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Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice.
Arch Pharm Res 2001; 24(3):214-8AP

Abstract

The mechanisms responsible for the antidiabetic activity of both the white ginseng radix (Ginseng Radix Alba, GRA) and the rootlet (Ginseng Radix Palva, GRP) were investigated. After a four week oral administration, the fasting blood glucose levels in the GRA- and GRP-treated groups were lower when compared to the control group. To elucidate the hypoglycemic mechanism(s) of the ginseng radices, glucose absorption from the small intestine, hepatic hexokinase and glucose-6-phosphatase activities, in addition to PPAR-gamma expression in adipose tissue were examined. The results strongly suggest that GRA can improve hyperglycemia in KKAy mice, possibly by blocking intestinal glucose absorption and inhibiting hepatic glucose-6-phosphatase, and GRP through the upregulation of adipocytic PPAR-y protein expression as well as inhibiting intestinal glucose absorption.

Authors+Show Affiliations

Kyung Hee University, School of Pharmacy, Seoul, Korea. suchung@khu.ac.krNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11440080

Citation

Chung, S H., et al. "Comparisons Between White Ginseng Radix and Rootlet for Antidiabetic Activity and Mechanism in KKAy Mice." Archives of Pharmacal Research, vol. 24, no. 3, 2001, pp. 214-8.
Chung SH, Choi CG, Park SH. Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice. Arch Pharm Res. 2001;24(3):214-8.
Chung, S. H., Choi, C. G., & Park, S. H. (2001). Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice. Archives of Pharmacal Research, 24(3), pp. 214-8.
Chung SH, Choi CG, Park SH. Comparisons Between White Ginseng Radix and Rootlet for Antidiabetic Activity and Mechanism in KKAy Mice. Arch Pharm Res. 2001;24(3):214-8. PubMed PMID: 11440080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice. AU - Chung,S H, AU - Choi,C G, AU - Park,S H, PY - 2001/7/7/pubmed PY - 2002/1/5/medline PY - 2001/7/7/entrez SP - 214 EP - 8 JF - Archives of pharmacal research JO - Arch. Pharm. Res. VL - 24 IS - 3 N2 - The mechanisms responsible for the antidiabetic activity of both the white ginseng radix (Ginseng Radix Alba, GRA) and the rootlet (Ginseng Radix Palva, GRP) were investigated. After a four week oral administration, the fasting blood glucose levels in the GRA- and GRP-treated groups were lower when compared to the control group. To elucidate the hypoglycemic mechanism(s) of the ginseng radices, glucose absorption from the small intestine, hepatic hexokinase and glucose-6-phosphatase activities, in addition to PPAR-gamma expression in adipose tissue were examined. The results strongly suggest that GRA can improve hyperglycemia in KKAy mice, possibly by blocking intestinal glucose absorption and inhibiting hepatic glucose-6-phosphatase, and GRP through the upregulation of adipocytic PPAR-y protein expression as well as inhibiting intestinal glucose absorption. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/11440080/Comparisons_between_white_ginseng_radix_and_rootlet_for_antidiabetic_activity_and_mechanism_in_KKAy_mice_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11440080.ui DB - PRIME DP - Unbound Medicine ER -