Tags

Type your tag names separated by a space and hit enter

Association of two MTHFR polymorphisms with total homocysteine plasma levels in dialysis patients.
Am J Kidney Dis 2001; 38(1):77-84AJ

Abstract

The effect of the combined 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C-->T and 1298A-->C genotype on total homocysteine (tHcy), folate, and vitamin B(12) plasma levels was investigated in 983 subjects, including 415 hemodialysis patients, 179 peritoneal dialysis patients, and 389 healthy individuals. Mean tHcy plasma concentrations were 27.2 +/- 15.8 micromol/L in hemodialysis patients, 25.4 +/- 19.1 micromol/L in peritoneal dialysis patients, and 8.9 +/- 3.5 micromol/L in healthy individuals. Hyperhomocysteinemia (tHcy > 15 micromol/L) was detected in 81.6% of patients and 2.6% of controls. Multiple stepwise regression analysis showed that the MTHFR 677C-->T/1298A-->C genotype (CC/AA, CC/AC, CC/CC, CT/AA, CT/AC, TT/AA), vitamin use, age, folate and vitamin B(12) plasma level were significant predictors of tHcy plasma levels. Analysis of variance showed that this effect of MTHFR genotypes on tHcy level was caused by significantly greater tHcy levels in 677TT/1298AA hemodialysis and peritoneal dialysis patients versus other genotypes. Compound heterozygous controls (677CT/1298AC genotype) had significantly greater tHcy levels compared with 677CC/1298AA controls. There was no major effect of MTHFR polymorphisms on folate and vitamin B(12) plasma concentrations. This study shows that the MTHFR 677TT/1298AA genotype, but not the 677CT/1298AC genotype, is a significant predictor of tHcy plasma levels in dialysis patients.

Authors+Show Affiliations

Department of Medicine III, Division of Nephrology and Dialysis, University of Vienna, Austria. manuela.foedinger@akh-wien.ac.at

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11431185

Citation

Födinger, M, et al. "Association of Two MTHFR Polymorphisms With Total Homocysteine Plasma Levels in Dialysis Patients." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 38, no. 1, 2001, pp. 77-84.
Födinger M, Buchmayer H, Heinz G, et al. Association of two MTHFR polymorphisms with total homocysteine plasma levels in dialysis patients. Am J Kidney Dis. 2001;38(1):77-84.
Födinger, M., Buchmayer, H., Heinz, G., Papagiannopoulos, M., Kletzmayr, J., Perschl, A., ... Sunder-Plassmann, G. (2001). Association of two MTHFR polymorphisms with total homocysteine plasma levels in dialysis patients. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 38(1), pp. 77-84.
Födinger M, et al. Association of Two MTHFR Polymorphisms With Total Homocysteine Plasma Levels in Dialysis Patients. Am J Kidney Dis. 2001;38(1):77-84. PubMed PMID: 11431185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of two MTHFR polymorphisms with total homocysteine plasma levels in dialysis patients. AU - Födinger,M, AU - Buchmayer,H, AU - Heinz,G, AU - Papagiannopoulos,M, AU - Kletzmayr,J, AU - Perschl,A, AU - Vychytil,A, AU - Hörl,W H, AU - Sunder-Plassmann,G, PY - 2001/6/30/pubmed PY - 2001/9/14/medline PY - 2001/6/30/entrez SP - 77 EP - 84 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am. J. Kidney Dis. VL - 38 IS - 1 N2 - The effect of the combined 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C-->T and 1298A-->C genotype on total homocysteine (tHcy), folate, and vitamin B(12) plasma levels was investigated in 983 subjects, including 415 hemodialysis patients, 179 peritoneal dialysis patients, and 389 healthy individuals. Mean tHcy plasma concentrations were 27.2 +/- 15.8 micromol/L in hemodialysis patients, 25.4 +/- 19.1 micromol/L in peritoneal dialysis patients, and 8.9 +/- 3.5 micromol/L in healthy individuals. Hyperhomocysteinemia (tHcy > 15 micromol/L) was detected in 81.6% of patients and 2.6% of controls. Multiple stepwise regression analysis showed that the MTHFR 677C-->T/1298A-->C genotype (CC/AA, CC/AC, CC/CC, CT/AA, CT/AC, TT/AA), vitamin use, age, folate and vitamin B(12) plasma level were significant predictors of tHcy plasma levels. Analysis of variance showed that this effect of MTHFR genotypes on tHcy level was caused by significantly greater tHcy levels in 677TT/1298AA hemodialysis and peritoneal dialysis patients versus other genotypes. Compound heterozygous controls (677CT/1298AC genotype) had significantly greater tHcy levels compared with 677CC/1298AA controls. There was no major effect of MTHFR polymorphisms on folate and vitamin B(12) plasma concentrations. This study shows that the MTHFR 677TT/1298AA genotype, but not the 677CT/1298AC genotype, is a significant predictor of tHcy plasma levels in dialysis patients. SN - 1523-6838 UR - https://www.unboundmedicine.com/medline/citation/11431185/Association_of_two_MTHFR_polymorphisms_with_total_homocysteine_plasma_levels_in_dialysis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272638601426813 DB - PRIME DP - Unbound Medicine ER -