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A randomized study comparing blood glucose control and risk of severe hypoglycemia achieved by non-programmable versus programmable external insulin pumps.
Diabetes Metab. 2001 Jun; 27(3):323-7.DM

Abstract

OBJECTIVE

To compare a non-programmable and a programmable insulin external pump using regular insulin on glycemic stability, the risk of severe hypoglycemia and metabolic control in type 1 diabetic patients.

MATERIAL AND METHODS

Ten type 1 diabetic patients were involved in a randomized, crossover study comparing two periods of 3 months with continuous subcutaneous insulin infusion (CSII) either with a non-programmable insulin pump or a programmable insulin pump. Comparisons were made among mean blood glucose values before and after meals, at bedtime and at 2: 00 a.m.; the risk of severe hypoglycemia assessed by the low blood glucose index (LBGI); and HbA1c.

RESULTS

Mean average blood glucose (BG) measurements were significantly lower with the programmable in comparison with the non-programmable insulin pump (respectively 157+/-78 vs. 165+/-79, p=0.034). While postprandial values for BG were not different between the two pumps, the use of the programmable pump resulted in a significant decrease in mean preprandial BG levels (140+/-68 vs. 150+/-73 mg/dl p=0.039). Conversely mean BG level was lower at 2 a.m. with the non-prgrammable pump (125+/-81 vs. 134 +/-93 mg/dl, p=0.02) but with a higher incidence of hypoglycemia. Mean LBGI was comparable with the two pumps (3.1+/-8.6 vs. 2.8+/-6.9, p=0.1). There was a 0.2% decrease in HbA1c during the programmable pump period that did not reach statistical significance (p=0.37).

CONCLUSIONS

The present study suggests that programmable external insulin pumps, although more complex and more expensive than non-programmable insulin pumps, significantly reduce fasting glycemia during the day without increasing the risk of severe hypoglycemia and are safer during the night.

Authors+Show Affiliations

Catargi B
University Hospital of Bordeaux, Hôpital Haut-Lévêque, 33604 Pessac, France. bogdan.catargi@ph.u-bordeaux2.fr
Breilh D
No affiliation info available
Gin H
No affiliation info available
Rigalleau V
No affiliation info available
Saux MC
No affiliation info available
Roger P
No affiliation info available
Tabarin A
No affiliation info available

MeSH

AdultBlood GlucoseDiabetes Mellitus, Type 1Equipment DesignFemaleHumansHypoglycemiaInfusion Pumps, ImplantableInsulin Infusion SystemsMaleRisk Factors

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11431597

Citation

Catargi, B, et al. "A Randomized Study Comparing Blood Glucose Control and Risk of Severe Hypoglycemia Achieved By Non-programmable Versus Programmable External Insulin Pumps." Diabetes & Metabolism, vol. 27, no. 3, 2001, pp. 323-7.
Catargi B, Breilh D, Gin H, et al. A randomized study comparing blood glucose control and risk of severe hypoglycemia achieved by non-programmable versus programmable external insulin pumps. Diabetes Metab. 2001;27(3):323-7.
Catargi, B., Breilh, D., Gin, H., Rigalleau, V., Saux, M. C., Roger, P., & Tabarin, A. (2001). A randomized study comparing blood glucose control and risk of severe hypoglycemia achieved by non-programmable versus programmable external insulin pumps. Diabetes & Metabolism, 27(3), 323-7.
Catargi B, et al. A Randomized Study Comparing Blood Glucose Control and Risk of Severe Hypoglycemia Achieved By Non-programmable Versus Programmable External Insulin Pumps. Diabetes Metab. 2001;27(3):323-7. PubMed PMID: 11431597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized study comparing blood glucose control and risk of severe hypoglycemia achieved by non-programmable versus programmable external insulin pumps. AU - Catargi,B, AU - Breilh,D, AU - Gin,H, AU - Rigalleau,V, AU - Saux,M C, AU - Roger,P, AU - Tabarin,A, PY - 2001/6/30/pubmed PY - 2001/9/21/medline PY - 2001/6/30/entrez SP - 323 EP - 7 JF - Diabetes & metabolism JO - Diabetes Metab VL - 27 IS - 3 N2 - OBJECTIVE: To compare a non-programmable and a programmable insulin external pump using regular insulin on glycemic stability, the risk of severe hypoglycemia and metabolic control in type 1 diabetic patients. MATERIAL AND METHODS: Ten type 1 diabetic patients were involved in a randomized, crossover study comparing two periods of 3 months with continuous subcutaneous insulin infusion (CSII) either with a non-programmable insulin pump or a programmable insulin pump. Comparisons were made among mean blood glucose values before and after meals, at bedtime and at 2: 00 a.m.; the risk of severe hypoglycemia assessed by the low blood glucose index (LBGI); and HbA1c. RESULTS: Mean average blood glucose (BG) measurements were significantly lower with the programmable in comparison with the non-programmable insulin pump (respectively 157+/-78 vs. 165+/-79, p=0.034). While postprandial values for BG were not different between the two pumps, the use of the programmable pump resulted in a significant decrease in mean preprandial BG levels (140+/-68 vs. 150+/-73 mg/dl p=0.039). Conversely mean BG level was lower at 2 a.m. with the non-prgrammable pump (125+/-81 vs. 134 +/-93 mg/dl, p=0.02) but with a higher incidence of hypoglycemia. Mean LBGI was comparable with the two pumps (3.1+/-8.6 vs. 2.8+/-6.9, p=0.1). There was a 0.2% decrease in HbA1c during the programmable pump period that did not reach statistical significance (p=0.37). CONCLUSIONS: The present study suggests that programmable external insulin pumps, although more complex and more expensive than non-programmable insulin pumps, significantly reduce fasting glycemia during the day without increasing the risk of severe hypoglycemia and are safer during the night. SN - 1262-3636 UR - https://www.unboundmedicine.com/medline/citation/11431597/A_randomized_study_comparing_blood_glucose_control_and_risk_of_severe_hypoglycemia_achieved_by_non_programmable_versus_programmable_external_insulin_pumps_ L2 - https://www.diseaseinfosearch.org/result/9680 DB - PRIME DP - Unbound Medicine ER -
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