Tags

Type your tag names separated by a space and hit enter

Linkage analysis in multiple sclerosis of chromosomal regions syntenic to experimental autoimmune disease loci.
Eur J Hum Genet. 2001 Jun; 9(6):458-63.EJ

Abstract

Multiple sclerosis is a demyelinating disorder of the central nervous system with a putative autoimmune aetiology in which several genes are thought to be involved. Four published genomic screens have confirmed that a gene influencing MS resides within or close to the HLA class II region in 6p21. Still, this locus is likely to confer only a part of the genetic susceptibility in MS. Further, all four studies identified a number of other regions with possible linkage. We have investigated eight chromosomal intervals syntenic to loci of importance for experimental autoimmune model diseases in the rat in 74 Swedish MS families. Possible linkage (a non-parametric linkage NPL score of 1.16 by GENEHUNTER computer package) was observed with markers in 12p13.3, a region syntenic to the rat Oia2 locus which is importance for oil induced arthritis (OIA). Four markers in the T cell receptor beta chain gene region in 7q35 showed possible linkage (highest NPL score of 1.16). This locus is syntenic to the rat Cia3 locus (collagen induced arthritis). These two loci at least partially overlap with chromosomal regions showing indicative evidence for linkage in the previous MS genomic screens. Indeed, both Oia2 and Cia3 were recently found to be linked also with experimental autoimmune encephalomyelitis, a commonly used model for MS. Markers in 2p12, 3p25, 10q11.23, 17q21-25, 19q13.1, and 22q12-13 failed to provide evidence for linkage. We conclude that evidence is amounting that 12p13-12 and 7q34-36 may harbour genes with an importance for MS. The synteny with experimental loci may eventually facilitate their identification.

Authors+Show Affiliations

Division of Neurology, Karolinska Institute at Huddinge University Hospital, S-14186 Huddinge, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11436128

Citation

Xu, C, et al. "Linkage Analysis in Multiple Sclerosis of Chromosomal Regions Syntenic to Experimental Autoimmune Disease Loci." European Journal of Human Genetics : EJHG, vol. 9, no. 6, 2001, pp. 458-63.
Xu C, Dai Y, Lorentzen JC, et al. Linkage analysis in multiple sclerosis of chromosomal regions syntenic to experimental autoimmune disease loci. Eur J Hum Genet. 2001;9(6):458-63.
Xu, C., Dai, Y., Lorentzen, J. C., Dahlman, I., Olsson, T., & Hillert, J. (2001). Linkage analysis in multiple sclerosis of chromosomal regions syntenic to experimental autoimmune disease loci. European Journal of Human Genetics : EJHG, 9(6), 458-63.
Xu C, et al. Linkage Analysis in Multiple Sclerosis of Chromosomal Regions Syntenic to Experimental Autoimmune Disease Loci. Eur J Hum Genet. 2001;9(6):458-63. PubMed PMID: 11436128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Linkage analysis in multiple sclerosis of chromosomal regions syntenic to experimental autoimmune disease loci. AU - Xu,C, AU - Dai,Y, AU - Lorentzen,J C, AU - Dahlman,I, AU - Olsson,T, AU - Hillert,J, PY - 2000/12/01/received PY - 2001/03/08/revised PY - 2001/03/14/accepted PY - 2001/7/4/pubmed PY - 2001/10/12/medline PY - 2001/7/4/entrez SP - 458 EP - 63 JF - European journal of human genetics : EJHG JO - Eur. J. Hum. Genet. VL - 9 IS - 6 N2 - Multiple sclerosis is a demyelinating disorder of the central nervous system with a putative autoimmune aetiology in which several genes are thought to be involved. Four published genomic screens have confirmed that a gene influencing MS resides within or close to the HLA class II region in 6p21. Still, this locus is likely to confer only a part of the genetic susceptibility in MS. Further, all four studies identified a number of other regions with possible linkage. We have investigated eight chromosomal intervals syntenic to loci of importance for experimental autoimmune model diseases in the rat in 74 Swedish MS families. Possible linkage (a non-parametric linkage NPL score of 1.16 by GENEHUNTER computer package) was observed with markers in 12p13.3, a region syntenic to the rat Oia2 locus which is importance for oil induced arthritis (OIA). Four markers in the T cell receptor beta chain gene region in 7q35 showed possible linkage (highest NPL score of 1.16). This locus is syntenic to the rat Cia3 locus (collagen induced arthritis). These two loci at least partially overlap with chromosomal regions showing indicative evidence for linkage in the previous MS genomic screens. Indeed, both Oia2 and Cia3 were recently found to be linked also with experimental autoimmune encephalomyelitis, a commonly used model for MS. Markers in 2p12, 3p25, 10q11.23, 17q21-25, 19q13.1, and 22q12-13 failed to provide evidence for linkage. We conclude that evidence is amounting that 12p13-12 and 7q34-36 may harbour genes with an importance for MS. The synteny with experimental loci may eventually facilitate their identification. SN - 1018-4813 UR - https://www.unboundmedicine.com/medline/citation/11436128/Linkage_analysis_in_multiple_sclerosis_of_chromosomal_regions_syntenic_to_experimental_autoimmune_disease_loci_ L2 - http://dx.doi.org/10.1038/sj.ejhg.5200653 DB - PRIME DP - Unbound Medicine ER -