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[Semax and selank inhibit the enkephalin-degrading enzymes from human serum]].
Bioorg Khim. 2001 May-Jun; 27(3):180-3.BK

Abstract

A dose-dependent effect of synthetic heptapeptides Semax (Met-Glu-His-Phe-Pro-Gly-Pro) and Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on the enkephalin-degrading enzymes of human serum was demonstrated. The inhibitory effects of Semax (IC50 10 microM) and Selank (IC50 20 microM) are more pronounced than those of puromycin (IC50 10 mM), bacitracin, and some other inhibitors of peptidases. Beside the heptapeptides, their pentapeptide fragments also possessed an inhibitory effect; tri-, tetra-, and hexapeptide fragments did not display such an effect. As the above enzymes take part in degradation of not only enkephalins but also other regulatory peptides, it can be assumed that one of the mechanisms of biological activity of Semax and Selank is related to this inhibitory activity of theirs.

Authors+Show Affiliations

Kost NV
National Research Center for Mental Health, Russian Academy of Medical Sciences, Zagorodnoe shosse 2/2, Moscow, 113152 Russia. kost@rcmh.msk.ru
Sokolov OIu
No affiliation info available
Gabaeva MV
No affiliation info available
Grivennikov IA
No affiliation info available
Andreeva LA
No affiliation info available
Miasoedov NF
No affiliation info available
Zozulia AA
No affiliation info available

MeSH

Adrenocorticotropic HormoneDose-Response Relationship, DrugEnzyme InhibitorsHumansNeprilysinOligopeptidesPeptide Fragments

Pub Type(s)

Journal Article

Language

rus

PubMed ID

11443939

Citation

Kost, N V., et al. "[Semax and Selank Inhibit the Enkephalin-degrading Enzymes From Human Serum]]." Bioorganicheskaia Khimiia, vol. 27, no. 3, 2001, pp. 180-3.
Kost NV, Sokolov OIu, Gabaeva MV, et al. [Semax and selank inhibit the enkephalin-degrading enzymes from human serum]]. Bioorg Khim. 2001;27(3):180-3.
Kost, N. V., Sokolov, O. I. u., Gabaeva, M. V., Grivennikov, I. A., Andreeva, L. A., Miasoedov, N. F., & Zozulia, A. A. (2001). [Semax and selank inhibit the enkephalin-degrading enzymes from human serum]]. Bioorganicheskaia Khimiia, 27(3), 180-3.
Kost NV, et al. [Semax and Selank Inhibit the Enkephalin-degrading Enzymes From Human Serum]]. Bioorg Khim. 2001 May-Jun;27(3):180-3. PubMed PMID: 11443939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Semax and selank inhibit the enkephalin-degrading enzymes from human serum]]. AU - Kost,N V, AU - Sokolov,O Iu, AU - Gabaeva,M V, AU - Grivennikov,I A, AU - Andreeva,L A, AU - Miasoedov,N F, AU - Zozulia,A A, PY - 2001/7/11/pubmed PY - 2002/1/5/medline PY - 2001/7/11/entrez SP - 180 EP - 3 JF - Bioorganicheskaia khimiia JO - Bioorg Khim VL - 27 IS - 3 N2 - A dose-dependent effect of synthetic heptapeptides Semax (Met-Glu-His-Phe-Pro-Gly-Pro) and Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on the enkephalin-degrading enzymes of human serum was demonstrated. The inhibitory effects of Semax (IC50 10 microM) and Selank (IC50 20 microM) are more pronounced than those of puromycin (IC50 10 mM), bacitracin, and some other inhibitors of peptidases. Beside the heptapeptides, their pentapeptide fragments also possessed an inhibitory effect; tri-, tetra-, and hexapeptide fragments did not display such an effect. As the above enzymes take part in degradation of not only enkephalins but also other regulatory peptides, it can be assumed that one of the mechanisms of biological activity of Semax and Selank is related to this inhibitory activity of theirs. SN - 0132-3423 UR - https://www.unboundmedicine.com/medline/citation/11443939/[Semax_and_selank_inhibit_the_enkephalin_degrading_enzymes_from_human_serum]]_ L2 - https://antibodies.cancer.gov/detail/CPTC-HLA-B-1 DB - PRIME DP - Unbound Medicine ER -