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Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice.

Abstract

The mechanisms responsible for the antidiabetic activity of both the white ginseng radix (Ginseng Radix Alba, GRA) and the rootlet (Ginseng Radix Palva, GRP) were investigated. After a four week oral administration, the fasting blood glucose levels in the GRA- and GRP-treated groups were lower when compared to the control group. To elucidate the hypoglycemic mechanism(s) of the ginseng radices, glucose absorption from the small intestine, hepatic hexokinase and glucose-6-phosphatase activities, in addition to PPAR-gamma expression in adipose tissue were examined. The results strongly suggest that GRA can improve hyperglycemia in KKAy mice, possibly by blocking intestinal glucose absorption and inhibiting hepatic glucose-6-phosphatase, and GRP through the upregulation of adipocytic PPAR-y protein expression as well as inhibiting intestinal glucose absorption.

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  • Authors+Show Affiliations

    ,

    Kyung Hee University, School of Pharmacy, Seoul, Korea. suchung@khu.ac.kr

    ,

    Source

    Archives of pharmacal research 24:3 2001 Jun pg 214-8

    MeSH

    Animals
    Blood Glucose
    Blotting, Western
    Diabetes Mellitus
    Hypoglycemic Agents
    Insulin
    Intestinal Absorption
    Liver
    Male
    Mice
    Mice, Inbred Strains
    Panax
    Phytotherapy
    Plant Extracts
    Plant Roots
    Receptors, Cytoplasmic and Nuclear
    Transcription Factors

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11440080

    Citation

    Chung, S H., et al. "Comparisons Between White Ginseng Radix and Rootlet for Antidiabetic Activity and Mechanism in KKAy Mice." Archives of Pharmacal Research, vol. 24, no. 3, 2001, pp. 214-8.
    Chung SH, Choi CG, Park SH. Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice. Arch Pharm Res. 2001;24(3):214-8.
    Chung, S. H., Choi, C. G., & Park, S. H. (2001). Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice. Archives of Pharmacal Research, 24(3), pp. 214-8.
    Chung SH, Choi CG, Park SH. Comparisons Between White Ginseng Radix and Rootlet for Antidiabetic Activity and Mechanism in KKAy Mice. Arch Pharm Res. 2001;24(3):214-8. PubMed PMID: 11440080.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice. AU - Chung,S H, AU - Choi,C G, AU - Park,S H, PY - 2001/7/7/pubmed PY - 2002/1/5/medline PY - 2001/7/7/entrez SP - 214 EP - 8 JF - Archives of pharmacal research JO - Arch. Pharm. Res. VL - 24 IS - 3 N2 - The mechanisms responsible for the antidiabetic activity of both the white ginseng radix (Ginseng Radix Alba, GRA) and the rootlet (Ginseng Radix Palva, GRP) were investigated. After a four week oral administration, the fasting blood glucose levels in the GRA- and GRP-treated groups were lower when compared to the control group. To elucidate the hypoglycemic mechanism(s) of the ginseng radices, glucose absorption from the small intestine, hepatic hexokinase and glucose-6-phosphatase activities, in addition to PPAR-gamma expression in adipose tissue were examined. The results strongly suggest that GRA can improve hyperglycemia in KKAy mice, possibly by blocking intestinal glucose absorption and inhibiting hepatic glucose-6-phosphatase, and GRP through the upregulation of adipocytic PPAR-y protein expression as well as inhibiting intestinal glucose absorption. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/11440080/Comparisons_between_white_ginseng_radix_and_rootlet_for_antidiabetic_activity_and_mechanism_in_KKAy_mice_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11440080.ui DB - PRIME DP - Unbound Medicine ER -