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Spinal cord pilocytic astrocytoma with cranial meningeal metastases.
J Clin Neurosci. 2001 Jul; 8(4):374-7.JC

Abstract

Dissemination of tumour cells along the cerebrospinal fluid (CSF) pathway has been reported mostly in medulloblastomas, germ cell tumours or high grade gliomas. Juvenile pilocytic astrocytoma (JPA) is usually a benign astrocytoma. However, drop metastases of indolent nature from intracranial tumours to the spinal cord are documented. All of the previously reported cases represent metastases of cerebellar or hypothalamic tumours spreading to the spinal cord. We document in this paper the first report of a spinal cord pilocytic astrocytoma spreading via the CSF to the cerebral meninges. A 9 year old girl had a JPA of C5 to C7 subtotally resected. Two and a half years later she presented with hydrocephalus with radiologically meningeal enhancement. The meninges were biopsied which showed metastatic JPA. The girl was relatively well 4 years after initial surgery with residual tumour. Spinal cord JPA can rarely metastasize to the cranial meninges. Similar to intracranial tumours which spread to the spinal cord, such metastatic lesions are indolent.

Authors+Show Affiliations

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, P.R. China. hkng@cuhk.edu.hkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

11437586

Citation

Ng, H K., et al. "Spinal Cord Pilocytic Astrocytoma With Cranial Meningeal Metastases." Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, vol. 8, no. 4, 2001, pp. 374-7.
Ng HK, Leung CH, Boet R, et al. Spinal cord pilocytic astrocytoma with cranial meningeal metastases. J Clin Neurosci. 2001;8(4):374-7.
Ng, H. K., Leung, C. H., Boet, R., & Poon, W. S. (2001). Spinal cord pilocytic astrocytoma with cranial meningeal metastases. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 8(4), 374-7.
Ng HK, et al. Spinal Cord Pilocytic Astrocytoma With Cranial Meningeal Metastases. J Clin Neurosci. 2001;8(4):374-7. PubMed PMID: 11437586.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spinal cord pilocytic astrocytoma with cranial meningeal metastases. AU - Ng,H K, AU - Leung,C H, AU - Boet,R, AU - Poon,W S, PY - 2001/7/5/pubmed PY - 2001/9/28/medline PY - 2001/7/5/entrez SP - 374 EP - 7 JF - Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia JO - J Clin Neurosci VL - 8 IS - 4 N2 - Dissemination of tumour cells along the cerebrospinal fluid (CSF) pathway has been reported mostly in medulloblastomas, germ cell tumours or high grade gliomas. Juvenile pilocytic astrocytoma (JPA) is usually a benign astrocytoma. However, drop metastases of indolent nature from intracranial tumours to the spinal cord are documented. All of the previously reported cases represent metastases of cerebellar or hypothalamic tumours spreading to the spinal cord. We document in this paper the first report of a spinal cord pilocytic astrocytoma spreading via the CSF to the cerebral meninges. A 9 year old girl had a JPA of C5 to C7 subtotally resected. Two and a half years later she presented with hydrocephalus with radiologically meningeal enhancement. The meninges were biopsied which showed metastatic JPA. The girl was relatively well 4 years after initial surgery with residual tumour. Spinal cord JPA can rarely metastasize to the cranial meninges. Similar to intracranial tumours which spread to the spinal cord, such metastatic lesions are indolent. SN - 0967-5868 UR - https://www.unboundmedicine.com/medline/citation/11437586/Spinal_cord_pilocytic_astrocytoma_with_cranial_meningeal_metastases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0967-5868(00)90762-8 DB - PRIME DP - Unbound Medicine ER -