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Effect of anionic polymers on the release of propranolol hydrochloride from matrix tablets.
Eur J Pharm Biopharm. 2001 Jul; 52(1):75-82.EJ

Abstract

Anionic polymers, namely Eudragit S, Eudragit L 100-55, and sodium carboxymethylcellulose, were incorporated into hydroxypropylmethylcellulose (HPMC K100M) to modify the drug release from HPMC matrices. The effects of changing the ratio of HPMC to anionic polymers were examined in water and in media with different pH. The dissolution profiles were compared according to release rates. The interaction between propranolol hydrochloride and anionic polymers was confirmed using the UV difference spectra method. The drug release was controlled with the type of anionic polymer and the interaction between propranolol hydrochloride and anionic polymers. The HPMC-anionic polymer ratio also influenced the drug release. The matrix containing HPMC-Eudragit L 100-55 (1:1 ratio) produced pH-independent extended-release tablets in water, 0.1 N HCl, and pH 6.8 phosphate buffer.

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Authors+Show Affiliations

Takka S
Industrial Pharmacy Program, College of Pharmacy, University of Cincinnati, Cincinnati, OH, USA. sevgitakka@turk.net
Rajbhandari S
No affiliation info available
Sakr A
No affiliation info available

MeSH

Acrylic ResinsCarboxymethylcellulose SodiumHydrogen-Ion ConcentrationLactoseMethylcelluloseOxazinesPolymethacrylic AcidsPropranololSolubilitySpectrophotometry, UltravioletTablets

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11438426

Citation

Takka, S, et al. "Effect of Anionic Polymers On the Release of Propranolol Hydrochloride From Matrix Tablets." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 52, no. 1, 2001, pp. 75-82.
Takka S, Rajbhandari S, Sakr A. Effect of anionic polymers on the release of propranolol hydrochloride from matrix tablets. Eur J Pharm Biopharm. 2001;52(1):75-82.
Takka, S., Rajbhandari, S., & Sakr, A. (2001). Effect of anionic polymers on the release of propranolol hydrochloride from matrix tablets. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 52(1), 75-82.
Takka S, Rajbhandari S, Sakr A. Effect of Anionic Polymers On the Release of Propranolol Hydrochloride From Matrix Tablets. Eur J Pharm Biopharm. 2001;52(1):75-82. PubMed PMID: 11438426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of anionic polymers on the release of propranolol hydrochloride from matrix tablets. AU - Takka,S, AU - Rajbhandari,S, AU - Sakr,A, PY - 2001/7/5/pubmed PY - 2001/9/8/medline PY - 2001/7/5/entrez SP - 75 EP - 82 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 52 IS - 1 N2 - Anionic polymers, namely Eudragit S, Eudragit L 100-55, and sodium carboxymethylcellulose, were incorporated into hydroxypropylmethylcellulose (HPMC K100M) to modify the drug release from HPMC matrices. The effects of changing the ratio of HPMC to anionic polymers were examined in water and in media with different pH. The dissolution profiles were compared according to release rates. The interaction between propranolol hydrochloride and anionic polymers was confirmed using the UV difference spectra method. The drug release was controlled with the type of anionic polymer and the interaction between propranolol hydrochloride and anionic polymers. The HPMC-anionic polymer ratio also influenced the drug release. The matrix containing HPMC-Eudragit L 100-55 (1:1 ratio) produced pH-independent extended-release tablets in water, 0.1 N HCl, and pH 6.8 phosphate buffer. SN - 0939-6411 UR - https://www.unboundmedicine.com/medline/citation/11438426/Effect_of_anionic_polymers_on_the_release_of_propranolol_hydrochloride_from_matrix_tablets_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939641101001473 DB - PRIME DP - Unbound Medicine ER -