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Inverse associations between plasma lycopene and other carotenoids and prostate cancer.

Abstract

Although dietary intake of tomatoes and tomato products containing lycopene has been reported to reduce the risk of prostate cancer, few studies have been done on the relationship between plasma lycopene and other carotenoids and prostate cancer. This case-control study was conducted to investigate the effects of plasma lycopene, other carotenoids, and retinol, as well as alpha- and gamma-tocopherols on the risk of prostate cancer. The study included 65 patients with prostate cancer and 132 cancer-free controls; all of them were interviewed using a standard epidemiological questionnaire at the Memorial Sloan-Kettering Cancer Center from 1993 to 1997. Plasma levels of carotenoids, retinol, and tocopherols were measured by high performance liquid chromatography. An unconditional logistic regression model was used in bivariate and multivariate analyses using Statistical Analysis System (SAS). After adjusting for age, race, years of education, daily caloric intake, pack-years of smoking, alcohol consumption, and family history of prostate cancer, significantly inverse associations with prostate cancer were observed with plasma concentrations of the following carotenoids: lycopene [odds ratio (OR), 0.17; 95% confidence interval (CI), 0.04-0.78; P for trend, 0.0052] and zeaxanthin (OR, 0.22; 95% CI, 0.06-0.83; P for trend, 0.0028) when comparing highest with lowest quartiles. Borderline associations were found for lutein (OR, 0.30; 95% CI, 0.09-1.03; P for trend, 0.0064) and beta-cryptoxanthin (OR, 0.31; 95% CI, 0.08-1.24; P for trend, 0.0666). No obvious associations were found for alpha- and beta-carotenes, retinol, and alpha- and gamma-tocopherols. Our study confirmed the inverse associations between lycopene, other carotenoids such as zeaxanthin, lutein, and beta-cryptoxanthin, and prostate cancer. This study provides justification for further research on the associations between lycopene and other antioxidants and the risk of prostate cancer.

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  • Authors+Show Affiliations

    ,

    Center for Human Nutrition, University of California at Los Angeles School of Medicine, Los Angeles, CA 90095, USA. qlu@mednet.ucla.edu

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    Source

    MeSH

    Adult
    Carotenoids
    Case-Control Studies
    Cryptoxanthins
    Humans
    Lutein
    Lycopene
    Male
    Middle Aged
    Odds Ratio
    Prostatic Neoplasms
    Risk Factors
    Xanthophylls
    Zeaxanthins
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11440960

    Citation

    Lu, Q Y., et al. "Inverse Associations Between Plasma Lycopene and Other Carotenoids and Prostate Cancer." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 10, no. 7, 2001, pp. 749-56.
    Lu QY, Hung JC, Heber D, et al. Inverse associations between plasma lycopene and other carotenoids and prostate cancer. Cancer Epidemiol Biomarkers Prev. 2001;10(7):749-56.
    Lu, Q. Y., Hung, J. C., Heber, D., Go, V. L., Reuter, V. E., Cordon-Cardo, C., ... Zhang, Z. F. (2001). Inverse associations between plasma lycopene and other carotenoids and prostate cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 10(7), pp. 749-56.
    Lu QY, et al. Inverse Associations Between Plasma Lycopene and Other Carotenoids and Prostate Cancer. Cancer Epidemiol Biomarkers Prev. 2001;10(7):749-56. PubMed PMID: 11440960.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Inverse associations between plasma lycopene and other carotenoids and prostate cancer. AU - Lu,Q Y, AU - Hung,J C, AU - Heber,D, AU - Go,V L, AU - Reuter,V E, AU - Cordon-Cardo,C, AU - Scher,H I, AU - Marshall,J R, AU - Zhang,Z F, PY - 2001/7/7/pubmed PY - 2001/8/24/medline PY - 2001/7/7/entrez SP - 749 EP - 56 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 10 IS - 7 N2 - Although dietary intake of tomatoes and tomato products containing lycopene has been reported to reduce the risk of prostate cancer, few studies have been done on the relationship between plasma lycopene and other carotenoids and prostate cancer. This case-control study was conducted to investigate the effects of plasma lycopene, other carotenoids, and retinol, as well as alpha- and gamma-tocopherols on the risk of prostate cancer. The study included 65 patients with prostate cancer and 132 cancer-free controls; all of them were interviewed using a standard epidemiological questionnaire at the Memorial Sloan-Kettering Cancer Center from 1993 to 1997. Plasma levels of carotenoids, retinol, and tocopherols were measured by high performance liquid chromatography. An unconditional logistic regression model was used in bivariate and multivariate analyses using Statistical Analysis System (SAS). After adjusting for age, race, years of education, daily caloric intake, pack-years of smoking, alcohol consumption, and family history of prostate cancer, significantly inverse associations with prostate cancer were observed with plasma concentrations of the following carotenoids: lycopene [odds ratio (OR), 0.17; 95% confidence interval (CI), 0.04-0.78; P for trend, 0.0052] and zeaxanthin (OR, 0.22; 95% CI, 0.06-0.83; P for trend, 0.0028) when comparing highest with lowest quartiles. Borderline associations were found for lutein (OR, 0.30; 95% CI, 0.09-1.03; P for trend, 0.0064) and beta-cryptoxanthin (OR, 0.31; 95% CI, 0.08-1.24; P for trend, 0.0666). No obvious associations were found for alpha- and beta-carotenes, retinol, and alpha- and gamma-tocopherols. Our study confirmed the inverse associations between lycopene, other carotenoids such as zeaxanthin, lutein, and beta-cryptoxanthin, and prostate cancer. This study provides justification for further research on the associations between lycopene and other antioxidants and the risk of prostate cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/11440960/Inverse_associations_between_plasma_lycopene_and_other_carotenoids_and_prostate_cancer_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=11440960 DB - PRIME DP - Unbound Medicine ER -