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Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus.
J Am Coll Nutr. 2001 Jun; 20(3):212-8.JA

Abstract

OBJECTIVE

To determine the effects of combined zinc (Zn) and chromium (Cr) supplementation on oxidative stress and glucose homeostasis of people with type 2 diabetes.

DESIGN

Tunisian adult subjects with HbA1C > 7.5% were supplemented for 6 months with 30 mg/d of Zn as Zn gluconate or 400 microg/d of Cr as Cr pidolate or combined Zn/Cr supplementation or placebo. The effects of supplementation on plasma zinc (Zn), copper (Cu), selenium (Se), urinary Zn, Cr, plasma thiobarbituric acid reactive substances (TBARS), Cu-Zn superoxide dismutase (SOD) and Se glutathione peroxidase (GPx) in red blood cells, blood lipids and lipoproteins, HbA1C and fasting glucose were measured at the beginning of the study and after six months.

RESULTS

At the beginning of the study, more than 30% of the subjects may have been Zn deficient with plasma Zn values less than 10.7 mircomol/L, whereas levels of plasma Cu, Se and antioxidant RBC enzyme activities were in the normal ranges. Following supplementation, there were significant decreases of plasma TBARS in the Cr (13.6%), Zn (13.6%) and Zn/Cr (18.2%) groups with no significant changes in the placebo group. The value for the TBARS of the control healthy Tunisian subjects was 2.08 +/- 0.04 micromol/L and that of the Tunisian subjects with diabetes was 3.32 +/- 0.05 micromol/L. This difference of 1.24 micromol/L between the control group and the subjects with diabetes was reduced from 36% to 50% in the three supplemented groups. Supplementation did not modify significantly HbAIC nor glucose homeostasis. No adverse effects of Zn supplementation were observed on Cu status. HDL cholesterol nor interactions in Zn or Cr.

CONCLUSIONS

These data suggest the potential beneficial antioxidant effects of the individual and combined supplementation of Zn and Cr in people with type 2 DM. These results are particularly important in light of the deleterious consequences of oxidative stress in people with diabetes.

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Publisher Full Text

Authors+Show Affiliations

Anderson RA
Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, USDA, ARS, MD 20705, USA. anderson@307.bhnrc.usda.gov
Roussel AM
No affiliation info available
Zouari N
No affiliation info available
Mahjoub S
No affiliation info available
Matheau JM
No affiliation info available
Kerkeni A
No affiliation info available

MeSH

AdultAntioxidantsBlood GlucoseChromiumCopperDiabetes Mellitus, Type 2Dietary SupplementsDouble-Blind MethodFemaleGlutathione PeroxidaseGlycated Hemoglobin AHumansMaleMiddle AgedOxidation-ReductionOxidative StressSeleniumSuperoxide DismutaseThiobarbituric Acid Reactive SubstancesTunisiaZinc

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11444416

Citation

Anderson, R A., et al. "Potential Antioxidant Effects of Zinc and Chromium Supplementation in People With Type 2 Diabetes Mellitus." Journal of the American College of Nutrition, vol. 20, no. 3, 2001, pp. 212-8.
Anderson RA, Roussel AM, Zouari N, et al. Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus. J Am Coll Nutr. 2001;20(3):212-8.
Anderson, R. A., Roussel, A. M., Zouari, N., Mahjoub, S., Matheau, J. M., & Kerkeni, A. (2001). Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus. Journal of the American College of Nutrition, 20(3), 212-8.
Anderson RA, et al. Potential Antioxidant Effects of Zinc and Chromium Supplementation in People With Type 2 Diabetes Mellitus. J Am Coll Nutr. 2001;20(3):212-8. PubMed PMID: 11444416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus. AU - Anderson,R A, AU - Roussel,A M, AU - Zouari,N, AU - Mahjoub,S, AU - Matheau,J M, AU - Kerkeni,A, PY - 2001/7/11/pubmed PY - 2002/1/5/medline PY - 2001/7/11/entrez SP - 212 EP - 8 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 20 IS - 3 N2 - OBJECTIVE: To determine the effects of combined zinc (Zn) and chromium (Cr) supplementation on oxidative stress and glucose homeostasis of people with type 2 diabetes. DESIGN: Tunisian adult subjects with HbA1C > 7.5% were supplemented for 6 months with 30 mg/d of Zn as Zn gluconate or 400 microg/d of Cr as Cr pidolate or combined Zn/Cr supplementation or placebo. The effects of supplementation on plasma zinc (Zn), copper (Cu), selenium (Se), urinary Zn, Cr, plasma thiobarbituric acid reactive substances (TBARS), Cu-Zn superoxide dismutase (SOD) and Se glutathione peroxidase (GPx) in red blood cells, blood lipids and lipoproteins, HbA1C and fasting glucose were measured at the beginning of the study and after six months. RESULTS: At the beginning of the study, more than 30% of the subjects may have been Zn deficient with plasma Zn values less than 10.7 mircomol/L, whereas levels of plasma Cu, Se and antioxidant RBC enzyme activities were in the normal ranges. Following supplementation, there were significant decreases of plasma TBARS in the Cr (13.6%), Zn (13.6%) and Zn/Cr (18.2%) groups with no significant changes in the placebo group. The value for the TBARS of the control healthy Tunisian subjects was 2.08 +/- 0.04 micromol/L and that of the Tunisian subjects with diabetes was 3.32 +/- 0.05 micromol/L. This difference of 1.24 micromol/L between the control group and the subjects with diabetes was reduced from 36% to 50% in the three supplemented groups. Supplementation did not modify significantly HbAIC nor glucose homeostasis. No adverse effects of Zn supplementation were observed on Cu status. HDL cholesterol nor interactions in Zn or Cr. CONCLUSIONS: These data suggest the potential beneficial antioxidant effects of the individual and combined supplementation of Zn and Cr in people with type 2 DM. These results are particularly important in light of the deleterious consequences of oxidative stress in people with diabetes. SN - 0731-5724 UR - https://www.unboundmedicine.com/medline/citation/11444416/Potential_antioxidant_effects_of_zinc_and_chromium_supplementation_in_people_with_type_2_diabetes_mellitus_ L2 - https://www.tandfonline.com/doi/full/10.1080/07315724.2001.10719034 DB - PRIME DP - Unbound Medicine ER -