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Environmental risk factors and Parkinson's disease: a metaanalysis.
Environ Res 2001; 86(2):122-7ER

Abstract

The study aim was to examine the association between Parkinson's disease (PD) and exposure to environmental factors such as living in a rural area, well water use, farming, exposure to farm animals, or living on a farm, and pesticides. A series of metaanalyses of peer-reviewed studies were performed, using 16 studies for living in rural area, 18 studies for well water drinking, 11 studies for farming, and 14 studies for pesticides. Prior to the metaanalyses, all studies were reviewed and evaluated for heterogeneity and publication bias. Significant heterogeneity among studies was detected and combined odds ratio (OR) was calculated using the random and the fixed-effect models. The majority of the studies reported consistent elevation in the risk of PD with exposure to environmental factors such as rural living and farming. The combined OR for rural residence was 1.56 [95% confidence interval (95% CI) 1.18-2.07] for all the studies, and 2.17(95% CI 1.54-3.06) for studies performed in United States. The combined OR for well water use was 1.26 (95% CI 0.97-1.64) for all the studies, and 1.44(95% CI 0.92-2.24) for studies done in United States. The combined OR for farming, exposure to farm animals, or living on a farm was 1.42 (95% CI 1.05-1.91) for all studies, and 1.72(95% CI 1.20-2.46) for studies done in United States. The combined OR for pesticides exposure was 1.85(95% CI 1.31-2.60) for all studies, and 2.16(95% CI 1.95-2.39) for studies done in United States. Dose-response relationships could not be established due to the imprecise nature of the reported data. Our findings suggest that living in a rural area, drinking well water, farming, and exposure to pesticides may be a risk factor for developing PD.

Authors+Show Affiliations

Department of Public Health, Medical College of Ohio, Toledo, Ohio 43614-5809, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

11437458

Citation

Priyadarshi, A, et al. "Environmental Risk Factors and Parkinson's Disease: a Metaanalysis." Environmental Research, vol. 86, no. 2, 2001, pp. 122-7.
Priyadarshi A, Khuder SA, Schaub EA, et al. Environmental risk factors and Parkinson's disease: a metaanalysis. Environ Res. 2001;86(2):122-7.
Priyadarshi, A., Khuder, S. A., Schaub, E. A., & Priyadarshi, S. S. (2001). Environmental risk factors and Parkinson's disease: a metaanalysis. Environmental Research, 86(2), pp. 122-7.
Priyadarshi A, et al. Environmental Risk Factors and Parkinson's Disease: a Metaanalysis. Environ Res. 2001;86(2):122-7. PubMed PMID: 11437458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Environmental risk factors and Parkinson's disease: a metaanalysis. AU - Priyadarshi,A, AU - Khuder,S A, AU - Schaub,E A, AU - Priyadarshi,S S, PY - 2001/7/5/pubmed PY - 2001/8/10/medline PY - 2001/7/5/entrez SP - 122 EP - 7 JF - Environmental research JO - Environ. Res. VL - 86 IS - 2 N2 - The study aim was to examine the association between Parkinson's disease (PD) and exposure to environmental factors such as living in a rural area, well water use, farming, exposure to farm animals, or living on a farm, and pesticides. A series of metaanalyses of peer-reviewed studies were performed, using 16 studies for living in rural area, 18 studies for well water drinking, 11 studies for farming, and 14 studies for pesticides. Prior to the metaanalyses, all studies were reviewed and evaluated for heterogeneity and publication bias. Significant heterogeneity among studies was detected and combined odds ratio (OR) was calculated using the random and the fixed-effect models. The majority of the studies reported consistent elevation in the risk of PD with exposure to environmental factors such as rural living and farming. The combined OR for rural residence was 1.56 [95% confidence interval (95% CI) 1.18-2.07] for all the studies, and 2.17(95% CI 1.54-3.06) for studies performed in United States. The combined OR for well water use was 1.26 (95% CI 0.97-1.64) for all the studies, and 1.44(95% CI 0.92-2.24) for studies done in United States. The combined OR for farming, exposure to farm animals, or living on a farm was 1.42 (95% CI 1.05-1.91) for all studies, and 1.72(95% CI 1.20-2.46) for studies done in United States. The combined OR for pesticides exposure was 1.85(95% CI 1.31-2.60) for all studies, and 2.16(95% CI 1.95-2.39) for studies done in United States. Dose-response relationships could not be established due to the imprecise nature of the reported data. Our findings suggest that living in a rural area, drinking well water, farming, and exposure to pesticides may be a risk factor for developing PD. SN - 0013-9351 UR - https://www.unboundmedicine.com/medline/citation/11437458/Environmental_risk_factors_and_Parkinson's_disease:_a_metaanalysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(01)94264-1 DB - PRIME DP - Unbound Medicine ER -