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Similarity in expression of cell cycle proteins between in situ and invasive ductal breast lesions of same differentiation grade.
J Pathol. 2001 Jul; 194(3):327-33.JP

Abstract

There is increasing evidence that there are different progression routes leading to invasive breast cancer, depending on histology and differentiation grade. The aim of this study was to determine alterations in the expression of proteins involved in proliferation and apoptosis in non-invasive and invasive ductal breast lesions. Immunohistochemistry was performed on 106 usual ductal hyperplasias (UDH), 61 DCIS lesions and 53 invasive ductal breast carcinomas. Increased proliferation (Ki67), overexpression of cyclin D1, HER-2/neu, p21 and p53, and decreased expression of bcl-2 and p27 could already be found in UDH. Significant differences between UDH and DCIS lesions were found for only one protein when UDH was compared with well-differentiated DCIS (p27), for three proteins when compared with intermediately differentiated DCIS (p21, cyclin D1, Ki-67), and for all proteins when compared with poorly-differentiated DCIS. Comparing DCIS with invasive lesions of same differentiation grade, proliferation was elevated in the invasive lesions. Altered expression of the other proteins was in general only slightly increased in the invasive lesion compared with DCIS. The number of proteins with altered expression per lesion was highest in poorly-differentiated lesions and was comparable between DCIS and invasive cancer of the same differentiation grade. In conclusion, the biggest changes in expression of these proliferation and apoptosis related proteins appear to occur during the transition from hyperplasia to DCIS; they probably play a minor role in the transition from DCIS to invasive breast lesion of same differentiation grade. Well-differentiated in situ and invasive breast lesions share many of the aberrations in expression of these proteins, as do poorly-differentiated in situ and invasive lesions. However, there are many differences between the well and poorly-differentiated lesions. This further supports the existence of different progression routes leading to breast cancer.

Authors+Show Affiliations

Department of Pathology, Free University Hospital, Amsterdam, the Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11439365

Citation

Mommers, E C., et al. "Similarity in Expression of Cell Cycle Proteins Between in Situ and Invasive Ductal Breast Lesions of Same Differentiation Grade." The Journal of Pathology, vol. 194, no. 3, 2001, pp. 327-33.
Mommers EC, Leonhart AM, Falix F, et al. Similarity in expression of cell cycle proteins between in situ and invasive ductal breast lesions of same differentiation grade. J Pathol. 2001;194(3):327-33.
Mommers, E. C., Leonhart, A. M., Falix, F., Michalides, R., Meijer, C. J., Baak, J. P., & Diest, P. J. (2001). Similarity in expression of cell cycle proteins between in situ and invasive ductal breast lesions of same differentiation grade. The Journal of Pathology, 194(3), 327-33.
Mommers EC, et al. Similarity in Expression of Cell Cycle Proteins Between in Situ and Invasive Ductal Breast Lesions of Same Differentiation Grade. J Pathol. 2001;194(3):327-33. PubMed PMID: 11439365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Similarity in expression of cell cycle proteins between in situ and invasive ductal breast lesions of same differentiation grade. AU - Mommers,E C, AU - Leonhart,A M, AU - Falix,F, AU - Michalides,R, AU - Meijer,C J, AU - Baak,J P, AU - Diest,P J, PY - 2001/7/6/pubmed PY - 2001/8/10/medline PY - 2001/7/6/entrez SP - 327 EP - 33 JF - The Journal of pathology JO - J Pathol VL - 194 IS - 3 N2 - There is increasing evidence that there are different progression routes leading to invasive breast cancer, depending on histology and differentiation grade. The aim of this study was to determine alterations in the expression of proteins involved in proliferation and apoptosis in non-invasive and invasive ductal breast lesions. Immunohistochemistry was performed on 106 usual ductal hyperplasias (UDH), 61 DCIS lesions and 53 invasive ductal breast carcinomas. Increased proliferation (Ki67), overexpression of cyclin D1, HER-2/neu, p21 and p53, and decreased expression of bcl-2 and p27 could already be found in UDH. Significant differences between UDH and DCIS lesions were found for only one protein when UDH was compared with well-differentiated DCIS (p27), for three proteins when compared with intermediately differentiated DCIS (p21, cyclin D1, Ki-67), and for all proteins when compared with poorly-differentiated DCIS. Comparing DCIS with invasive lesions of same differentiation grade, proliferation was elevated in the invasive lesions. Altered expression of the other proteins was in general only slightly increased in the invasive lesion compared with DCIS. The number of proteins with altered expression per lesion was highest in poorly-differentiated lesions and was comparable between DCIS and invasive cancer of the same differentiation grade. In conclusion, the biggest changes in expression of these proliferation and apoptosis related proteins appear to occur during the transition from hyperplasia to DCIS; they probably play a minor role in the transition from DCIS to invasive breast lesion of same differentiation grade. Well-differentiated in situ and invasive breast lesions share many of the aberrations in expression of these proteins, as do poorly-differentiated in situ and invasive lesions. However, there are many differences between the well and poorly-differentiated lesions. This further supports the existence of different progression routes leading to breast cancer. SN - 0022-3417 UR - https://www.unboundmedicine.com/medline/citation/11439365/Similarity_in_expression_of_cell_cycle_proteins_between_in_situ_and_invasive_ductal_breast_lesions_of_same_differentiation_grade_ L2 - https://doi.org/10.1002/path.910 DB - PRIME DP - Unbound Medicine ER -