococcal conjugate vaccine could substantially reduce the burden of invasive disease and would have the potential to control the global spread of antibiotic resistance in pneumococci. CONCLUSION: It is important that these highly effective vaccines should be made available to children in the developing countries. SN - 0803-5253 UR - https://www.unboundmedicine.com/medline/citation/11430703/Prevention_of_pneumococcal_disease_in_children__Pneumococcal_conjugate_vaccines:_their_use_globally_could_have_a_major_impact_on_public_health_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0803-5253&date=2001&volume=90&issue=5&spage=473 DB - PRIME DP - Unbound Medicine ER -