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Helicobacter pylori and iron deficiency anaemia in children.
Scand J Gastroenterol. 2001 Jul; 36(7):701-5.SJ

Abstract

BACKGROUND

Both iron deficiency anaemia and Helicobacter pylori infection are rare in developed countries. A possible connection has been suggested between these two diseases and our aim was to define the clinical picture and to study the effect of bacterial eradication in H. pylori colonized children with severe anaemia.

METHODS

Eight children with iron deficiency anaemia refractory to iron supplementation were examined with gastroscopy because of suspicion of H. pylori infection. Anaemia was treated with oral ferrous sulphate. Two patients needed blood transfusions. Eradication therapy was given either with combination of colloidal bismuth subcitrate and metronidazole or with omeprazole, clarithromycin and amoxycillin. Eradication was confirmed by urea breath test 4 weeks post-treatment.

RESULTS

H. pylori infection was confirmed histologically and microbiologically in all children, who also presented with chronic, active gastritis. Bacteria were successfully eradicated in 7/8 patients. Correction of haemoglobin values was observed post-treatment, iron stores still being deficient at control in 4/8 children.

CONCLUSIONS

Our results suggest that H. pylori might have a role in causing iron deficiency anaemia in school-age children. Screening for H. pylori should be extended to cover those patients with other clinical manifestations than symptoms from gastrointestinal tract.

Authors+Show Affiliations

Dept. of Pediatrics, Tampere University Hospital, Finland. merja.ashorn@uta.fiNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11444468

Citation

Ashorn, M, et al. "Helicobacter Pylori and Iron Deficiency Anaemia in Children." Scandinavian Journal of Gastroenterology, vol. 36, no. 7, 2001, pp. 701-5.
Ashorn M, Ruuska T, Mäkipernaa A. Helicobacter pylori and iron deficiency anaemia in children. Scand J Gastroenterol. 2001;36(7):701-5.
Ashorn, M., Ruuska, T., & Mäkipernaa, A. (2001). Helicobacter pylori and iron deficiency anaemia in children. Scandinavian Journal of Gastroenterology, 36(7), 701-5.
Ashorn M, Ruuska T, Mäkipernaa A. Helicobacter Pylori and Iron Deficiency Anaemia in Children. Scand J Gastroenterol. 2001;36(7):701-5. PubMed PMID: 11444468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori and iron deficiency anaemia in children. AU - Ashorn,M, AU - Ruuska,T, AU - Mäkipernaa,A, PY - 2001/7/11/pubmed PY - 2002/1/5/medline PY - 2001/7/11/entrez SP - 701 EP - 5 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 36 IS - 7 N2 - BACKGROUND: Both iron deficiency anaemia and Helicobacter pylori infection are rare in developed countries. A possible connection has been suggested between these two diseases and our aim was to define the clinical picture and to study the effect of bacterial eradication in H. pylori colonized children with severe anaemia. METHODS: Eight children with iron deficiency anaemia refractory to iron supplementation were examined with gastroscopy because of suspicion of H. pylori infection. Anaemia was treated with oral ferrous sulphate. Two patients needed blood transfusions. Eradication therapy was given either with combination of colloidal bismuth subcitrate and metronidazole or with omeprazole, clarithromycin and amoxycillin. Eradication was confirmed by urea breath test 4 weeks post-treatment. RESULTS: H. pylori infection was confirmed histologically and microbiologically in all children, who also presented with chronic, active gastritis. Bacteria were successfully eradicated in 7/8 patients. Correction of haemoglobin values was observed post-treatment, iron stores still being deficient at control in 4/8 children. CONCLUSIONS: Our results suggest that H. pylori might have a role in causing iron deficiency anaemia in school-age children. Screening for H. pylori should be extended to cover those patients with other clinical manifestations than symptoms from gastrointestinal tract. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/11444468/Helicobacter_pylori_and_iron_deficiency_anaemia_in_children_ L2 - https://www.tandfonline.com/doi/full/10.1080/003655201300191950 DB - PRIME DP - Unbound Medicine ER -