Tags

Type your tag names separated by a space and hit enter

Calcium, dairy products, and the risk of prostate cancer.
Prostate. 2001 Jul 01; 48(2):118-21.P

Abstract

BACKGROUND

Calcium intake has been suggested to play a role in the etiology of prostate cancer, since it is inversely related to vitamin D levels, which, in turn, would have an antiproliferative effect on human cancer cell lines. The hypothesis that high calcium and low vitamin D levels are associated with prostate cancer risk, however, remains unconvincingly demonstrated.

METHODS

This relation was investigated in a case-control study of prostate cancer conducted in Northern Italy between 1985 and 1992 on 288 cases and 762 controls admitted to hospital for acute non-neoplastic diseases.

RESULTS

No significant relation was found for calcium intake: compared to the lowest quintile of intake, the multivariate odds ratios (OR) of prostatic cancer, after adjusting for age, study center, education, body mass index, and meat intake, for increasing intake quintiles were 1.21, 0.68, 0.64, 1.12, with no trend in risk. The OR was 0.99 for an increment of 500 mg per day of calcium. The risk estimates were consistent in two strata of age (< 65 and > or = 65 years at diagnosis).

CONCLUSIONS

Our results do not support an association between calcium and the risk of prostate cancer. However, the present study cannot address the effect of calcium in the ranges where an increased risk of prostate cancer has been noted previously, and with specific reference to advanced disease.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy. tavani@marionegri.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11433421

Citation

Tavani, A, et al. "Calcium, Dairy Products, and the Risk of Prostate Cancer." The Prostate, vol. 48, no. 2, 2001, pp. 118-21.
Tavani A, Gallus S, Franceschi S, et al. Calcium, dairy products, and the risk of prostate cancer. Prostate. 2001;48(2):118-21.
Tavani, A., Gallus, S., Franceschi, S., & La Vecchia, C. (2001). Calcium, dairy products, and the risk of prostate cancer. The Prostate, 48(2), 118-21.
Tavani A, et al. Calcium, Dairy Products, and the Risk of Prostate Cancer. Prostate. 2001 Jul 1;48(2):118-21. PubMed PMID: 11433421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcium, dairy products, and the risk of prostate cancer. AU - Tavani,A, AU - Gallus,S, AU - Franceschi,S, AU - La Vecchia,C, PY - 2001/7/4/pubmed PY - 2001/7/28/medline PY - 2001/7/4/entrez SP - 118 EP - 21 JF - The Prostate JO - Prostate VL - 48 IS - 2 N2 - BACKGROUND: Calcium intake has been suggested to play a role in the etiology of prostate cancer, since it is inversely related to vitamin D levels, which, in turn, would have an antiproliferative effect on human cancer cell lines. The hypothesis that high calcium and low vitamin D levels are associated with prostate cancer risk, however, remains unconvincingly demonstrated. METHODS: This relation was investigated in a case-control study of prostate cancer conducted in Northern Italy between 1985 and 1992 on 288 cases and 762 controls admitted to hospital for acute non-neoplastic diseases. RESULTS: No significant relation was found for calcium intake: compared to the lowest quintile of intake, the multivariate odds ratios (OR) of prostatic cancer, after adjusting for age, study center, education, body mass index, and meat intake, for increasing intake quintiles were 1.21, 0.68, 0.64, 1.12, with no trend in risk. The OR was 0.99 for an increment of 500 mg per day of calcium. The risk estimates were consistent in two strata of age (< 65 and > or = 65 years at diagnosis). CONCLUSIONS: Our results do not support an association between calcium and the risk of prostate cancer. However, the present study cannot address the effect of calcium in the ranges where an increased risk of prostate cancer has been noted previously, and with specific reference to advanced disease. SN - 0270-4137 UR - https://www.unboundmedicine.com/medline/citation/11433421/Calcium_dairy_products_and_the_risk_of_prostate_cancer_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0270-4137&amp;date=2001&amp;volume=48&amp;issue=2&amp;spage=118 DB - PRIME DP - Unbound Medicine ER -