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The cholesterolaemic effects of dietary fats in cholesteryl ester transfer protein transgenic mice.
Br J Nutr. 2001 Jun; 85(6):643-8.BJ

Abstract

In order to investigate the role of cholesteryl ester transfer protein (CETP) in the cholesterolaemic response to dietary fats, we analysed plasma lipid profiles of CETP-transgenic and control C57BL/6 mice fed standard chow (AIN-93G; AIN), a low-fat diet, and diets high in butter (saturated fatty acids; SFA), high-oleic acid safflower oil (monounsaturated fatty acids; MUFA), and safflower oil (polyunsaturated fatty acids; PUFA) for 5 weeks. Each group contained four or five mice. There were significant diet and dietxgenotype effects on plasma total cholesterol (TC; and respectively), liver TC (and respectively), and esterified cholesterol (EC; and respectively); diet effects on plasma triacylglycerol liver free cholesterol and body weight a genotype effect on body-weight gain and a dietxgenotype effect on energy intake In transgenic mice the SFA diet caused significantly higher plasma TC than the PUFA diet In control mice MUFA and PUFA diets, but not the SFA diet, caused significantly higher plasma TC than the low-fat and AIN diets Transgenic mice fed PUFA had lower plasma TC while transgenic mice fed MUFA had lower LDL+VLDL-cholesterol than controls in the same dietary groups. Transgenic mice fed MUFA and PUFA diets also had significantly higher liver TC and respectively) and EC and respectively) than controls fed the same diets. In the present study we showed that: (1) CETP transgenic mice had a cholesterolaemic response to dietary fats similar to that in human subjects; (2) CETP transgenic mice fed PUFA showed significantly lower plasma TC, while those fed MUFA had lower LDL+VLDL-cholesterol than controls; (3) hepatic accumulation of cholesterol, possibly resulting from the combination of the enhanced cholesteryl ester transfer to apolipoprotein B-containing lipoproteins and increased hepatic uptake of cholesterol, may contribute to the cholesterol-lowering effect of MUFA and PUFA in CETP-transgenic mice; (4) CETP may play a role in appetite and/or energy regulation.

Authors+Show Affiliations

The OSU Nutrition Program, The Ohio State University, Columbus, OH 43210, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11430767

Citation

Chang, C K., and J T. Snook. "The Cholesterolaemic Effects of Dietary Fats in Cholesteryl Ester Transfer Protein Transgenic Mice." The British Journal of Nutrition, vol. 85, no. 6, 2001, pp. 643-8.
Chang CK, Snook JT. The cholesterolaemic effects of dietary fats in cholesteryl ester transfer protein transgenic mice. Br J Nutr. 2001;85(6):643-8.
Chang, C. K., & Snook, J. T. (2001). The cholesterolaemic effects of dietary fats in cholesteryl ester transfer protein transgenic mice. The British Journal of Nutrition, 85(6), 643-8.
Chang CK, Snook JT. The Cholesterolaemic Effects of Dietary Fats in Cholesteryl Ester Transfer Protein Transgenic Mice. Br J Nutr. 2001;85(6):643-8. PubMed PMID: 11430767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cholesterolaemic effects of dietary fats in cholesteryl ester transfer protein transgenic mice. AU - Chang,C K, AU - Snook,J T, PY - 2001/6/30/pubmed PY - 2001/7/13/medline PY - 2001/6/30/entrez SP - 643 EP - 8 JF - The British journal of nutrition JO - Br J Nutr VL - 85 IS - 6 N2 - In order to investigate the role of cholesteryl ester transfer protein (CETP) in the cholesterolaemic response to dietary fats, we analysed plasma lipid profiles of CETP-transgenic and control C57BL/6 mice fed standard chow (AIN-93G; AIN), a low-fat diet, and diets high in butter (saturated fatty acids; SFA), high-oleic acid safflower oil (monounsaturated fatty acids; MUFA), and safflower oil (polyunsaturated fatty acids; PUFA) for 5 weeks. Each group contained four or five mice. There were significant diet and dietxgenotype effects on plasma total cholesterol (TC; and respectively), liver TC (and respectively), and esterified cholesterol (EC; and respectively); diet effects on plasma triacylglycerol liver free cholesterol and body weight a genotype effect on body-weight gain and a dietxgenotype effect on energy intake In transgenic mice the SFA diet caused significantly higher plasma TC than the PUFA diet In control mice MUFA and PUFA diets, but not the SFA diet, caused significantly higher plasma TC than the low-fat and AIN diets Transgenic mice fed PUFA had lower plasma TC while transgenic mice fed MUFA had lower LDL+VLDL-cholesterol than controls in the same dietary groups. Transgenic mice fed MUFA and PUFA diets also had significantly higher liver TC and respectively) and EC and respectively) than controls fed the same diets. In the present study we showed that: (1) CETP transgenic mice had a cholesterolaemic response to dietary fats similar to that in human subjects; (2) CETP transgenic mice fed PUFA showed significantly lower plasma TC, while those fed MUFA had lower LDL+VLDL-cholesterol than controls; (3) hepatic accumulation of cholesterol, possibly resulting from the combination of the enhanced cholesteryl ester transfer to apolipoprotein B-containing lipoproteins and increased hepatic uptake of cholesterol, may contribute to the cholesterol-lowering effect of MUFA and PUFA in CETP-transgenic mice; (4) CETP may play a role in appetite and/or energy regulation. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/11430767/The_cholesterolaemic_effects_of_dietary_fats_in_cholesteryl_ester_transfer_protein_transgenic_mice_ L2 - https://www.cambridge.org/core/product/identifier/S0007114501001143/type/journal_article DB - PRIME DP - Unbound Medicine ER -