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Olanzapine versus haloperidol in the treatment of patients with chronic schizophrenia: results of the Japan multicenter, double-blind olanzapine trial.
Psychiatry Clin Neurosci. 2001 Aug; 55(4):403-14.PC

Abstract

This randomized double-blind trial was conducted to test the efficacy and safety of olanzapine in Japanese patients with schizophrenia. Importantly, this study also represents the first large clinical trial of olanzapine conducted in an Asian population. Patients (n = 182) were randomly assigned to treatment with olanzapine or haloperidol over a period of 8 weeks. The primary analyses included: (i) a test of non-inferiority of olanzapine compared with haloperidol in efficacy using the Final Global Improvement Rating (FGIR); and (ii) comparison between the treatment groups in extrapyramidal symptom severity using the Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS). Olanzapine was comparable to haloperidol in efficacy in treating positive symptoms and significantly superior in treating negative symptoms. Extrapyramidal symptom severity was significantly improved for olanzapine-treated patients versus haloperidol-treated patients. Olanzapine was shown to be more effective and better tolerated than haloperidol in the treatment of Japanese patients suffering from chronic schizophrenia.

Authors+Show Affiliations

Department of Psychiatry, Kitasato University School of Medicine, 2-1-1 Asamizodai, Sagami-hara 228-8520, Japan. jun-i@ma-2.justnet.ne.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

11442893

Citation

Ishigooka, J, et al. "Olanzapine Versus Haloperidol in the Treatment of Patients With Chronic Schizophrenia: Results of the Japan Multicenter, Double-blind Olanzapine Trial." Psychiatry and Clinical Neurosciences, vol. 55, no. 4, 2001, pp. 403-14.
Ishigooka J, Inada T, Miura S. Olanzapine versus haloperidol in the treatment of patients with chronic schizophrenia: results of the Japan multicenter, double-blind olanzapine trial. Psychiatry Clin Neurosci. 2001;55(4):403-14.
Ishigooka, J., Inada, T., & Miura, S. (2001). Olanzapine versus haloperidol in the treatment of patients with chronic schizophrenia: results of the Japan multicenter, double-blind olanzapine trial. Psychiatry and Clinical Neurosciences, 55(4), 403-14.
Ishigooka J, Inada T, Miura S. Olanzapine Versus Haloperidol in the Treatment of Patients With Chronic Schizophrenia: Results of the Japan Multicenter, Double-blind Olanzapine Trial. Psychiatry Clin Neurosci. 2001;55(4):403-14. PubMed PMID: 11442893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Olanzapine versus haloperidol in the treatment of patients with chronic schizophrenia: results of the Japan multicenter, double-blind olanzapine trial. AU - Ishigooka,J, AU - Inada,T, AU - Miura,S, PY - 2001/7/10/pubmed PY - 2001/10/5/medline PY - 2001/7/10/entrez SP - 403 EP - 14 JF - Psychiatry and clinical neurosciences JO - Psychiatry Clin Neurosci VL - 55 IS - 4 N2 - This randomized double-blind trial was conducted to test the efficacy and safety of olanzapine in Japanese patients with schizophrenia. Importantly, this study also represents the first large clinical trial of olanzapine conducted in an Asian population. Patients (n = 182) were randomly assigned to treatment with olanzapine or haloperidol over a period of 8 weeks. The primary analyses included: (i) a test of non-inferiority of olanzapine compared with haloperidol in efficacy using the Final Global Improvement Rating (FGIR); and (ii) comparison between the treatment groups in extrapyramidal symptom severity using the Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS). Olanzapine was comparable to haloperidol in efficacy in treating positive symptoms and significantly superior in treating negative symptoms. Extrapyramidal symptom severity was significantly improved for olanzapine-treated patients versus haloperidol-treated patients. Olanzapine was shown to be more effective and better tolerated than haloperidol in the treatment of Japanese patients suffering from chronic schizophrenia. SN - 1323-1316 UR - https://www.unboundmedicine.com/medline/citation/11442893/Olanzapine_versus_haloperidol_in_the_treatment_of_patients_with_chronic_schizophrenia:_results_of_the_Japan_multicenter_double_blind_olanzapine_trial_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1323-1316&date=2001&volume=55&issue=4&spage=403 DB - PRIME DP - Unbound Medicine ER -