Tags

Type your tag names separated by a space and hit enter

Local interferon-gamma levels during respiratory syncytial virus lower respiratory tract infection are associated with disease severity.
J Infect Dis. 2001 Aug 01; 184(3):355-8.JI

Abstract

To investigate the role of cell-mediated immunity during respiratory syncytial virus (RSV) infection, interferon (IFN)-gamma and interleukin (IL)-10 levels in nasopharyngeal secretions were measured in infants with lower respiratory tract infection (LRTI) caused by RSV. A novel technique was used to measure in vivo cytokine levels in nasopharyngeal aspirates (NPAs). Cytokine levels in the NPAs of 17 mechanically ventilated infants and 43 nonventilated hospitalized infants were compared. As expected, mechanically ventilated infants were significantly younger than nonventilated infants (7 vs. 14 weeks). IFN-gamma levels were above the limit of detection in the NPAs of 3 (18%) mechanically ventilated infants and in the NPAs of 26 (60%) nonventilated infants. IL-10 levels in the NPAs of mechanically ventilated and nonventilated infants were comparable. It is hypothesized that maturation-related mechanisms have a key role in the development of RSV LRTI that results in mechanical ventilation.

Authors+Show Affiliations

Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11443563

Citation

Bont, L, et al. "Local Interferon-gamma Levels During Respiratory Syncytial Virus Lower Respiratory Tract Infection Are Associated With Disease Severity." The Journal of Infectious Diseases, vol. 184, no. 3, 2001, pp. 355-8.
Bont L, Heijnen CJ, Kavelaars A, et al. Local interferon-gamma levels during respiratory syncytial virus lower respiratory tract infection are associated with disease severity. J Infect Dis. 2001;184(3):355-8.
Bont, L., Heijnen, C. J., Kavelaars, A., van Aalderen, W. M., Brus, F., Draaisma, J. M., Pekelharing-Berghuis, M., van Diemen-Steenvoorde, R. A., & Kimpen, J. L. (2001). Local interferon-gamma levels during respiratory syncytial virus lower respiratory tract infection are associated with disease severity. The Journal of Infectious Diseases, 184(3), 355-8.
Bont L, et al. Local Interferon-gamma Levels During Respiratory Syncytial Virus Lower Respiratory Tract Infection Are Associated With Disease Severity. J Infect Dis. 2001 Aug 1;184(3):355-8. PubMed PMID: 11443563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Local interferon-gamma levels during respiratory syncytial virus lower respiratory tract infection are associated with disease severity. AU - Bont,L, AU - Heijnen,C J, AU - Kavelaars,A, AU - van Aalderen,W M, AU - Brus,F, AU - Draaisma,J M, AU - Pekelharing-Berghuis,M, AU - van Diemen-Steenvoorde,R A, AU - Kimpen,J L, Y1 - 2001/06/26/ PY - 2001/01/04/received PY - 2001/03/21/revised PY - 2001/7/10/pubmed PY - 2001/8/24/medline PY - 2001/7/10/entrez SP - 355 EP - 8 JF - The Journal of infectious diseases JO - J Infect Dis VL - 184 IS - 3 N2 - To investigate the role of cell-mediated immunity during respiratory syncytial virus (RSV) infection, interferon (IFN)-gamma and interleukin (IL)-10 levels in nasopharyngeal secretions were measured in infants with lower respiratory tract infection (LRTI) caused by RSV. A novel technique was used to measure in vivo cytokine levels in nasopharyngeal aspirates (NPAs). Cytokine levels in the NPAs of 17 mechanically ventilated infants and 43 nonventilated hospitalized infants were compared. As expected, mechanically ventilated infants were significantly younger than nonventilated infants (7 vs. 14 weeks). IFN-gamma levels were above the limit of detection in the NPAs of 3 (18%) mechanically ventilated infants and in the NPAs of 26 (60%) nonventilated infants. IL-10 levels in the NPAs of mechanically ventilated and nonventilated infants were comparable. It is hypothesized that maturation-related mechanisms have a key role in the development of RSV LRTI that results in mechanical ventilation. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/11443563/Local_interferon_gamma_levels_during_respiratory_syncytial_virus_lower_respiratory_tract_infection_are_associated_with_disease_severity_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/322035 DB - PRIME DP - Unbound Medicine ER -