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Efficacy of 7-day treatment with metronidazole+miconazole (Neo-Penotran) - a triple-active pessary for the treatment of single and mixed vaginal infections.
Int J Gynaecol Obstet. 2001 Jul; 74(1):35-43.IJ

Abstract

OBJECTIVE

To evaluate the efficacy of Neo-Penotran pessaries (metronidazole 500 mg + miconazole nitrate 100 mg) in candidal, bacterial and trichomonal vaginitis and in mixed vaginal infections.

METHOD

Ninety-seven patients with clinical diagnosis of vaginitis entered this open, non-comparative study. Each patient inserted one pessary twice daily for 7 days. Gynecological and microbiological assessments were carried out before, and 8-10/21-23 days after the start of treatment.

RESULTS

Vaginitis symptoms were resolved in 91% of the 74 patients evaluated, and improved in a further 7%. Microbiological cure rates were 97.3% for trichomonal, 86.6% for bacterial and 81% for candidal vaginitis. Recurrence rates were 2.7, 3.8 and 16.1%, respectively. Overall microbiological cure rate for mixed infections was 86%, with 93% for trichomonal+bacterial, and 73% for bacterial+candidal vaginitis. In two out of three cases with trichomonal+bacterial+candidal infection, the microorganisms were eradicated completely.

CONCLUSION

Neo-Penotran provides immediate and effective treatment for vaginitis, irrespective of single or multiple infection, even when the diagnosis may be uncertain.

Links

Publisher Full Text
linkinghub.elsevier.com
onlinelibrary.wiley.com

Authors+Show Affiliations

Ozyurt E
Onur Medical Research Ltd., Istanbul, Turkey.
Toykuliyeva MB
No affiliation info available
Danilyans IL
No affiliation info available
Morton O
No affiliation info available
Baktir G
No affiliation info available

MeSH

Administration, IntravaginalAdolescentAdultAntifungal AgentsAntitrichomonal AgentsCandidiasis, VulvovaginalDrug Administration ScheduleDrug Therapy, CombinationFemaleHumansMetronidazoleMiconazoleMiddle AgedTreatment OutcomeTrichomonas VaginitisVaginitisVaginosis, Bacterial

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

11430939

Citation

Ozyurt, E, et al. "Efficacy of 7-day Treatment With Metronidazole+miconazole (Neo-Penotran) - a Triple-active Pessary for the Treatment of Single and Mixed Vaginal Infections." International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics, vol. 74, no. 1, 2001, pp. 35-43.
Ozyurt E, Toykuliyeva MB, Danilyans IL, et al. Efficacy of 7-day treatment with metronidazole+miconazole (Neo-Penotran) - a triple-active pessary for the treatment of single and mixed vaginal infections. Int J Gynaecol Obstet. 2001;74(1):35-43.
Ozyurt, E., Toykuliyeva, M. B., Danilyans, I. L., Morton, O., & Baktir, G. (2001). Efficacy of 7-day treatment with metronidazole+miconazole (Neo-Penotran) - a triple-active pessary for the treatment of single and mixed vaginal infections. International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics, 74(1), 35-43.
Ozyurt E, et al. Efficacy of 7-day Treatment With Metronidazole+miconazole (Neo-Penotran) - a Triple-active Pessary for the Treatment of Single and Mixed Vaginal Infections. Int J Gynaecol Obstet. 2001;74(1):35-43. PubMed PMID: 11430939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of 7-day treatment with metronidazole+miconazole (Neo-Penotran) - a triple-active pessary for the treatment of single and mixed vaginal infections. AU - Ozyurt,E, AU - Toykuliyeva,M B, AU - Danilyans,I L, AU - Morton,O, AU - Baktir,G, PY - 2001/6/30/pubmed PY - 2001/9/14/medline PY - 2001/6/30/entrez SP - 35 EP - 43 JF - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JO - Int J Gynaecol Obstet VL - 74 IS - 1 N2 - OBJECTIVE: To evaluate the efficacy of Neo-Penotran pessaries (metronidazole 500 mg + miconazole nitrate 100 mg) in candidal, bacterial and trichomonal vaginitis and in mixed vaginal infections. METHOD: Ninety-seven patients with clinical diagnosis of vaginitis entered this open, non-comparative study. Each patient inserted one pessary twice daily for 7 days. Gynecological and microbiological assessments were carried out before, and 8-10/21-23 days after the start of treatment. RESULTS: Vaginitis symptoms were resolved in 91% of the 74 patients evaluated, and improved in a further 7%. Microbiological cure rates were 97.3% for trichomonal, 86.6% for bacterial and 81% for candidal vaginitis. Recurrence rates were 2.7, 3.8 and 16.1%, respectively. Overall microbiological cure rate for mixed infections was 86%, with 93% for trichomonal+bacterial, and 73% for bacterial+candidal vaginitis. In two out of three cases with trichomonal+bacterial+candidal infection, the microorganisms were eradicated completely. CONCLUSION: Neo-Penotran provides immediate and effective treatment for vaginitis, irrespective of single or multiple infection, even when the diagnosis may be uncertain. SN - 0020-7292 UR - https://www.unboundmedicine.com/medline/citation/11430939/Efficacy_of_7_day_treatment_with_metronidazole+miconazole__Neo_Penotran____a_triple_active_pessary_for_the_treatment_of_single_and_mixed_vaginal_infections_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0020729201003885 DB - PRIME DP - Unbound Medicine ER -