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Low serum magnesium levels and foot ulcers in subjects with type 2 diabetes.

Abstract

BACKGROUND

Hypomagnesemia is associated with the development of neuropathy and abnormal platelet activity, both of which are risk factors for the progression of ulcers of the feet. Thus, the aim of this study was to determine the relationship between low serum magnesium and foot ulcer in subjects with type 2 diabetes.

METHODS

Thirty-three out-patients with type 2 diabetes and foot ulcers (16 women and 17 men) were compared with a control group of 66 out-patients with type 2 diabetes without foot ulcers (35 women and 31 men), matched by age, diabetes duration, HbA1c, and glycemia. Patients with foot ulcers were included in the study only if a foot ulceration onset not exceeding 2 months was established. Patients diagnosed with reduced renal function, a history of alcohol intake, or as having received magnesium supplementation or diuretics were not included. Serum magnesium was measured by colorimetric method. The relationship between serum magnesium and foot ulcers was assessed by logistic regression.

RESULTS

Hypomagnesemia was identified in 31 (93.9%) subjects with foot ulcers, and 49 (73.1%) control subjects, p = 0.02. Subjects with foot ulceration had lower serum magnesium levels (1.48 +/- 0.33) than those in the control group (1.68 +/- 0.32), p <0.001. Logistic regression analysis showed a significant relationship between low serum magnesium levels and foot ulcers (odds ratio [OR] 2.9, CI 95% 1.7-6.8; p = 0.01).

CONCLUSIONS

Serum magnesium depletion is present and shows a strong relationship with foot ulcers in subjects with type 2 diabetes and foot ulcers, a relationship not previously reported.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Unidad de Investigación Médica en Epidemiología Clínica, Hospital General, Instituto Mexicano del Seguro Social (IMSS), Durango, Mexico. rodriguez_moran@hotmail.com

    Source

    MeSH

    Aged
    Cross-Sectional Studies
    Diabetes Mellitus, Type 2
    Diabetic Foot
    Female
    Humans
    Magnesium
    Magnesium Deficiency
    Male
    Mexico
    Middle Aged
    Regression Analysis

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    11440788

    Citation

    Rodríguez-Morán, M, and F Guerrero-Romero. "Low Serum Magnesium Levels and Foot Ulcers in Subjects With Type 2 Diabetes." Archives of Medical Research, vol. 32, no. 4, 2001, pp. 300-3.
    Rodríguez-Morán M, Guerrero-Romero F. Low serum magnesium levels and foot ulcers in subjects with type 2 diabetes. Arch Med Res. 2001;32(4):300-3.
    Rodríguez-Morán, M., & Guerrero-Romero, F. (2001). Low serum magnesium levels and foot ulcers in subjects with type 2 diabetes. Archives of Medical Research, 32(4), pp. 300-3.
    Rodríguez-Morán M, Guerrero-Romero F. Low Serum Magnesium Levels and Foot Ulcers in Subjects With Type 2 Diabetes. Arch Med Res. 2001;32(4):300-3. PubMed PMID: 11440788.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Low serum magnesium levels and foot ulcers in subjects with type 2 diabetes. AU - Rodríguez-Morán,M, AU - Guerrero-Romero,F, PY - 2001/7/7/pubmed PY - 2001/8/31/medline PY - 2001/7/7/entrez SP - 300 EP - 3 JF - Archives of medical research JO - Arch. Med. Res. VL - 32 IS - 4 N2 - BACKGROUND: Hypomagnesemia is associated with the development of neuropathy and abnormal platelet activity, both of which are risk factors for the progression of ulcers of the feet. Thus, the aim of this study was to determine the relationship between low serum magnesium and foot ulcer in subjects with type 2 diabetes. METHODS: Thirty-three out-patients with type 2 diabetes and foot ulcers (16 women and 17 men) were compared with a control group of 66 out-patients with type 2 diabetes without foot ulcers (35 women and 31 men), matched by age, diabetes duration, HbA1c, and glycemia. Patients with foot ulcers were included in the study only if a foot ulceration onset not exceeding 2 months was established. Patients diagnosed with reduced renal function, a history of alcohol intake, or as having received magnesium supplementation or diuretics were not included. Serum magnesium was measured by colorimetric method. The relationship between serum magnesium and foot ulcers was assessed by logistic regression. RESULTS: Hypomagnesemia was identified in 31 (93.9%) subjects with foot ulcers, and 49 (73.1%) control subjects, p = 0.02. Subjects with foot ulceration had lower serum magnesium levels (1.48 +/- 0.33) than those in the control group (1.68 +/- 0.32), p <0.001. Logistic regression analysis showed a significant relationship between low serum magnesium levels and foot ulcers (odds ratio [OR] 2.9, CI 95% 1.7-6.8; p = 0.01). CONCLUSIONS: Serum magnesium depletion is present and shows a strong relationship with foot ulcers in subjects with type 2 diabetes and foot ulcers, a relationship not previously reported. SN - 0188-4409 UR - https://www.unboundmedicine.com/medline/citation/11440788/Low_serum_magnesium_levels_and_foot_ulcers_in_subjects_with_type_2_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0188-4409(01)00298-3 DB - PRIME DP - Unbound Medicine ER -