Tags

Type your tag names separated by a space and hit enter

Experimenting on the past: the enigma of von Economo's encephalitis lethargica.
J Neuropathol Exp Neurol. 2001 Jul; 60(7):663-70.JN

Abstract

Encephalitis lethargica (EL) was a complex and mysterious disease that appeared around the same time as the great influenza pandemic of 1918. The contemporaneous relationship of the 2 diseases led to speculation that they were causally related. Contemporary and subsequent observers conjectured that the influenza virus, directly responsible for the deaths of more than 20 million people, might also have been the cause of EL. A review of the extensive literature by observers of the EL epidemic suggests that most contemporary clinicians, epidemiologists, and pathologists rejected the theory that the 1918 influenza virus was directly responsible for EL. Disappearance of the acute form of EL during the 1920s has precluded direct study of this entity. However, modern molecular biology techniques have made it possible to examine archival tissue samples from victims of the 1918 pandemic in order to detect and study the genetic structure of the killer virus. Similarly, tissue samples from EL victims can now be examined for evidence of infection by the 1918 influenza virus.

Authors+Show Affiliations

Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Washington, DC, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Biography
Historical Article
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

11444794

Citation

Reid, A H., et al. "Experimenting On the Past: the Enigma of Von Economo's Encephalitis Lethargica." Journal of Neuropathology and Experimental Neurology, vol. 60, no. 7, 2001, pp. 663-70.
Reid AH, McCall S, Henry JM, et al. Experimenting on the past: the enigma of von Economo's encephalitis lethargica. J Neuropathol Exp Neurol. 2001;60(7):663-70.
Reid, A. H., McCall, S., Henry, J. M., & Taubenberger, J. K. (2001). Experimenting on the past: the enigma of von Economo's encephalitis lethargica. Journal of Neuropathology and Experimental Neurology, 60(7), 663-70.
Reid AH, et al. Experimenting On the Past: the Enigma of Von Economo's Encephalitis Lethargica. J Neuropathol Exp Neurol. 2001;60(7):663-70. PubMed PMID: 11444794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experimenting on the past: the enigma of von Economo's encephalitis lethargica. AU - Reid,A H, AU - McCall,S, AU - Henry,J M, AU - Taubenberger,J K, PY - 2001/7/11/pubmed PY - 2001/7/20/medline PY - 2001/7/11/entrez SP - 663 EP - 70 JF - Journal of neuropathology and experimental neurology JO - J Neuropathol Exp Neurol VL - 60 IS - 7 N2 - Encephalitis lethargica (EL) was a complex and mysterious disease that appeared around the same time as the great influenza pandemic of 1918. The contemporaneous relationship of the 2 diseases led to speculation that they were causally related. Contemporary and subsequent observers conjectured that the influenza virus, directly responsible for the deaths of more than 20 million people, might also have been the cause of EL. A review of the extensive literature by observers of the EL epidemic suggests that most contemporary clinicians, epidemiologists, and pathologists rejected the theory that the 1918 influenza virus was directly responsible for EL. Disappearance of the acute form of EL during the 1920s has precluded direct study of this entity. However, modern molecular biology techniques have made it possible to examine archival tissue samples from victims of the 1918 pandemic in order to detect and study the genetic structure of the killer virus. Similarly, tissue samples from EL victims can now be examined for evidence of infection by the 1918 influenza virus. SN - 0022-3069 UR - https://www.unboundmedicine.com/medline/citation/11444794/Experimenting_on_the_past:_the_enigma_of_von_Economo's_encephalitis_lethargica_ L2 - https://academic.oup.com/jnen/article-lookup/doi/10.1093/jnen/60.7.663 DB - PRIME DP - Unbound Medicine ER -